Postdoctoral Research Fellow Position Available In The Molecular And Cellular Plasticity In...

Universities and Institutes of France

France

August 6, 2021

Description

  • Organisation/Company: INSERM U1166
  • Research Field: Biological sciences › Biology
  • Researcher Profile: Established Researcher (R3) Recognised Researcher (R2)
  • Application Deadline: 06/08/2021 23:00 - Europe/Athens
  • Location: France › PARIS
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 37,40
  • Offer Starting Date: 01/10/2021
  • Eu Research Framework Programme: H2020
  • Is The Job Related To Staff Position Within A Research Infrastructure?: Yes
  • The UMRS 1166 – ICAN (Research unit on cardiovascular and metabolic diseases) is a dynamic research center located in Paris center that comprises internationally recognized groups focusing on cardiovascular and metabolic diseases. We seek to hire a highly motivated postdoctoral fellow to investigate the biology of the atrial cardiomyopathy and atrial fibrillation in the team led by Elise Balse at the UMRS 1166-ICAN, under the direction of Pr Stéphane Hatem.

    The post doctorate will work with research assistants and scientists to decipher the mechanism underlying the expansion of the adipose tissue in the atrial myocardium and it replacement by fibrosis. The project will examine the role played by resident progenitor cells in the expansion of the adipose tissue and of inflammation in fibrosis. The project will be conducted using both human tissue and animal models including transgenic mice to trace the fate of epicardial progenitors. The candidate should have a solid training and strong knowledge in molecular and cellular biology cellular biology. Previous experiences in single cell RNA sequencing will be appreciated. Experience in cardiac cell isolation and manipulation would also be appreciated. Strong writing and oral communication skills will be needed. The candidate should have demonstrated innovation, initiative, problem-solving attitude, and ability to work well both independently and as a member of a team. Working languages will be English and French.

    The position, opened for two years (with a possibility of one-year renewal), offers creative and stimulating working conditions in dynamic and international research environment. Salary will be in accordance with the University scale, depending on experience. Application deadline is October 2021 (but will remain open until suitable candidates are found).

    Benefits

    The UMRS 1166 – ICAN (Research unit on cardiovascular and metabolic diseases) is a dynamic research center located in Paris center that comprises internationally recognized groups focusing on cardiovascular and metabolic diseases. We seek to hire a highly motivated postdoctoral fellow to investigate the biology of the atrial cardiomyopathy and atrial fibrillation in the team led by Elise Balse at the UMRS 1166-ICAN, under the direction of Pr Stéphane Hatem.

    Eligibility criteria

    The candidate should have a solid training and strong knowledge in molecular and cellular biology cellular biology. Previous experiences in single cell RNA sequencing will be appreciated. Experience in cardiac cell isolation and manipulation would also be appreciated. Strong writing and oral communication skills will be needed. The candidate should have demonstrated innovation, initiative, problem-solving attitude, and ability to work well both independently and as a member of a team. Working languages will be English and French.

    Selection process

    CV, list of publications, short description of previous research projects and experience and contact information for (at least) two referees should be sent by email to : stephane.hatem@sorbonne-universite.fr

    Additional comments

    Publications related to the project:

  • Venteclef N, Guglielmi V, Balse E, Gaborit B, Cotillard A, Atassi F, Amour J, Leprince P, Dutour A, Clément K, Hatem SN. Human Epicardial Adipose Tissue Induces Fibrosis of the Atrial Myocardium through the Secretion of Adipo-fibrokines. Eur Heart J. 2015 Apr 1;36(13):795-805a. doi: 10
  • Haemers P, Hamdi H, Guedj K, Suffee N Farahmand P; Popovic N,Claus P, leprince P, Nicoletti A, Jalife J, Wolke C, Lendeckel U, Jaïs P, Willems R, Hatem SN. Atrial Fibrillation is associated with the fibrotic remodeling of adipose tissue in the subepicardium of adipose tissue of human and sheep atria. Eur Heart J. 2017 Nov 26. pii: ehv625
  • Jumeau C, Rupin A, Chieng-Yane P, Mougenot N, Zahr N, David-Dufilho M, Hatem SN. Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats. JACC Basic Transl Sci. 2016 Jul 13;1(5):328-339.
  • Suffee N, Moore-Morris T, Farahmand P, Catherine Rücker-Martin4, Gilles Dilanian1, Magali Fradet5, Daigo Sawaki6, Geneviève Derumeaux6, Pascal LePrince1,3, Karine Clément1,5, Isabelle Dugail1, Michel Puceat2, Stéphane N. Hatem. Atrial natriuretic peptide regulates adipose tissue accumulation in adult atria. Proc Natl Acad Sci U S A, 2017 Jan 31;114(5):E771-E780.
  • Offer Requirements Skills/Qualifications

    The candidate should have a solid training and strong knowledge in molecular and cellular biology cellular biology. Previous experiences in single cell RNA sequencing will be appreciated. Experience in cardiac cell isolation and manipulation would also be appreciated. Strong writing and oral communication skills will be needed. The candidate should have demonstrated innovation, initiative, problem-solving attitude, and ability to work well both independently and as a member of a team. Working languages will be English and French.

    Contact Information
  • Organisation/Company: INSERM U1166
  • Organisation Type: Research Laboratory
  • Website: https: // recherche-cardiovasculaire-metabolique.fr/
  • E-Mail: stephane.hatem@sorbonne-universite.fr
  • Country: France
  • City: Paris
  • Postal Code: 75013
  • Street: 91 Boulevard de l'hôpital
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