Postdoctoral Research Fellowship, Ref. Imm/Bipd/18-2021

Universities and Institutes of Portugal

Portugal

October 1, 2021

Description

  • Organisation/Company: IMM
  • Research Field: Biological sciences › Other
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 01/10/2021 23:00 - Europe/London
  • Location: Portugal › LISBON
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 40
  • Reference Number: IMM/BIPD/18-2021
  • Work Plan and Objectives: The successful candidate will conduct a workplan intended at elucidating the role of different subpopulations of neutrophils in human psoriasis, a frequent (2-3% prevalence worldwide) IL-17 and IL-23-driven autoimmune disorder affecting the skin. Neutrophils are short- lived myeloid cells that have recently emerged as playing a central role in psoriasis, namely through their participation in IL-17- and IL-23-dependent pathways. Moreover, neutrophils are known to comprise biologically diverse subpopulations with different inflammatory potential whose role in the pathogenesis of psoriasis remains to be clarified. This research aims at testing whether, in patients suffering from plaque-type psoriasis, blockade of the IL-17 pathway with therapeutic antibodies affects blood and skin- infiltrating neutrophils and their functions. Controls are provided by patients not undergoing therapy with biologicals. In neutrophils, the activation of the IL-17 and the IL-23-dependent pathways will be assessed (protein and mRNA level) as well as the production of ROS (reactive oxygen species) and NETs (Neutrophil Extracellular Traps), and respiratory burst. To do so, high-end methodologies for gene expression analysis will be performed at both single cell and cell population levels on laser micro- dissected skin-infiltrating neutrophils (skin biopsies) and flow-sorted blood neutrophils. This study shall provide insight on the response of different subpopulations of neutrophils to IL-17 pathway blockade, and deliver clinically useful correlates of therapeutic response.

    Predicted start date, duration and renewal conditions: The fellowship contract is predicted to start in November 2021, for a period of 12 (twelve) months on an exclusive basis, eventually renewable until the maximum stipulated in applicable regulations, not exceeding the eligibility period of the project (predicted to end on 31/10/2024).

    Application documents: - Motivation Letter; - Detailed CV; PhD certificate; - Contacts of two references.

    The non-compliance with these requirements determines the immediate rejection of the application.

    In case the applicant does not have yet the required degree certificate, a declaration of honor stating the conclusion of the necessary qualifications for the purposes of this process will be accepted and must be sent by the end date of the call.

    Deadlines and application process: The call will be open from 13th September until 1st October 2021.

    Applications should be addressed to Human resources through the email imm- hr@medicina.ulisboa.pt, by indicating the reference of the fellowship. The non-compliance with these requirements determines the immediate rejection of the application.

    Fellowship contracting: The Fellowship is granted through the signature of a contract between iMM and the selected fellow and after the fellow send the following mandatory documents: copy of identification document (in case of non-European citizens is mandatory the work visa / valid resident permit) and document proving the required academic degree.

    Benefits

    The fellow will benefit from a monthly stipend in the amount of 1755€ in accordance with the applicable regulation. The amount will be paid by wire transfer at the end of each month. The fellow will also benefit from a personal accident insurance to execute the proposed research activities as well as the right to Social Security through Voluntary Social Insurance regimen, if wanted, under the terms of Código dos Regimes Contributivos do Sistema Previdencial de Segurança Social, and the contributions costs will be supported by the research project.

    Eligibility criteria

    Any National, foreign and stateless candidate(s) can apply.

    Selection process

    Jury evaluation and selection: Paulo Filipe (CHLN/FMUL/IMM), João Ferreira (FMUL/IMM) and Miguel Alpalhão (IMM).

    Selection methods: Curricular evaluation (50%), Interview (50%).

    Notification of results: The evaluation results will be announced within 90 days after the termination of the applications submission deadline, by writing and publishing a jury meeting minute at iMM website at https: // imm.medicina.ulisboa.pt/jobs/#results with all process of recruitment, evaluation and selection including a list of all excluded and admitted candidates and for these last ones, their classification. All admitted candidates will be notified by email.

    Selection reserve list: A reserve selection list will be created for a period of 2 months.

    Preliminary Hearing and Final Decision Deadline: Pursuant to article 121 of the Administrative Procedure Code, after notified, all candidates have 10 working days to respond. Panel's final decisions are pronounced within a period of 90 days, from application deadline.

    Additional comments

    For each Fellowship period an Activity Report must be prepared by the fellow as well as the Report by the supervisor.

    Web site for additional job details

    https: // imm.medicina.ulisboa.pt/pt-pt/emprego/#jobs

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: PhD or equivalent

    Skills/Qualifications

    Applicants must hold the following requirements:

    - PhD degree holder in Cell/Molecular Biology, Immunology, Biochemistry or related areas, recently obtained;

    - Experience in basic cell and molecular biology technologies;

    - Knowledge and experience in immunology (Desirable);

    - Fluency in English language.

    Contact Information
  • Organisation/Company: IMM
  • Department: Dermatology, Skin Biology and Pathology Lab
  • Organisation Type: Research Laboratory
  • Website: https: // imm.medicina.ulisboa.pt
  • E-Mail: imm-hr@medicina.ulisboa.pt
  • Country: Portugal
  • City: Lisboa
  • Postal Code: 1649-028
  • Street: Av. Prof. Egas Moniz, Ed. Egas Moniz
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