Postdoctoral Researcher: Rna, Transcription, Coronaviruses, Biochemistry, Bioinformatics

Universities and Institutes of Poland

Poland

October 15, 2022

Description

  • Organisation/Company: Institute of Biochemisty and Biophysics Polish Academy of Sciences
  • Research Field: Biological sciences › Other
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2)
  • Application Deadline: 15/10/2022 00:00 - Europe/Athens
  • Location: Poland › Warsaw
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 40
  • Offer Starting Date: 02/10/2022
  • The laboratory headed by Dr. Tomasz Turowski is looking for a postdoctoral researcher. You will join the project entitled “Functional framework for viral RNA-dependent RNA polymerase, a major target in COVID19 treatment” funded by the Polish National Agency for Academic Exchange grant PPN/PPO/2020/2/00004.

    Our laboratory is interested in how the mechanisms of transcription affects gene regulation and our goal is to apply this knowledge to increase our understanding of SARS-CoV-2 transcription to study viral adaptation and the mechanism of drug inhibition.

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive strand RNA virus, in which the infecting RNA serves both as mRNA and genome. An RNA-dependent RNA polymerase (RdRP) both transcribes the genes and replicates the genome, making RdRP a major target in COVID19 therapy. Nucleotide analogues, including the drugs remdesivir and sofosbuvir, inhibit RNA synthesis by RdRP, but therapy could be enhanced by better understanding of key features of RdRP function.

    To define key elements in SARS-CoV-2 transcription regulation, we will apply the combination of approaches developed in the Lab: in vivo biology, biochemistry and bioinformatics. We aim to map RdRP in non-pathogenic coronaviruses and validate our findings using in vitro methods. Our experiments will be followed by bioinformatics analysis. We aim to identify sequences and mechanisms important for SARS-CoV-2 transcription that can be used as targets in the therapies.

    Job description:

    The successful applicant will be responsible for executing research in the project which may involve both, wet experiments and/or bioinformatics. Wet lab experiments will involve experiments with non-pathogenic coronaviruses and in vitro biochemistry with recombinant proteins of SARS-CoV-2 RdRP. For wet lab researcher training in bioinformatics can be provided. Bioinformatics will involve analysis of high-throughput sequencing data and analysis of sequence features of known coronaviruses.

    Benefits

    We offer:

    • Full-time employment contract until the end of July 2025 with gross salary of 7 500 PLN/month plus 13th salary once a year. Net salary depends on individual circumstances influencing tax. NAWA funding allows additional salaries from NCN funds.

    • The position with 100% focus on research (no teaching obligations).

    • Training opportunities.

    • Good work-life balance culture.

    Eligibility criteria

    The deadline for applications is October 15st, 2022, early applications encouraged. The job starting date is November 1st, 2022 or later.

    Selection process

    Informal inquiries:

    Informal inquiries are very welcome. Please send an email to tomasz.turowski@ibb.waw.pl including any questions, brief description of your motivation and other relevant information (i.e. CV, Google Scholar link).

    Apply now to tomasz.turowski@ibb.waw.pl

    • In the subject include "PostDoc" and your first and last name

    • Your application must be submitted in English and should contain:

    o Cover letter (briefly describing background, interests and motivation, up to 1 page). Generic cover letters will not be considered.

    o Scientific CV including achievements and used methodology (up to 5 pages).

    o Contact details to 2 potential referees, including your PhD supervisor.

    o All documents should be merged in a single pdf file.

    • Please include the following statement in your application: I hereby give my consent for the processing of my personal data by the Institute of Biochemistry and Biophysics PAS with its seat in Warsaw Pawińskiego 5a, 02-106 hereinafter referred to as the Institute for the purpose of the recruitment process and for future recruitment processes conducted by the Institute under Art. 23 ust 1 pkt 1 of the Personal Data Protection Act dated on 29 August 1997, consolidated text: Journal of Laws 2016, item 922 with further amendments and under Art. 6 ust.1 lit. a of Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such GDPR (Dz. U. UE. L. z 2016 r. Nr 119)”

    Selected candidates will be invited for an interview (possible on-line).

    Applications submitted after the deadline will be still considered if the position is not filled.

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: PhD or equivalent

  • REQUIRED LANGUAGES
  • ENGLISH: Excellent

    Skills/Qualifications

    Requirements for the candidate:

    • Passion for science and ability to work independently under appropriate supervision.

    • PhD in biology/biotechnology/bioinformatics or related. There is no limit of years after PhD.

    • Hands-on experience: wet lab or bioinformatics.

    • Proficiency in spoken and written English.

    • Solid knowledge in molecular and cell biology.

    • Previous experience in RNA biology or virology will be of advantage, but is not mandatory.

    • Knowledge of shell command line tools and one of the following languages: python, R, Matlab will be of advantage, but is not mandatory.

    Contact Information
  • Organisation/Company: Institute of Biochemisty and Biophysics Polish Academy of Sciences
  • Department: Laboratory of Transcription Mechanisms
  • Organisation Type: Research Laboratory
  • Website: https: // ibb.edu.pl/en/laboratory/dr-tomasz-turowski/
  • E-Mail: tomasz.turowski@ibb.waw.pl
  • Country: Poland
  • City: Warsaw
  • Postal Code: 02-106
  • Street: ul. Pawińskiego 5a
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