Postdoctoral Researcher In Computational Biophysics

Universities and Institutes of Poland

Poland

January 31, 2022

Description

  • Organisation/Company: Institute of Physics, Polish Academy of Sciences, Warsaw
  • Research Field: Physics › Biophysics
  • Researcher Profile: Recognised Researcher (R2)
  • Application Deadline: 31/01/2022 23:00 - Europe/Brussels
  • Location: Poland › 02-668 Warsaw
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 40
  • Offer Starting Date: 01/02/2022
  • Reference Number: Job ID: #JOB 56/2021
  • Job Summary:

    The postdoctoral researcher will join the Division of Theoretical Physics at the Institute of Physics, Polish Academy of Sciences, to participate in the research project on “Biomolecular condensates of galectin-3” supported by the National Science Centre. The postdoctoral researcher will perform molecular dynamics simulations of galectin-3 condensates – both in aqueous solutions and at lipid membranes – using the MARTINI coarse-grained model.

    Job Description:

    Galectins are proteins involved in many biological functions, including immune responses, cell migration and signaling. The multiple biological functions of galectins stem from their interactions with diverse glycoproteins and glycolipids. In mammals, the galectin family consists of 15 members. Galectin-3 is unique within this protein family because of its peculiar molecular architecture. Galectin-3 has been reported to be involved in numerous intra- and extracellular processes, including endocytosis.

    The molecular mechanisms underlying the galectin-3-dependent endocytosis remain elusive. Very recently, however, galectin-3 has been demonstrated to undergo liquid-liquid phase separation (LLPS), which sheds new light on how this protein can perform its biological functions. The objectives of the project are: (i) to explore the intra- and inter-molecular interactions that drive the LLPS of galectin-3, (ii) to give a detailed description of the molecular architecture of galectin-3 condensates in aqueous solutions and at membrane surfaces, and (iii) to explain the molecular mechanisms underlying the membrane bending and endocytic pit formation by the galectin-3 biomolecular condensates. The postdoctoral researcher will contribute towards achieving the objectives of the project using molecular dynamics methods within the framework of the MARTINI coarse-grained model.

    Requirements:

    - PhD in physics or a related branch of science;

    - communicativeness and good command of spoken and written English;

    - diligence at work and consistency in achieving results;

    - knowledge of statistical physics;

    - good knowledge of numerical methods in molecular biophysics and/or chemistry;

    - experience with molecular dynamics simulations of biological macromolecules;

    - experience with the GROMACS package and the MARTINI force field will be considered strong assets.

    Selection process

    Application deadline: January 31, 2022. Applications after the deadline are not considered.

    Required materials:

    • PhD diploma or an explanation of when one is expected

    • Curriculum Vitae • List of publications • Motivation letter • Contact data (e-mail) to at least two potential referees • Consent to process your personal data (expressed on the form attached to this announcement).

    All materials should be submitted in electronic form to the address: rekrutacja@ifpan.edu.pl with Job ID in the subject.

    Additional comments

    Main research field: Physics

    Sub Research Field: Theoretical Biophysics

    Career Stage: PhD in physics or a related discipline obtained no earlier than in 2015

    Institute of Physics of the Polish Academy of Sciences

    OPEN POSITION

    Research Profile (details): Recognized Researcher (R2)

    Type of Contract: Temporary

    Appointment: 30 months

    Status: Full-time

    Salary: 10000 PLN per month (before taxes)

    Contact

    More information can be obtained from Bartosz Różycki (email: rozycki@ifpan.edu.pl). Please make contact.

    Contact Information
  • Organisation/Company: Institute of Physics, Polish Academy of Sciences, Warsaw
  • Department: Scientific Secretariat - -
  • Organisation Type: Public Research Institution
  • Website: https:// info.ifpan.edu.pl/BIP
  • Country: Poland
  • City: 02-668 Warsaw
  • Street: al. Lotników 32/46
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