Repurposing Of Fda-Approved Drugs Promoting Oligodendrogenesis For Brain Injury Of The Preterm

Universities and Institutes of France

France

September 30, 2022

Description

  • Organisation/Company: INSERM U1208
  • Research Field: Biological sciences › Biology Psychological sciences › Psychology
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2) Established Researcher (R3) Leading Researcher (R4)
  • Application Deadline: 30/09/2022 00:00 - Europe/Brussels
  • Location: France › Bron
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Offer Starting Date: 01/11/2022
  • Project: Preterm-birth brain injury (PBI) is a major public health concern, with many surviving children developing cognitive and neuropsychiatric deficits. The developmental period around birth is a time of active generation of oligodendrocytes, myelination, and axonal reorganization that is strongly perturbed in many preterm-born children. Through a pharmacogenomics analysis based on the generation and expert curation of transcriptomic datasets, we identified novel small bioactive molecules fostering oligodendrogenesis by acting on transcriptional programs underlying their proliferation or maturation. In this project, we will use cutting edge histological and transcriptional approaches to 1) dissect out the mode of action of these molecules, 2) investigate their potential effects on other lineages than oligodendroglia. This project, supported by the ANR (Project NeoReGen), and involves a close collaboration with the Parras team (ICM, Paris) and Gressens team (Diderot Hospital, Paris). For more background, see Azim et al., Plos Biol 2017, Donega et al., Cell Reports 2018, Marie C et al., PNAS, 2018.

    Funding category: Financement public/privé

    ANR

    PHD title: PhD in Neurosciences

    PHD Country: France

    Offer Requirements Specific Requirements

    Candidates: We are looking for an enthusiastic and highly motivated scientist holding a M2 in neurosciences or cellular biology and willing to join a challenging research area. Experience in histology and bioinformatic analysis/scripting would be valuable. Strong communication skills, team spirit and ability to work in a multidisciplinary team are expected.

    Contact Information
  • Organisation/Company: INSERM U1208
  • Organisation Type: Public Research Institution
  • Website: https: // www. sbri.fr/
  • Country: France
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