Postdoctoral researcher Engineered ice-binders

Eindhoven University of Technology

Netherlands

August 15, 2021

Description

Postdoctoral researcher Engineered ice-binders

Are you fascinated by ice-binding proteins? Are you interested in (computer- aided) protein engineering, ice crystal growth, and biomineralization?Are you passionate about your research?Do you want to work in a multidisciplinary team?

Position

(Post-doctoral) Researcher

Department(s)

Chemical Engineering and Chemistry

FTE

1,0

Date off

15/08/2021

Reference number

V37.5121

Job description

A remarkable class of biopolymers known as ice-binding proteins alleviate the risk of freeze injury throughout the Kingdoms of Life by keeping the nucleation and growth of ice crystals in check. Yet, the application potential of analogues of ice-binding proteins as cryoprotectants has remained underexploited. This is because we are yet to unravel and utilize the structure-function relations, which govern their activity as inhibitors of ice recrystallization and promoters of ice nucleation at the single-molecule level in vitro and within a complex biological environment. In this project you will engineer new biosynthetic, ice-binding protein-polymers aiming to modulate independently their ability to inhibit recrystallization, control nucleation, and shape ice crystals. You will design and prepare various series of these novel ice-binders to elucidate how to customize activity. You will study their properties, assembly in solution, and activity. You will collaborate with other group members to elucidate the mechanisms underpinning activity through single molecule experiments of ice-binding as well as the application potential in cardiac regenerative medicine.

Job requirements
  • PhD in biophysics. Experience with (computer-aided) protein engineering, protein biophysics, and (polarized) optical microscopy; knowledge of crystallization and microfluidics is preferred.
  • Ability to conduct high quality academic research, demonstrated by an outstanding PhD thesis and publications in peer-reviewed journals.
  • Strong motivation to do excellent, original, fundamental research.
  • Excellent mastering of the English language, good communication and leadership skills. Note that there is no Dutch language requirement.
  • Independent and goal-oriented scientist. Team player and able to work in a dynamic, interdisciplinary, and international context.
  • Conditions of employment
  • A meaningful job in a dynamic and ambitious university with the possibility to present your work at international conferences.
  • A full-time employment for 1+1 years.
  • You will have free access to high-quality training programs for research, valorization and professional development
  • A gross monthly salary and benefits in accordance with the Collective Labor Agreement for Dutch Universities.
  • A broad package of fringe benefits (including an excellent technical infrastructure, moving expenses, and savings schemes).
  • Family-friendly initiatives are in place, such as an international spouse program, and excellent on-campus children day care and sports facilities.
  • Information and application

    For further information on this vacancy please contact

    Prof. Dr. Ir. Ilja Voets, i.voetsattue.nl or +31 40 247 5303

    For information about terms of employment, please contact Leo van Houten, l.v.houtenattue.nl or +31 40 247 8269

    Please visit www. tue.nl/jobs to find out more about working at TU/e!

    Application

    We invite you to submit a complete application by using the 'apply now'-button on this page. The application should include a:

  • Cover letter in which you describe your motivation and qualifications for the position.
  • Curriculum vitae, including a list of your publications and the contact information of three references.
  • A letter of recommendation from one or more of your references.
  • List of five self-selected ‘best publications'.
  • We do not respond to applications that are sent to us in a different way.

    Please keep in mind you can upload only 5 documents up to 2 MB each. If necessary, please combine files.

    We look forward to your application and will screen it as soon as we have received it. Screening will continue until the position has been filled.

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