Postdoctoral Researcher

University of Oxford

United Kingdom

September 29, 2022

Description

Postdoctoral Researcher

Department of Oncology, Old Road Campus Research Building, Headington, Oxford, OX3 7DQ

About the role

We have an exciting opportunity for a Postdoctoral Researcher to work on a collaborative project supervised by Profs Ester Hammond and Amato Giaccia in the Department of Oncology. The project will focus on recent work from the Hammond lab, which has characterised the role of R-loops in the biological response to hypoxia (Ramachandran, Ma et al., Nat Comms 2021). Specifically, we plan to focus on aspects of hypoxia-induced transcriptional stress and how this could be exploited to improve the response of hypoxic tumours to radiotherapy.

You will manage your own academic research and administrative activities, which involves small-scale project management to co-ordinate multiple aspects of work to meet deadlines. You will test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate, and adapt existing and develop new scientific techniques and experimental protocols. You will contribute ideas for new research projects and develop ideas for generating research income, presenting detailed research proposals to senior researchers. You will collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters, represent the research group at external meetings/seminars. You will act as a source of information and advice to other members of the group on scientific protocols and experimental techniques, providing guidance to less experienced members of the research group.

The post will be based at the Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ, and is offered on a full-time basis (although part-time hours will be considered), fixed-term until 31 October 2023.

An early start date is required.

About you

You will hold (or be close to completing) a relevant PhD/DPhil in cancer biology, and have previous experience of working in the field of hypoxia research, specifically in the context of resistance to radiation. Detailed knowledge and experience of working with both the DNA damage and unfolded protein responses, including the use of assays to measure DNA damage, R-loops and transcription, is essential for this role. You will possess sufficient specialist knowledge in the discipline to work within established research programmes and previous experience of contributing to publications/presentations, ideally as first or co-first author. You will have proven ability to manage your own academic research and associated activities, together with excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings. Experience with assays to measure oxidative stress and a knowledge of factors which lead to nucleolar stress, would be advantageous.

Application Process

You will be required to upload a supporting statement (setting out how you meet the selection criteria), a curriculum vitae and the names and contact details of two referees as part of your online application.

Informal enquiries about the role can be directed to ester.hammond@oncology.ox.ac.uk

Only applications received by 12pm BST Thursday 29 September 2022 will be considered.

Interviews are expected to take place w/c 03 October 2022. Candidates should be available for interview during this time.

Contact Person : HR Officer Vacancy ID : 159938 Contact Phone : Closing Date & Time : 29-Sep-2022 12:00 Pay Scale : STANDARD GRADE 7 Contact Email : recruitment@oncology.ox.ac.uk Salary (£) : Grade 7: £34,308 - £42,155 per annum

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The University of Oxford is the oldest university in the English-speaking world, and is actually so ancient that its founding date is unknown – though it is thought that teaching took place there as early as the 11th century. It’s...