Postdoctoral Scholar

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Job #JPF08005

Radiation Oncology / School of Medicine / UC Irvine

Position overview

Salary range: Commensurate with experience

Application Window

Open date: January 12, 2023

Most recent review date: Friday, Feb 10, 2023 at 11:59pm (Pacific Time) Applications received after this date will be reviewed by the search committee if the position has not yet been filled.

Final date: Friday, Jun 30, 2023 at 11:59pm (Pacific Time) Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.

Position description

The Department of Radiation Oncology and Dr. Charles Limoli, Professor and Vice Chair of the Radiation Oncology Department at the University of California, Irvine anticipates a postdoctoral position opening available for 2-3 years funded by National Institutes of Health (NIH). Salary will be commensurate with experience. The scholar will be responsible for investigating the efficacy of radiation- and/or chemotherapy-induced tumor cell kill and normal tissue sparing in the CNS and other peripheral organ sites. Our laboratory employs cutting edge cancer therapy paradigms with a focus on ultra-high dose rate “FLASH” radiotherapy, gene silencing, transgenic, stem cell-based and pharmacological approaches to study neurobiological mechanisms and regenerative strategies to ameliorate a wide range of normal tissue toxicities, neuroinflammation and cognitive impairments.

Requirements: The successful candidate will possess an excellent track record and a high level of motivation to conduct independent experiments and work well with a team. This position will play an integral role in the execution of the overall aims of several funded NIH grants focused on the translational potential of FLASH radiotherapy, stem cell and extracellular vesicles based strategies to enhance the therapeutic index of cancer treatments in the CNS, lung and head and neck. The candidate will also be expected to be familiar with statistics and the analysis and preparation of data sets for presentations in scientific meetings and peer-reviewed publications.

Must have hands-on experience with mice or rat handling, rodent behavior and cognitive function.

Must have experience in standard molecular and cell biology techniques (i.e. cell culture, immunohistochemistry, ELISA, Western blot, RNA, DNA, etc.).

Must possess strong skills in organization, data handling and statistical analysis. Must have proficiency in English with excellent oral, written, and interpersonal communication skills.

Must have experience in supervising/training students and research staff.

Brain and/or peripheral cancer induction (orthotopic and flank cancer models), cancer imaging (BLI, CBCT, MRI).

Hands on experience with mouse and/or rat stereotaxic surgery.

Mammalian cell culturing (human or rodent stem cells, cancer cells), isolation and characterization of extracellular vesicles (exosomes).

Confocal and/or Super-Resolution microscopy, and 3D fluorescent image quantification techniques (i.e. Imaris, Auto Quant, ClearView, Neurolucida, Stereology).

Knowledge of genetic manipulation of mammalian cells and mouse brain to knockdown or overexpress genes (i.e AAV, Lentivirus, CRISPR-Cas, Cre- LoxP).

Electrophysiology and machine learning experience would be advantageous.

Send curriculum vitae with the names and addresses of three references (please do not solicit letters) to:

Charles Limoli, Professor Vice Chair of Research and Academic Affairs Department of Radiation Oncology Medical Sciences I, B-146B University of California Irvine, California 92697-2695

Please complete your application by also submitting a statement on previous and/or past contributions to diversity, equity and inclusion.

This position is dependent on extramural funds and may be subjected to the disposition/availability of such funds. The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

Qualified candidates can apply at: https: // recruit.ap.uci.edu/apply/JPF8005

Qualifications

Basic qualifications (required at time of application)

• Must possess a Ph.D. degree and laboratory experience in neuroscience, cancer biology, molecular biology, and/or biochemistry.

Application Requirements

Document requirements

Curriculum Vitae - Your most recently updated C.V.

Cover Letter (Optional)

Statement of Research

Teaching Statement - See our guidance for writing a reflective teaching statement. (Optional)

Inclusive Excellence Activities Statement - Statement addressing how past and/or potential contributions to inclusive excellence will advance UCI's Commitment to Inclusive Excellence. See our guidance for writing an inclusive excellence activities statement.

Misc / Additional (Optional)

Reference requirements

3-5 letters of reference required

Apply link: https: // recruit.ap.uci.edu/JPF08005

Campus Information

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

As a condition of employment, you will be required to comply with the University of California Policy on Vaccination Programs – With Updated Interim Amendments. All Covered Individuals under the policy must provide proof of receiving the COVID-19 Vaccine Primary Series or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, Religious Objection, and/or Deferral based on pregnancy or recent COVID-19 diagnosis and/or treatment) no later than the applicable deadline. All Covered Individuals must also provide proof of receiving the most recent CDC- recommended COVID-19 booster or properly decline such booster no later than the applicable deadline. New University of California employees should refer to Exhibit 2, Section II.C. of the SARS-CoV-2 (COVID-19) Vaccination Program Attachment for applicable deadlines. All Covered Individuals must also provide proof of being up-to-date on seasonal influenza vaccination or properly decline such vaccination no later than the applicable deadline. Please refer to the Seasonal Influenza Vaccination Program Attachment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

Job location

Irvine, CA

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