Postdoctoral Scholar – Research Associate

University of Southern California

United States

January 8, 2022


Postdoctoral Scholar – Research Associate

Apply Keck School of Medicine Los Angeles, California

The USC Roski Eye Institute, Department of Ophthalmology is seeking a Postdoctoral Scholar-Research Associate to join its team.

We seek a motivated post-doctoral fellow to join our non-viral gene delivery system in retina for photoreceptor therapeutics project. Candidates are expected to have knowledge and experience in ultrasound technology, ocular imaging, molecular biology techniques (e.g., transfection, Crispr/Cas9), and in vivo experimentation and design. The project focus is the development of microbubble (MB)-assisted sonoporation method to deliver the Crispr/Cas9 into the eye for the treatment of debilitating hereditary retinal diseases. Project involves developmental sonoporation system and Crispr/Cas9 plasmid.

Job Summary :

The post-doctoral fellow serves as a research trainee for the purpose of enhancing and developing research competencies. Participates in planning, designing and conducting highly technical and complex research projects under the direction of a supervisor. May or may not work independently. Analyzes research data and provides interpretations. Contributes to the development of research documentation for publication and/or prepares technical reports, papers and/or records.

Responsibilities and Duties

  • Investigate ultrasound guided microbubble-assisted approach to delivering Crispr/Cas9 in the eye.
  • Build and optimize sonoporation system.
  • Develop imaging modes and techniques for integration of sonoporation.
  • Design experiments, analyze data, and recommend enhancements to imaging system.
  • Design and clone Crispr/Cas9 plasmid for gene therapy of ocular diseases.
  • Work cross-functionally with biology leads to improve process efficiency and ensure a functional and safe working environment.
  • Preferred Qualifications

  • Possess a PhD or be close to the completion of a PhD or DPhil in Biomedical engineer or relevant field
  • Background and work knowledge in ultrasound transducer, device, algorithms is required.
  • Routine molecular biology techniques include cell culture, cloning, isolation and purification of genomic and plasmid DNA is required.
  • Skills in programming languages is a plus
  • Experience in in vivo experiments is a plus.
  • (Temporary, fixed-term; one year and renewable on the recommendation of the faculty mentor and at the discretion of the dean. May be renewed up to a maximum of five years.)

    Applicant Attachments (Required): Application/Resume

    Applicant Attachments (Optional): Cover Letter

    Work Location: HC4 - Estelle Doheny Eye Institute

    Percentage of Time: 100%; 37.5 hours

    Minimum Education: Ph.D. or equivalent doctorate within previous five years Minimum Experience: 0-1 year Minimum Field of Expertise: Directly related education in research specialization with advanced knowledge of equipment, procedures and analysis methods.

    REQ20106657 Posted Date: 10/07/2021 - Thru date - 2022-01-08 Apply