Organisation/Company: Nencki Institute of Experimental Biology
Research Field: Biological sciences Chemistry Neurosciences
Researcher Profile: Recognised Researcher (R2) Established
Application Deadline: 30/09/2022 23:00 - Europe/London
Location: Poland › Warsaw
Type Of Contract: Temporary
Job Status: Full-time
Hours Per Week: 40
The Nencki Institute of Experimental Biology PAS is seekinga candidate for
the position of:
Postdoctoral Researcher in Laboratory of Cell Biophysics
Place of work: Nencki Institute of Experimental Biology PAS
Type of recruitment: National Science Centre Sonata BIS project
Scope of tasks:
Description of the role and the time-course of S-PALM in learning, memory and
The hallmark of the mammalian brain is the ability of processing and storing
information in synapses and highly organized neuronal networks. The brain can
adapt and change in response to various events under physiological conditions
(i.e. learning) and pathophysiological conditions (i.e. epilepsy, stroke).
Understanding the fundamental mechanisms of the plasticity of synaptic
connections and neuronal network code lies in the center of contemporary
neurobiology, neuropharmacology, and medicine. Targeting proteins to membranes
is aided by covalent and reversible addition of fatty acids such as palmitic
acid (S-palmitoylation). This modification may affect the membrane
localization of the protein, protein activity and protein-protein
interactions. We hypothesize this process plays a key role in learning and
memory, because pharmacological modification of S-palmitoylation in rat
nervous tissue abolished long-term synaptic potentiation, a substrate of
memory formation. We have also discovered, that spatial learning in rats is
associated with S-palmitoylation of specific neuronal proteins.
The project aims at describing the interaction of neurotransmitter dopamine
and S-palmitoylation of synaptic proteins in the hippocampus- part of the
brain playing crucial role in learning. In the team consisting of experts of
various fields, we combine multiple experimental techniques: detection of
modified proteins with mass spectrometry, genetic and pharmacological
manipulation of activity of enzymes related to palmitoylation, behavioral
analysis of learning in animals. We perform live recordings of electric
signals from synapses, single neurons and neuronal networks and currents
conducted by synaptic proteins to better understand the functional aspects of
palmitoylated vs non-palmitoylated states.
Taking advantage of various experimental models and advanced quantitative
methods we plan to address the following questions:
What is the role and time-course of S-palmitoylation in synaptic plasticity?
How dopamine affects S-palmitoylation of synaptic proteins?
What is the effect of S-palmitoylation of the function of proteins involved in
learning and memory?
The results of this project will shed new light on the general mechanisms
governing brain plasticity and may be also important for the understanding of
dopamine role in brain physiology as well as planning new therapeutic
strategies for the treatment of some neurological diseases.
type of contract: full-time fixed term contract appointment
duration of contract: 30 months
commencement of employment:
Work in an young team in an excellent scientific environment
Access to the state-of-the-art equipment and facilities dedicated to
neuroscience research. The laboratory is located at the at the Nencki
Institute of Polish Academy of Sciences in Warsaw, Poland. It is a leading
research institute in Poland focused on different aspects of physiology and
neurobiology and offers state-of-the-art research facilities and a vibrant,
international scientific community: https: // www. nencki.edu.pl/
Participation in courses and conferences
Comprehensive training in electrophysiological recordings
training and visits in collaborating laboratories in Poland and abroad
additional benefits: medical insurance, possibility to use sport card, social
fund. The Institute is located at Ochota academic campus close to the center
of the city with free bicycle and car parking lot.
Application procedure and deadline: applicants should contact via e-mail
provided below. Individual conversations will be scheduled online.
Required documents: CV, description of professional experience with emphasis
on research techniques used by the applicant, list of publications, letter-of-
You can use the foreign equivalent of a Polish academic degree if it meets at
least one of the following criteria:
• is covered by the provisions of an international agreement on the
equivalence of education,
• was issued by an authorized institution operating in an EU, OECD or EFTA
• was issued in another country and recognized on the basis of the regulations
on the recognition of academic degrees obtained abroad (learn more about the
procedure for the recognition of academic degrees:
https: // nawa.gov.pl/en/recognition/recognition-for-professional-
Applications should be sent to : firstname.lastname@example.org with note “NCN Sonata
The deadline is Sept 30th, 2022
Informal inquires can be sent to the principal investigator: Tomasz Wójtowicz,
Link to website:
https: // sites.google.com/nencki.edu.pl/cell-biophysics-lab/
https: // www. nencki.edu.pl/laboratories/laboratory-of-cell-biophysics/
Please include the following clause in your CV:
“I give consent for my personal data included in the recruitment form to be
processed by Nencki Institute of Experimental Biology PAS with its registered
seat in Warsaw at Pasteur Street No. 3 (data controller) for the purposes of
recruitment for Postdoctoral Researcher position pursuant to Regulation (EU)
2016/679 of the European Parliament and of the Council of 27 April 2016 on the
protection of natural persons with regard to the processing of personal data
and on the free movement of such data, and repealing Directive 95/46/EC in
compliance with a legal obligation to which the data controller is subject to
(Art. 6 section 1 letter a) and the Act on personal data protection of 10
May 2018 (Journal of Laws of 2018, item 1000).”
The Controller of data is Nencki Institute of Experimental Biology PAS with
its registered seat in Warsaw at Pasteur Street No. 3.
Contact Details of the Personal Data Protection Officer: email@example.com
Personal data in the recruitment form is collected and will be processed only
for the purposes of recruitment for post-doc position conducted by Nencki
Institute of Experimental Biology PAS.
Giving consent for processing of your personal data is voluntary; however, it
is necessary in order to take part in recruitment. I hereby state that I was
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Personal data collected in order to perform the recruitment process shall be
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complaint; however, not longer than up to 31.12.2022.
Personal data will not be transferred to a third party.
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REQUIRED EDUCATION LEVEL
Biological sciences: PhD or equivalent
Chemistry: PhD or equivalent
Neurosciences: PhD or equivalent
Education: PhD in chemistry, biology, biotechnology, neurobiology or similar
received < 7 years ago
professional experience: experience in experimental work in the laboratory,
strong publication record
skills: creativity and analytical thinking, experience in the application of
methods of cell biology, experience in animal handling and behavioral studies
or related. Skills in genetic manipulations or biochemistry, proteomics, mass
spectrometry or programming are additional attributes.
competences: ability to work both independently and as a part of a team,
independence in planning, performing experiments and data analysis, excellent
verbal communication skills
Organisation/Company: Nencki Institute of Experimental Biology
Organisation Type: Public Research Institution
Website: https:// www. nencki.edu.pl
Street: 3 Pasteur St.