Research Assistant/Associate (Fixed Term)
We are pleased to advertise a post for a Research Assistant/Associate to study
the composition and role of tricellular adherens junctions in epithelial
morphogenesis in Dr Bénédicte Sanson's group.
We have discovered the first known resident component of tricellular adherens
junctions (tAJs) in the fruit fly Drosophila, the transmembrane adhesion
molecule Sidekick (Sdk) 1,2. Sidekick, and thus tAJs, have been shown to
be important in various aspects of epithelial morphogenesis in several tissues
in Drosophila. We propose here to elucidate how Sidekick localises at tAJs and
to understand better Sidekick's role in facilitating cell rearrangements
during the extension of the main body axis in fly embryos. Approaches for the
project will include molecular dissection of Sdk, optogenetics and super-
resolution microscopy, the latter in collaboration with Prof. Daniel St
Johnston (Gurdon Institute) and the Cambridge Advanced Imaging Centre. There
will also be an opportunity to collaborate with Dr Clare Buckley (PDN) to
address the conservation of this epithelial role of Sdk in vertebrates, in the
The approaches developed for this project will complement and synergise with
existing approaches in the lab, including Drosophila genetics, advanced live
imaging, computational analysis of cell behaviours and mathematical modelling.
We are looking to recruit either at Research Assistant or Research Associate
The post is available for an immediate start with funding for the project
available to the end of September 2023 in the first instance.
1 Finegan TM, Hervieux N, Nestor-Bergmann A, Fletcher AG, Blanchard GB,
Sanson B. (2019) The tricellular vertex-specific adhesion molecule Sidekick
facilitates polarised cell intercalation during Drosophila axis extension.
PLoS Biol. doi: 10.1371/journal.pbio.3000522. 2 Lye CM, Naylor HW, Sanson
B. (2014) Subcellular localisations of the CPTI collection of YFP-tagged
proteins in Drosophila embryos. Development. doi: 10.1242/dev.111310.
We welcome applications from individuals who wish to be considered for part-
time working or other flexible working arrangements.
We particularly welcome applications from women and /or candidates from a
Black, Asian or Minority Ethnic background for this vacancy as they are
currently under-represented at this level in our department.
Click the 'Apply' button below to register an account with our recruitment
system (if you have not already) and apply online.
The closing date for applications is midnight on 30 November 2021.
If you have any questions about this vacancy, please contact Professor
Benedicte Sanson at email@example.com.
Please quote reference PM28456 on your application and in any correspondence
about this vacancy.
The University actively supports equality, diversity and inclusion and
encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible
to live and work in the UK.
Research AsstAssoc Further Particulars
Department of Physiology, Development and Neuroscience
11 October 2021
30 November 2021