Postdoctoral Scientist in Leukaemia Biology

University of Oxford

United Kingdom

December 6, 2021

Description

Postdoctoral Scientist in Leukaemia Biology

Radcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, John Radcliffe Hospital, Headington, Oxford Grade 7: £33,309 -£40,927 per annum

An exciting opportunity has arisen for a highly motivated and ambitious Postdoctoral Scientist to join Professor Paresh Vyas and Professor Irene Roberts at the MRC Weatherall Institute of Molecular Medicine (WIMM). You will be based in the Vyas laboratory and will work with both Professors Vyas and Roberts, as well as other research groups based at the WIMM.

The Vyas and Roberts laboratories are world-leading in the study of the biology of acute myeloid leukaemia using paediatric leukaemia as a model. We have focussed on the myeloid leukaemia in children with Downs syndrome who have a 150-fold increased incidence of leukaemia. Through a comprehensive study of the genetics, functional studies including CRISPR-based screens and targeted loss of function studies combined with single cell biology, in primary patient samples and in vivo models, the successful applicant will now dissect how multiple leukaemic mutations cooperate to perturb blood stem and progenitor cell differentiation, with the aim of understanding fundamental principles of how genetic and epigenetic change causes arises leukaemia and that will provide a platform for rational therapy.

You will hold a PhD (or near to completion: thesis submitted at time of application) in leukaemia biology, the study of haematopoiesis or transcription factor function. You will have laboratory experience in FACS analysis and sorting, CRISPR, cell culture, single cell biology, working with in vivo models and computational experience in analysis of transcriptomic and epigenetic datasets. A strong publication record in high-impact peer-reviewed journals is a prerequisite, as well as the ability to work independently and as part of a team. You will have excellent communication and organisational skills, with the ability to manage and independently drive, innovate and complete your own research and associated activities.

This post is fixed term until 10/01/2024, funded by Blood Cancer UK.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for this position is 12 noon on Monday 06 December 2021.

Contact Person : HR Administrator Vacancy ID : 154644 Contact Phone : 01865 222321 Closing Date & Time : 06-Dec-2021 12:00 Contact Email : recruitment@imm.ox.ac.uk

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