Postdoctoral Research Associate

University of Oxford
August 12, 2024
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Postdoctoral Research Associate

Department of Paediatrics, Institute of Developmental & Regenerative Medicine IDRM, Old Road Campus, Oxford

About the role

A large, international, collaborative Research Centre, focused on using genomic methodologies to develop therapies for rare genetic disorders, has recently received substantial funding. A position is available for a highly motivated Postdoctoral Research Associate with expertise in bioinformatics to join the research groups led by Prof Stephan Sanders and A/Prof Carlo Rinaldi at the University of Oxford. These two groups focus on genetic causes of neurological and neurodevelopmental disorders with the goal of developing cutting-edge genetic therapies for these disorders with bench-to-bedside programs that include bioinformatics, functional genomics, therapeutic development, stem cell modelling, and clinical trials. Both labs have clinical expertise and work closely with families and individuals affected by rare genetic disorders.

Non-coding regulatory elements play a pivotal role in governing gene expression, and their disruption is increasingly recognized as a therapeutic target for disorders (e.g., genome editing in sickle cell disease). This is an exciting opportunity for a postdoctoral scientist to help lead a project focusing on interrogating regulatory element function in the context of neurological and neurodevelopmental disorders, with the goal of precisely modulating activity to offer treatment opportunities for these disorders via modulating gene expression. The project will apply a wide variety of bioinformatic and statistical techniques to bulk and single nuclei functional genomic data generated by our teams (e.g., ChIP-seq, RNA-seq, ATAC-seq). Analyses will be performed on collaborative cloud computing environments using the extensive computing infrastructure and programmer support provided by the Sanders Lab informatics team.

The successful candidate will be involved with all aspects of the data processing analysis including experimental design, analysis, interpretation, and dissemination. The post holder will work at the newly built Institute of Developmental and Regenerative Medicine (IDRM) at the Old Road/Churchill Campus of the University of Oxford in the adjacent laboratories of Prof Stephan Sanders and A/Prof Carlo Rinaldi. She/he will be supported by their existing collaborative teams that include data managers, bioinformatic postdocs, PhD candidates, and research assistants.

Career Development: The post holder will be able to receive training in collaborating labs in order to benefit from interaction with researchers in diverse environments. She/he will be encouraged to attend training and research skill courses provided by the University of Oxford. There will be opportunities for contributing to and leading grant applications, if appropriate, as well as being encouraged to submit work for presentation at national and international conferences. In addition, experience gained by supervision and mentoring of junior members in the lab will be useful for career development. The successful applicant will be expected to provide guidance and assistance to other researchers in the group and students, help in the preparation of scientific publications, and represent the group at public engagement events.

Diversity is a core value of our university, department, institute, and research groups. We encourage applications from trainees of all backgrounds.

About the applicant

This is a highly collaborative position, so excellent communication and interpersonal skills are essential. Applicants will need to hold a PhD or equivalent in Genetics, Biostatistics, Computational Biology, or a related subject. She/he will need to have demonstrated proficiency in computer programming (Python or R preferred), high-performance computing environments, human genetics, biostatistics, and/or bioinformatics leading to impactful publications and experiencing in analysing ChIP-seq, RNA-seq, or ATAC-seq data. We are looking for an individual who is passionate about advancing research into genetic disorders to help those affected.

Application Process

You will be required to upload a CV and Supporting Statement as part of your online application. We recommend that the supporting statement is formatted as a one or two page letter addressed to ‘Drs. Sanders and Rinaldi' that describes: 1) how your skills and experience meet each of the selection criteria for the post, 2) reason for interest in this field of research, and 3) explanations for career breaks (e.g., time out to care for dependents), dramatic shifts in field of research, substantive prior postdoctoral work, or similar. Click here for information and advice on writing an effective Supporting Statement.

This role meets the criteria for a UK Skilled Worker visa.

To discuss the post in more detail, please contact Carlo Rinaldi at [email protected] and/or Stephan Sanders at [email protected] .

Only online applications received before 12.00 midday on 12th August 2024 will be considered. Interviews will be held as soon as possible thereafter.

Contact Person : Associate Prof. Carlo Rinaldi and Prof. Stephan Sanders Vacancy ID : 173988 Contact Phone : Closing Date & Time : 12-Aug-2024 12:00 Pay Scale : STANDARD GRADE 7 Contact Email : [email protected] Salary (£) : 36,024 - 44,263 with a discretionary range to 48,350 per annum (pro-rata)

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