Postdoctoral researcher Peptide therapeutics
Are you interested in peptide synthesis and therapeutics? Are you looking for
a challenging research project with potential for translation in biomedicine?
Do you want to work independently as part of a multidisciplinary and
Chemical Engineering and Chemistry
Despite progress in infection treatment in the last decades, the prevalence
and mortality of infections still poses a heavy burden over humankind. The
development of antimicrobial resistance and the rapid mutagenesis of bacteria
that leads to inefficiency of vaccines, play an important role in maintaining
infections high level of threat. Even diseases that have plagued us for
centuries, such as cholera, still challenge medical professionals and cause a
significant social cost. New therapeutic approaches that promise a higher
success rate are a pressing need. We recently discovered peptides which bind
and block the RTX adhesin (FrhA) used by the bacteria of cholera to attach
to and infect the human intestine, suggesting these peptides could help
prevent cholera's infection. By blocking FrhA, these peptides could also
potentially detach already adhered bacteria, effectively removing cholera and
curing the disease. Moreover, FrhA is similar to the RTX adhesin of most gram-
negative bacteria, including those in the priority list of the WHO (E. coli,
K. pneumoniae). In this project you will optimise the synthesis and
characterisation of the discovered peptides, and in collaboration with our
partners demonstrate blockage of cholera adhesion in an in vitro cellular
model. You will also explore whether a similar strategy is applicable to other
PhD in peptide science. Experience with peptide synthesis, peptide
characterisation, peptide therapeutics, and protein crystallography;
knowledge of fluorescence polarization spectroscopy (FP), isothermal
calorimetry (ITC), and infectious diseases like cholera is preferred.
Ability to conduct high quality academic research, demonstrated by an
outstanding PhD thesis and publications in peer-reviewed journals.
Strong motivation to do excellent, original, fundamental research with the
potential for translation in biomedicine.
Excellent mastering of the English language, good communication and
leadership skills. Note that there is no Dutch language requirement.
Independent and goal-oriented scientist. Team player and able to work in a
dynamic, interdisciplinary, and international context.
Conditions of employment
A meaningful job in a dynamic and ambitious university with the
possibility to present your work at international conferences.
A full-time employment for 1 year.
You will have free access to high-quality training programs for research,
valorization and professional development
A gross monthly salary and benefits in accordance with the Collective
Labor Agreement for Dutch Universities.
A broad package of fringe benefits (including an excellent technical
infrastructure, moving expenses, and savings schemes).
Family-friendly initiatives are in place, such as an international spouse
program, and excellent on-campus children day care and sports facilities.
Information and application
For further information on this vacancy please contact
Prof. Dr. Ir. Ilja Voets, i.voetsattue.nl or +31 40 247 5303
For information about terms of employment, please contact Leo van Houten,
l.v.houtenattue.nl or +31 40 247 8269
Please visit www. tue.nl/jobs to find out more about working at TU/e!
We invite you to submit a complete application by using the 'apply now'-button
on this page. The application should include a:
Cover letter in which you describe your motivation and qualifications for the
Curriculum vitae, including a list of your publications and the contact
information of three references.
A letter of recommendation from one or more of your references.
List of five self-selected ‘best publications'.
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necessary, please combine files.
We look forward to your application and will screen it as soon as we have
received it. Screening will continue until the position has been filled.