Postdoctoral Researcher In Host-Microbiota/Pathogen Interaction (# Of Pos: 2)

Universities and Institutes of France
December 24, 2022
Contact:N/A
Offerd Salary:Negotiation
Location:N/A
Working address:N/A
Contract Type:Temporary
Working Time:Full time
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Job Ref.:N/A
  • Organisation/Company: INSERM
  • Research Field: Biological sciences › Biology
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 24/12/2022 22:00 - Europe/Brussels
  • Location: France › Paris
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 40
  • Offer Starting Date: 01/03/2023
  • Eu Research Framework Programme: H2020 / ERC
  • Reference Number: 866222 NICHEADAPT
  • The laboratory of Host-Microbiota Interaction, headed by Pamela Schnupf, at INEM (https: // www. institut-necker-enfants-malades.fr) in central Paris, France, is recruiting a postdoctoral researcher for up to three years or longer on the ERC CoG-funded project NicheAdapt.

    The project NicheAdapt focuses on the characterization of the unique niche adaptations and interactions of the unusual commensal bacterium Segmented Filamentous Bacteria (SFB) with its host. SFB is highly unusual Clostridium- related commensal that is ubiquitously found in vertebrates and potently affects the host immune system. SFB has the atypical feature of intimate attachment to the host ileum, a normally pathogenic feature, without inducing pathology. The potent SFB-elicited immune stimulation promotes the postnatal development of intestinal lymphoid tissue and induces a state of physiological inflammation characterized by a strong Tb7 cell response and enhanced colonization resistance to pathogens. Our work uses a combination of wild-type and knock-out gnotobiotic mouse models, in vitro hypoxic growth conditions and a variety of “omics”. We are particularly interested in the unusual attachment of the bacterium to its host and the bacterial and host factors involved. This work will give critical insights into the cross-talk between the host and the gut microbiota and will address unknown features of the unusual life-cycle of SFB and mechanisms underlying gut immune homeostasis.

    Benefits

    A competitive postdoctoral salary in accordance with the applicant's previous research experience is offered in accordance with government regulations.

    Eligibility criteria

    The candidate is expected to speak and write English fluently, easily work in a multicultural environment, and be passionate about science and creative problem solving.

    Selection process

    Interested applicants are invited to inquire or to submit an application to pamela.schnupf@inserm.fr with the subject heading: “LASTnameFirstnamePostdocNiche” including a PDF with: 1. a cover letter with a description of the applicant's research background, motivation and future interests; 2. a CV; and 3. contact information for at least two referees who can be contacted if the applicant is pre-selected for an interview.

    Additional comments

    The postdoc offer remains open until the position has been filled.

    Required Research Experiences
  • RESEARCH FIELD
  • Biological sciences › Biology

  • YEARS OF RESEARCH EXPERIENCE
  • 1 - 4

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: PhD or equivalent

  • REQUIRED LANGUAGES
  • ENGLISH: Excellent

    Skills/Qualifications

    We are interested in candidates with a solid background in host-pathogen interaction or immunology/mucosal immunology and cell biology while technical expertise in gnotobiology, molecular biology and bacteriology would be advantageous.

    Specific Requirements

    The candidate must have a PhD and should be highly motivated, self-driven, independent and creative with strong organizational, writing and communications skills.

    Contact Information
  • Organisation/Company: INSERM
  • Department: UMRS1151 - Laboratory of Host-Microbiota Interaction
  • Organisation Type: Public Research Institution
  • Website: https: // www. institut-necker-enfants-malades.fr
  • E-Mail: pamela.schnupf@inserm.fr
  • Country: France
  • City: Paris
  • State/Province: Ile de France
  • Postal Code: 75015
  • Street: 160 rue de Vaugirard
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