Do you want to contribute to top quality medical research?
Karolinska Institutet, Department of Medicine, Center for Hematology and
We are seeking a highly motivated and ambitious individual to join the
research group of Yenan Bryceson as a Postdoctoral Fellow to further elucidate
primary immunodeficiency diseases and decipher the molecular regulation of
human NK cell differentiation and memory. Our ambition is to develop future
Previously considered an arm of the innate immune system, recent studies from
our group (Schlums, et al., Immunity 2015; Schlums, et al., Blood 2017; Wu et
al., Sci Immunol 2018; Holmes et al., Sci Immunol 2021) as well as others
have uncovered distinct NK cell differentiation and memory processes. We seek
further understanding of NK cell development and immunological memory, which
can explain life-threatening primary immunodeficiency disease (PID)
syndromes and can be harnessed for cellular immunotherapy of cancer. A
successful postdoctoral candidate will be involved in PID diagnostics and
exploring novel molecular aspects of human NK cell biology, derived from
insights from studies of primary immunodeficiency patients as well as
transcriptional and epigenetic analyses. Methods will include advanced flow
cytometry and sorting, analyses of chromatin structure and epigenetic
modifications, single-cell RNA-seq, genetic manipulation, and functional
The research group is based at the Center of Hematology and Regenerative
Medicine (HERM), Karolinska Institutet. HERM consists of approximately 90
research fellows and is a nationally leading and internationally competitive
environment for studies of the human immune system in the context of
malignancy and infectious diseases. The vision is to become one of the leading
translational research centers within hematopoiesis and immunity in Europe.
The laboratory offers state-of-the art cell culture, molecular biology, flow
cytometry and microscopy facilities. You can benefit from access to state-of-
the-art core facilities at Karolinska Institutet. In the Bryceson group
(https:// www. ki.se/en/medh/yenan-bryceson-group), you will be working in a
very international and interdisciplinary research environment, where
collaborative efforts are encouraged.
Qualified to be employed as a postdoctor is one who has obtained a doctorate
or has equivalent scientific competence. Applicants who have not completed a
doctorate at the end of the application period may also apply, provided that
all requirements for a completed degree are met before the (intended) date
of employment. This must be substantiated by the applicant's main supervisor,
director or equivalent.
Entry requirements, skills, and personal qualities
PhD or MD-PhD degree with previous research experience
First authorship papers in high-ranking, peer-reviewed journals
Fluent oral and written communication skills in English
Skills that count in the assessment
Experience in using a variety of molecular biology technologies
Experience in using a high-throughput sequencing, transcriptomics,
Experience working with primary cells
Knowledge of lymphocyte biology
Knowledge and experience of bioinformatics
Hard-working and driven
Self-directed and independent
Collaborative, team player
Duties and work tasks
Elaboration of scientific hypothesis, experimental design
Flow cytometry analysis and sorting
Design and conduct transcriptional and epigenetic analyses
Presentation and publication of results
This is a full-time fixed-term appointment for 12 months, with possibilities
for extension depending on scientific progress. Positions are available
immediately, offering competitive fellowships.
What do we offer?
Karolinska Institutet is one of the world's leading medical universities. Our
vision is to pursue the development of knowledge about life and to promote
better health for all. At Karolinska Institutet, we conduct innovative medical
research and provide the largest range of biomedical education in Sweden.
Karolinska Institutet is a state university, which entitles employees to
several benefits such as extended holiday and a generous occupational pension.
Employees also have free access to our modern gym and receive reimbursements
for medical care.
The department of Medicine in Huddinge
Center for Hematology and Regenerative Medicine
Yenan Bryceson group
An employment application must contain the following documents in English:
A letter of motivation explaining the interest in the position and
including a summary of why the applicant's background and experience would
be relevant for the project.
A complete curriculum vitae, including date of the thesis defense, title
of the thesis, previous academic positions, academic title, current
position, academic distinctions, and committee work.
A complete list of publications.
A synopsis of current research work (no more than one page).
Verification from the thesis defense committee or the equivalent (only if
the thesis defense is scheduled within three months after the application
Welcome to apply at the latest 2021-11-26.
The application is to be submitted through the Varbi recruitment system.
Want to make a difference? Join us and contribute to better health for
|Type of employment
||Temporary position longer than 6 months
|First day of employment
||According to agreement
|Number of positions
|Last application date
||26.Nov.2021 11:59 PM CET