Postdoctoral Scholar - Department of Physics - University of California,
Berkeley Apply now to Postdoctoral Scholar - Department of Physics -
University of California, Berkeley
Physics / College of Letters & Science - Mathematical & Physical Sciences
/ UC Berkeley
Position title: Postdoctoral Scholar
Salary range: Commensurate with experience
Percent time: 100%
Anticipated start: Spring 2022
Position duration: Initial position will be for two years, with the
possibility of an extension depending upon performance and availability of
Open date: November 23rd, 2021
Next review date: Tuesday, Dec 7, 2021 at 11:59pm (Pacific Time)
Apply by this date to ensure full consideration by the committee.
Final date: Monday, Jan 31, 2022 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received
after the review date will only be considered if the position has not yet been
As part of the Holger Mueller Research Group, in the Department of Physics, at
the University of California, we seek applications for postdoctoral
researchers in the areas relevant to developing and using a laser-based phase
plate for electron microscopy. Areas of previous experience might include
experimental physics, biological electron microscopy, or innovative use of
software for data collection and analysis in the area of cryo-EM and
Depending on the background of the applicant, the job responsibilities may
include one or more of the following:
• Constructing, operating, and optimizing new laser hardware for laser-based
phase contrast, increasing usability and reliability, minimizing imaging
artifacts, or for realizing advanced imaging modalities;
• application of laser-based phase contrast and new imaging modalities that
are enabled by the laser phase plate to biological problems, using cryo
electron tomography, including identifying biological problems, preparing
samples, and running data-taking campaigns;
• finding or developing optimized strategies to process data generated with
the laser phase plate as well as developing new imaging and data analysis
strategies to obtain atomic resolution readouts of the entire proteome.
We seek highly motivated candidates with past research success and interest in
developing and applying instruments for the biological sciences. In
particular, we are looking for candidates in three areas:
● Laser physics, including infrared lasers, frequency stabilization, optical
resonators, servo loops, the physics of optomechanics, laser-electron
interactions, as well as mechanical construction of stable optical systems;
● Biological electron microscopy, including prior experience such as use of a
phase plate, biological sample preparation, single-particle cryo-EM, cryo-ET,
and FIB milling;
● Using, developing, and refining image processing as well as interactive
software to automate the data-taking process; adding scripts to these software
packages to address special requirements; writing software to allow new
Experience in more than one of these areas is welcome, but not essential.
We have recently shown that laser-based, quantum-coherent manipulation of free
elections can help overcome long-standing problems in cryogenic electron
microscopy (cryo-EM). Our Laser Phase Plate (LPP), together with advances
in direct electron detectors, will make it possible to extract all information
that is present in the electron beam at the standard quantum limit.
Funding has now arrived from the Chan-Zuckerberg Initiative for “Laser Phase
Contrast in cryo-EM for Visual Proteomics at Atomic Resolution,” to set up a
moonshot electron microscope. This instrument will feature a new, dual LPP, a
gun monochromator, aberration correction, an energy filter, and the latest
direct detection camera, with a goal of near-atomic resolution imaging of the
proteome. We are collaborating with Robert Glaser on microscope development;
Eva Nogales, Jim Hurley, Elisabeth Villa, and David Drubin to try out their
most challenging specimens; as well as with ThermoFisher Scientific to
transfer the technology. The project is associated with Quantitative
Biosciences (QB3) at Berkeley, which brings together physical scientists,
engineers, and biologists into a collaborative research environment with
shared resources and core research support facilities.
Lab : https:// matterwave.physics.berkeley.edu/
Basic qualifications (required at time of application)
Candidates must hold a Ph.D. or equivalent international degree or be in the
process of obtaining a Ph.D. or equivalent international degree at the time of
Additional qualifications (required at time of start)
Candidates must have obtained their Ph.D. or equivalent international degree
by the start date of the job. Candidates should have no more than three years
of previous postdoctoral experience by start date in Spring 2022.
A Ph.D. in Physics in experimental physics. Biological electron microscopy, or
innovative use of software for data collection and analysis in the area of
cryo-EM and tomography.
Curriculum Vitae - Your most recently updated C.V.
Statement of Research
2-3 required (contact information only)
Apply link: https: // aprecruit.berkeley.edu/JPF03273
Help contact: firstname.lastname@example.org
Diversity, equity, inclusion, and belonging are core values at UC Berkeley.
Our excellence can only be fully realized by faculty, students, and academic
and non-academic staff who share our commitment to these values. Successful
candidates for our academic positions will demonstrate evidence of a
commitment to advancing equity, inclusion, and belonging.
The University of California, Berkeley is an Equal Opportunity/Affirmative
Action Employer. All qualified applicants will receive consideration for
employment without regard to race, color, religion, sex, sexual orientation,
gender identity, national origin, disability, age, or protected veteran
status. For the complete University of California nondiscrimination and
affirmative action policy see:
In searches when letters of reference are required all letters will be treated
as confidential per University of California policy and California state law.
Please refer potential referees, including when letters are provided via a
third party (i.e., dossier service or career center), to the UC Berkeley
statement of confidentiality (https:// apo.berkeley.edu/ucb-confidentiality-
policy) prior to submitting their letter.
As a condition of employment, you will be required to comply with the
University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy
https: // policy.ucop.edu/doc/5000695/SARS-CoV-2Covid-19. All Covered
Individuals under the policy must provide proof of Full Vaccination or, if
applicable, submit a request for Exception (based on Medical Exemption,
Disability, and/or Religious Objection) or Deferral (based on pregnancy) no
later than the applicable deadline. For new University of California
employees, the applicable deadline is eight weeks after their first date of
employment. (Capitalized terms in this paragraph are defined in the policy.)
Apply now to Postdoctoral Scholar - Department of Physics - University of
California, Berkeley or
Log in to your portfolio
Need help? Contact the hiring department.
The University of California, Berkeley is an Equal Opportunity/Affirmative
Action Employer. You have the right to an equal employment opportunity.
For more information about your rights, see the EEO is the Law Supplement
The University of California, Berkeley is committed to providing reasonable
accommodations to applicants with disabilities.
See our Jeanne Clery Disclosure of Campus Security Policy and Campus Crime
Statistics Act Annual Security Reports