Description
Organisation/Company: Institute of Physics, Polish Academy of
Sciences, Warsaw
Research Field: Physics › Biophysics
Researcher Profile: Recognised Researcher (R2)
Application Deadline: 31/01/2022 23:00 - Europe/Brussels
Location: Poland › 02-668 Warsaw
Type Of Contract: Temporary
Job Status: Full-time
Hours Per Week: 40
Offer Starting Date: 01/02/2022
Reference Number: Job ID: #JOB 56/2021
Job Summary:
The postdoctoral researcher will join the Division of Theoretical Physics at
the Institute of Physics, Polish Academy of Sciences, to participate in the
research project on “Biomolecular condensates of galectin-3” supported by the
National Science Centre. The postdoctoral researcher will perform molecular
dynamics simulations of galectin-3 condensates – both in aqueous solutions and
at lipid membranes – using the MARTINI coarse-grained model.
Job Description:
Galectins are proteins involved in many biological functions, including immune
responses, cell migration and signaling. The multiple biological functions of
galectins stem from their interactions with diverse glycoproteins and
glycolipids. In mammals, the galectin family consists of 15 members.
Galectin-3 is unique within this protein family because of its peculiar
molecular architecture. Galectin-3 has been reported to be involved in
numerous intra- and extracellular processes, including endocytosis.
The molecular mechanisms underlying the galectin-3-dependent endocytosis
remain elusive. Very recently, however, galectin-3 has been demonstrated to
undergo liquid-liquid phase separation (LLPS), which sheds new light on how
this protein can perform its biological functions. The objectives of the
project are: (i) to explore the intra- and inter-molecular interactions that
drive the LLPS of galectin-3, (ii) to give a detailed description of the
molecular architecture of galectin-3 condensates in aqueous solutions and at
membrane surfaces, and (iii) to explain the molecular mechanisms underlying
the membrane bending and endocytic pit formation by the galectin-3
biomolecular condensates. The postdoctoral researcher will contribute towards
achieving the objectives of the project using molecular dynamics methods
within the framework of the MARTINI coarse-grained model.
Requirements:
- PhD in physics or a related branch of science;
- communicativeness and good command of spoken and written English;
- diligence at work and consistency in achieving results;
- knowledge of statistical physics;
- good knowledge of numerical methods in molecular biophysics and/or
chemistry;
- experience with molecular dynamics simulations of biological
macromolecules;
- experience with the GROMACS package and the MARTINI force field will be
considered strong assets.
Selection process
Application deadline: January 31, 2022. Applications after the deadline are
not considered.
Required materials:
• PhD diploma or an explanation of when one is expected
• Curriculum Vitae • List of publications • Motivation letter • Contact data
(e-mail) to at least two potential referees • Consent to process your
personal data (expressed on the form attached to this announcement).
All materials should be submitted in electronic form to the address:
rekrutacja@ifpan.edu.pl with Job ID in the subject.
Additional comments
Main research field: Physics
Sub Research Field: Theoretical Biophysics
Career Stage: PhD in physics or a related discipline obtained no earlier than
in 2015
Institute of Physics of the Polish Academy of Sciences
OPEN POSITION
Research Profile (details): Recognized Researcher (R2)
Type of Contract: Temporary
Appointment: 30 months
Status: Full-time
Salary: 10000 PLN per month (before taxes)
Contact
More information can be obtained from Bartosz Różycki (email:
rozycki@ifpan.edu.pl). Please make contact.
Contact Information
Organisation/Company: Institute of Physics, Polish Academy of
Sciences, Warsaw
Department: Scientific Secretariat - -
Organisation Type: Public Research Institution
Website: https:// info.ifpan.edu.pl/BIP
Country: Poland
City: 02-668 Warsaw
Street: al. Lotników 32/46
