Research Field: Biological sciences › Other
Researcher Profile: First Stage Researcher (R1)
Application Deadline: 01/10/2021 23:00 - Europe/London
Location: Portugal › LISBON
Type Of Contract: Temporary
Job Status: Full-time
Hours Per Week: 40
Reference Number: IMM/BIPD/18-2021
Work Plan and Objectives: The successful candidate will conduct a workplan
intended at elucidating the role of different subpopulations of neutrophils in
human psoriasis, a frequent (2-3% prevalence worldwide) IL-17 and
IL-23-driven autoimmune disorder affecting the skin. Neutrophils are short-
lived myeloid cells that have recently emerged as playing a central role in
psoriasis, namely through their participation in IL-17- and IL-23-dependent
pathways. Moreover, neutrophils are known to comprise biologically diverse
subpopulations with different inflammatory potential whose role in the
pathogenesis of psoriasis remains to be clarified. This research aims at
testing whether, in patients suffering from plaque-type psoriasis, blockade of
the IL-17 pathway with therapeutic antibodies affects blood and skin-
infiltrating neutrophils and their functions. Controls are provided by
patients not undergoing therapy with biologicals. In neutrophils, the
activation of the IL-17 and the IL-23-dependent pathways will be assessed
(protein and mRNA level) as well as the production of ROS (reactive oxygen
species) and NETs (Neutrophil Extracellular Traps), and respiratory burst.
To do so, high-end methodologies for gene expression analysis will be
performed at both single cell and cell population levels on laser micro-
dissected skin-infiltrating neutrophils (skin biopsies) and flow-sorted
blood neutrophils. This study shall provide insight on the response of
different subpopulations of neutrophils to IL-17 pathway blockade, and deliver
clinically useful correlates of therapeutic response.
Predicted start date, duration and renewal conditions: The fellowship contract
is predicted to start in November 2021, for a period of 12 (twelve) months
on an exclusive basis, eventually renewable until the maximum stipulated in
applicable regulations, not exceeding the eligibility period of the project
(predicted to end on 31/10/2024).
Application documents: - Motivation Letter; - Detailed CV; PhD certificate; -
Contacts of two references.
The non-compliance with these requirements determines the immediate
rejection of the application.
In case the applicant does not have yet the required degree certificate, a
declaration of honor stating the conclusion of the necessary qualifications
for the purposes of this process will be accepted and must be sent by the end
date of the call.
Deadlines and application process: The call will be open from 13th September
until 1st October 2021.
Applications should be addressed to Human resources through the email imm-
firstname.lastname@example.org, by indicating the reference of the fellowship. The
non-compliance with these requirements determines the immediate rejection of
Fellowship contracting: The Fellowship is granted through the signature of a
contract between iMM and the selected fellow and after the fellow send the
following mandatory documents: copy of identification document (in case of
non-European citizens is mandatory the work visa / valid resident permit) and
document proving the required academic degree.
The fellow will benefit from a monthly stipend in the amount of 1755€ in
accordance with the applicable regulation. The amount will be paid by wire
transfer at the end of each month. The fellow will also benefit from a
personal accident insurance to execute the proposed research activities as
well as the right to Social Security through Voluntary Social Insurance
regimen, if wanted, under the terms of Código dos Regimes Contributivos do
Sistema Previdencial de Segurança Social, and the contributions costs will be
supported by the research project.
Any National, foreign and stateless candidate(s) can apply.
Jury evaluation and selection: Paulo Filipe (CHLN/FMUL/IMM), João Ferreira
(FMUL/IMM) and Miguel Alpalhão (IMM).
Selection methods: Curricular evaluation (50%), Interview (50%).
Notification of results: The evaluation results will be announced within 90
days after the termination of the applications submission deadline, by writing
and publishing a jury meeting minute at iMM website at
https: // imm.medicina.ulisboa.pt/jobs/#results with all process of
recruitment, evaluation and selection including a list of all excluded and
admitted candidates and for these last ones, their classification. All
admitted candidates will be notified by email.
Selection reserve list: A reserve selection list will be created for a period
of 2 months.
Preliminary Hearing and Final Decision Deadline: Pursuant to article 121 of
the Administrative Procedure Code, after notified, all candidates have 10
working days to respond. Panel's final decisions are pronounced within a
period of 90 days, from application deadline.
For each Fellowship period an Activity Report must be prepared by the fellow
as well as the Report by the supervisor.
Web site for additional job details
https: // imm.medicina.ulisboa.pt/pt-pt/emprego/#jobs
REQUIRED EDUCATION LEVEL
Biological sciences: PhD or equivalent
Applicants must hold the following requirements:
- PhD degree holder in Cell/Molecular Biology, Immunology, Biochemistry or
related areas, recently obtained;
- Experience in basic cell and molecular biology technologies;
- Knowledge and experience in immunology (Desirable);
- Fluency in English language.
Department: Dermatology, Skin Biology and Pathology Lab
Organisation Type: Research Laboratory
Website: https: // imm.medicina.ulisboa.pt
Postal Code: 1649-028
Street: Av. Prof. Egas Moniz, Ed. Egas Moniz