Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Headington, Oxford, OX3 9DU
Contract type: Fixed term for 12 months
About the role
You will work on a new, translational project, funded by the MRC Confidence in Concept fund and industry partner, Oxford Biomedica, to generate antigen- specific, human regulatory B cells (Breg). You will be responsible for the development and implementation of lentiviral platforms and CRISPR/Cas9 techniques to deliver genes encoding B cell receptor constructs to primary human B cells. Successful realisation of this project will demonstrate proof of concept design of precision B cell therapies in transplantation and immune- mediated disorders. You will be based within the Nuffield Department of Surgical Sciences in the John Radcliffe Hospital, as your normal place of work.
This position offers a unique opportunity to contribute to the work of an internationally recognised team of scientists and clinicians within the Translational Research Immunology Group (TRIG). TRIG has extensive experience in studying and translating regulatory cell therapy from the bench to the bedside as new treatments for transplant recipients. Breg have been shown to have key roles in defining outcomes in organ transplantation and autoimmune disease. TRIG has developed new methods of expanding human Breg in vitro, to enable in depth study and therapeutic development.
You will hold a PhD (or be near to completion: thesis submitted) in a relevant area such as cellular or molecular biology at the time of application. Experience with genetic editing techniques such as vector manufacture, viral transfection, PCR and sequencing is desirable but not essential. You will have demonstrated the ability to work independently within projects, with the ability to communicate results clearly and succinctly in presentations, manuscripts and grant applications.
This position is available from February 2023, fixed-term for 12 months and is funded by the Medical Research Council Confidence in Concept & Oxford Biomedica.
If you would like to discuss this role, please contact the Human Resources team on [email protected]
Applications for this vacancy are to be made online. You will be required to upload a supporting statement, setting out how you meet the selection criteria, curriculum vitae and the names and contact details of two referees as part of your online application. Please quote reference NDSA876B on all correspondence.
Only applications received before noon 2023 can be considered.
Interviews will be held weeks commencing Thursday 23 February 2023.
Committed to equality and valuing diversity
Contact Person : Shelley Hammond Vacancy ID : 163096 Contact Phone : 01865 612269 Closing Date & Time : 13-Feb-2023 12:00 Pay Scale : STANDARD GRADE 7 Contact Email : [email protected] Salary (£) : Grade7: £34,308 - £42,155 per annum