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The Paulson/Sharkey laboratories are looking for a Research Area Specialist
Associate skilled in molecular biology, biochemistry and proteomic techniques.
The overarching goals of the laboratory are to 1) understand the mechanisms
that regulate protein homeostasis in neurons and 2) to determine why deficits
in these pathways lead to protein misfolding/aggregation and neurotoxicity. We
study these pathways with the goal of developing potential treatments for
neurodegenerative diseases such as Alzheimer's Disease, amyotrophic lateral
sclerosis and frontotemporal dementia. Specifically, the successful candidate
will work alongside Dr. Paulson, Dr. Sharkey and existing lab members to
design, perform, and interpret experiments focused on the ubiquilin family of
proteins and their role in protein quality control in the cell. In addition,
they will supervise and help train both undergraduate research assistant as
well as junior technicians in the lab.
Michigan Medicine improves the health of patients, populations and communities
through excellence in education, patient care, community service, research and
technology development, and through leadership activities in Michigan,
nationally and internationally. Our mission is guided by our Strategic
Principles and has three critical components; patient care, education and
research that together enhance our contribution to society.
Why Join Michigan Medicine?
Michigan Medicine is one of the largest health care complexes in the world and
has been the site of many groundbreaking medical and technological
advancements since the opening of the U-M Medical School in 1850. Michigan
Medicine is comprised of over 30,000 employees and our vision is to attract,
inspire, and develop outstanding people in medicine, sciences, and healthcare
to become one of the world's most distinguished academic health systems. In
some way, great or small, every person here helps to advance this world-class
institution. Work at Michigan Medicine and become a victor for the greater
What Benefits can you Look Forward to?
Excellent medical, dental and vision coverage effective on your very first
2:1 Match on retirement savings
Responsibilities include but are not limited to:
Train users in equipment operation and standard techniques
Participate in periodic research discussions
Present data and plans for new experiments
Collaborate with colleagues to achieve short and long range plans
Help assemble manuscripts, chapters and research abstracts
Additional duties as assigned
Requirements include a masters degree in the biological sciences, including
molecular biology, biochemistry or a related discipline and 1-2 years of
laboratory experience which could include classroom laboratory experience or
Candidates will be expected to actively take part in collaborations.
Applicants should be reliable and able to work well within a group. Preference
will be given to applicants who seek more than 1-2 years of commitment to this
Familiarity with basic techniques in biomedical research including mammalian
and primary cell culture, DNA/RNA extraction and purification, quantitative
real-time PCR, Western blotting, and fluorescence microscopy. Experience with
mouse colony husbandry, genotyping, and tissue dissection and analysis is also
Michigan Medicine conducts background screening and pre-employment drug
testing on job candidates upon acceptance of a contingent job offer and may
use a third party administrator to conduct background screenings. Background
screenings are performed in compliance with the Fair Credit Report Act. Pre-
employment drug testing applies to all selected candidates, including new or
additional faculty and staff appointments, as well as transfers from other U-M
U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action