Postdoctoral Researcher – Resistance Mechanisms in Colorectal Cancer

Position: Postdoctoral Researcher – Resistance Mechanisms in

Colorectal Cancer

Department: DKTK Berlin, Charité Universitätsmedizin, Institute of Pathology (Charité Campus Mitte)

Code number: 2023-0001

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

Together with university partners at seven renowned partner sites, we have established the German Cancer Consortium (DKTK). At the partner site of DKTK Berlin the German Cancer Research Center is offering a postdoc position for resistance mechanisms in colorectal cancer.

Job description:

The offered position is part of a collaboration between the research group “Molecular Pathology” at the Institute of Pathology (Charité Campus Mitte) and the Department of Hematology and Oncology (Charité Campus Mitte). The project´s aim is centered on the functional understanding of molecular processes that drive resistance to novel clinical KRAS inhibitors in cancer. We employ genomic and imaging-based assays to decipher the adaptation and resistance of tumors from patients that developed a resistance to KRAS inhibition. The tasks associated with this position will involve but are not limited to:

Establishing of organoid lines from patient samples

Performing DNA and RNA analysis of organoid and patient samples

Applying small drug and CRISPR screen to identify sensitivities of patient-derived organoids

Performing multiplex imaging on patient samples

Mapping signaling networks of patient-derived organoids

Validation experiments (including qPCR, Western blotting, FACS, CyTOF)

Requirements:

Excellent PhD degree in biology, cancer biology, systems biology, molecular biology, biomedical engineering, or related disciplines

Highly motivated to apply your own skills and expand your knowledge to develop innovative approaches for clinically relevant research questions

Knowledge in oncology and related disciplines

Experience in the analysis of next-generation sequencing data is an advantage

Team-oriented and reliable with interdisciplinary communication skills

Independent and creative working and effective time management

Excellent English language skills

If you have any questions regarding the application process, please contact Anja Hernández, phone +49 (0)761 270-22810. If you have any questions regarding the content of the position, please contact Dr. Björn Papke, email [email protected]

We offer:

Interesting, versatile workplace

International, attractive working environment

Campus with modern state-of-the-art infrastructure

Salary according to TV-L including social benefits

Possibility to work part-time

Flexible working hours

Comprehensive further training program

Access to the DKFZ International Postdoc Program

Important notice:

The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles may work at the DKFZ.

Earliest possible start date: as soon as possible

Duration: The position is initially limited to 2 years. ​

The position can in principle be part-time.

Application deadline: 25.01.2023

Contact:

Dr. Anja Hernández Phone +49 (0)761/270-22810

Please note that we do not accept applications submitted via email.

The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.

Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (https: // www. dkfz.de/en/stellenangebote/index.php).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.