Postdoctoral Researcher: Regulation of human NK cell differentiation

Karolinska Institute Stockholm

Sweden

November 26, 2021

Description

Do you want to contribute to top quality medical research?

Karolinska Institutet, Department of Medicine, Center for Hematology and Regenerative Medicine

We are seeking a highly motivated and ambitious individual to join the research group of Yenan Bryceson as a Postdoctoral Fellow to further elucidate primary immunodeficiency diseases and decipher the molecular regulation of human NK cell differentiation and memory. Our ambition is to develop future research leaders.

Your mission

Previously considered an arm of the innate immune system, recent studies from our group (Schlums, et al., Immunity 2015; Schlums, et al., Blood 2017; Wu et al., Sci Immunol 2018; Holmes et al., Sci Immunol 2021) as well as others have uncovered distinct NK cell differentiation and memory processes. We seek further understanding of NK cell development and immunological memory, which can explain life-threatening primary immunodeficiency disease (PID) syndromes and can be harnessed for cellular immunotherapy of cancer. A successful postdoctoral candidate will be involved in PID diagnostics and exploring novel molecular aspects of human NK cell biology, derived from insights from studies of primary immunodeficiency patients as well as transcriptional and epigenetic analyses. Methods will include advanced flow cytometry and sorting, analyses of chromatin structure and epigenetic modifications, single-cell RNA-seq, genetic manipulation, and functional analyses.

The research group is based at the Center of Hematology and Regenerative Medicine (HERM), Karolinska Institutet. HERM consists of approximately 90 research fellows and is a nationally leading and internationally competitive environment for studies of the human immune system in the context of malignancy and infectious diseases. The vision is to become one of the leading translational research centers within hematopoiesis and immunity in Europe. The laboratory offers state-of-the art cell culture, molecular biology, flow cytometry and microscopy facilities. You can benefit from access to state-of- the-art core facilities at Karolinska Institutet. In the Bryceson group (https:// www. ki.se/en/medh/yenan-bryceson-group), you will be working in a very international and interdisciplinary research environment, where collaborative efforts are encouraged.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

Entry requirements, skills, and personal qualities

Qualification requirements

  • PhD or MD-PhD degree with previous research experience
  • First authorship papers in high-ranking, peer-reviewed journals
  • Fluent oral and written communication skills in English
  • Skills that count in the assessment

  • Experience in using a variety of molecular biology technologies
  • Experience in using a high-throughput sequencing, transcriptomics, epigenetics
  • Experience working with primary cells
  • Knowledge of lymphocyte biology
  • Knowledge and experience of bioinformatics
  • Personal fit
  • Personal qualities

  • Hard-working and driven
  • Organized
  • Self-directed and independent
  • Creative
  • Collaborative, team player
  • Duties and work tasks

  • Elaboration of scientific hypothesis, experimental design
  • Flow cytometry analysis and sorting
  • Design and conduct transcriptional and epigenetic analyses
  • Presentation and publication of results
  • Terms

    This is a full-time fixed-term appointment for 12 months, with possibilities for extension depending on scientific progress. Positions are available immediately, offering competitive fellowships.

    What do we offer?

    Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

    Location: Flemingsberg

    The department of Medicine in Huddinge

    Center for Hematology and Regenerative Medicine

    Yenan Bryceson group

    Application

    An employment application must contain the following documents in English:

  • A letter of motivation explaining the interest in the position and including a summary of why the applicant's background and experience would be relevant for the project.
  • A complete curriculum vitae, including date of the thesis defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work.
  • A complete list of publications.
  • A synopsis of current research work (no more than one page).
  • Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application deadline).
  • Welcome to apply at the latest 2021-11-26.

    The application is to be submitted through the Varbi recruitment system.

    Want to make a difference? Join us and contribute to better health for

    all

    Type of employment Temporary position longer than 6 months
    Contract type Full time
    First day of employment According to agreement
    Salary Monthly salary
    Number of positions 1
    Working hours 100%
    City Flemingsberg Campus
    County Stockholms län
    Country Sweden
    Reference number STÖD 2-4912/2021
    Contact
    • Yenan Bryceson, yenan.bryceson@ki.se
    Union representative
    • Belinda Pannagel, SACO, Belinda.pannagel@ki.se
    • Elisabeth Henriksson, OFR, Elisabeth.henriksson@ki.se
    • Mari Gilljam, OFR, Mari.gilljam@ki.se
    Published 12.Nov.2021
    Last application date 26.Nov.2021 11:59 PM CET

    Similar Jobs

    Add to favorites Read more...

    Post-Doctoral Position In Cell Therapy

    The post-doctoral researcher will work under the supervision of the lab Activities will include scientific survey, primary cell cultures, flow and at Smart Immune (Paris Biotech Santé). • PhD in cell biology and/or biochemistry obtained...

    Göteborg University

    Sweden Nov 9, 2021

    Add to favorites Read more...

    Doctoral Student In Medical Science - Immunology

    The University of Gothenburg tackles society's challenges with diverse knowledge and new perspectives, the University contributes to a better future. project and completing at least 30 credits of courses at third-cycle level. The doctoral student...

    Add to favorites Read more...

    Post-Doctoral Position In Cell Biology And Biophysics

    Research Field: Biological sciences › Biology engineering, live-cell imaging, microfluidics and analysis of physical experiments, interpret the results and propose new approaches to fully develop Perform live-cell imaging assays by confocal microscopy (multi-color time- the...

    University of Illinois at Chicago

    United States Nov 11, 2021

    Add to favorites Read more...

    Postdoctoral Research Associate - Department of Medicine, Division of Hematology/Oncology

    Postdoctoral Research Associate - Department of Medicine, Division of A post-doctoral position is available in the Division of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago for an American transcription factor FOXM1 in Acute...