Postdoctoral Researcher in Genetic Vaccines

University of Oxford
December 15, 2022
Offerd Salary:£34,308 - £42,155
Working address:N/A
Contract Type:fixed term contract
Working Time:Full time
Working type:N/A
Job Ref.:N/A
Postdoctoral Researcher in Genetic Vaccines

Jenner Institute, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ

An exciting Postdoctoral Researcher in Genetic Vaccines position is available in the laboratory of Dr. César López-Camacho, within the recently established mRNA vaccine group at the Jenner institute in the University of Oxford.

You will work in the development of novel mRNA and viral-vectored vaccines for the efficient delivery of antigenic cargos and the induction of protective immune responses against pathogens for which vaccines are not yet available or are suboptimal. Studies will primarily focus on the engineering and characterization of new mRNA vaccine platforms against a broad range of infectious diseases.

In this position, you will contribute technical and intellectual input to the development of novel mRNA-based approaches for second-generation vaccines that are able to offer better potency and stability. This post will help to shape the next generation of mRNA-based platform vaccines.

You will make use of molecular cloning strategies and cell biology for the design of such mRNA and viral-vectored vaccines. In-vitro transcription, mRNA modifications, mRNA purification and mRNA encapsulation will be the main activities for this post. Further studies will involve the assessment of induction of CD4+, CD8+, and B cell phenotypes; and durability, and cross- reactivity during vaccination in pre-clinical models. For this, the postholder will use a broad array of B and T cell experimental approaches including EliSPOT, cytokine arrays, flow cytometry, ELISA, neutralisation assays etc.

The successful applicant will hold a PhD/DPhil (or close to completion) in Biochemistry, Molecular Biology, or related field, together with relevant and proven wet-lab experience in mRNA biology, biogenesis, biosynthesis and modifications for de novo mRNA synthesis. You will possess sufficient specialist knowledge in cellular and molecular biology, with experience working with DNA, in vitro transcription, RNA and biochemistry modification of nucleotide molecules. Having excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings is also essential. This project involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. You will conduct rigorous scientific research to the highest standards of the field. You will act as a source of information and advice to other members of the group on scientific protocols and experimental techniques. Full training will be given for unfamiliar immunological assays.

Applications for this vacancy are to be made online and you will be required to upload the following:

1) A supporting statement. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please carefully read the essential criteria in the Job Description attached below.

2) A full CV as part of your online application.

This position is offered full time on a fixed term contract for 12 months, with high chances for renewal for another 12 months and is funded by the JFF grant and the Department.

Only applications received before 12 midday on Thursday 15 December 2022 will be considered. Please quote 162046 on all correspondence.

Contact Person : Margarita Monroy Vacancy ID : 162046 Contact Phone : 01865287757 Closing Date & Time : 15-Dec-2022 12:00 Pay Scale : STANDARD GRADE 7 Contact Email : [email protected] Salary (£) : £34,308 - £42,155 with a discretionary range to £46,047 per annum

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