Postdoctoral Research Associate

University of Georgia

United States

December 22, 2021

Description

Posting Details Posting Number G/R04832P

Working Title Postdoctoral Research Associate Department VPR-Ctr for Molecular Medicine About the University of Georgia

The University of Georgia (UGA), a land-grant and sea-grant university with statewide commitments and responsibilities, is the state's oldest, most comprehensive, and most diversified institution of higher education (https: // www. uga.edu/). UGA is currently ranked among the top 15 public universities in U.S. News & World Report. The University's main campus is located in Athens, approximately 65 miles northeast of Atlanta, with extended campuses in Atlanta, Griffin, Gwinnett, and Tifton. UGA was founded in 1785 by the Georgia General Assembly as the first state-chartered University in the country. UGA employs approximately 1,800 full-time instructional faculty and more than 7,700 full-time staff. The University's enrollment exceeds 39,000 students including over 30,000 undergraduates and over 9,000 graduate and professional students. Academic programs reside in 18 schools and colleges, as well as a medical partnership with Augusta University housed on the UGA Health Sciences Campus in Athens.

About the College/Unit/Department College/Unit/Department website Employment Type Employee Additional Schedule Information Advertised Salary Anticipated Start Date 08/16/2019 Posting Date 08/06/2019 Closing Date Open Until Filled Yes Special Instructions to Applicants Location of Vacancy Athens Area EOO Statement

The University of Georgia is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, ethnicity, age, genetic information, disability, gender identity, sexual orientation or protected veteran status.

UGA Statement

The University of Georgia is a Federal Contractor as defined by Presidential Executive Order 14042 and subject to the requirement that Federal Contractors must ensure that all covered employees, including those working remotely, are fully vaccinated by January 4, 2022. You may be required to show proof of your fully vaccinated status at the time of your start date, or have received a medical or religious exemption from the fully vaccinated requirement at the time of your start date. For more information regarding the Federal Contractor fully vaccinated employment requirement please visit https: // coronavirus.uga.edu/executive-order/ or call (706) 542-2222.

Duties/Responsibilities

Please approximate the percentage of time spent on each task (out of 100%) during a typical work week. List these tasks in order of importance, with the most critical task coming first. Do not list more than 6 entries – do not go below 5% time per assigned duty.

Duties/Responsibilities

Determine the chromatin changes in ESC lines depleted of Dppa2/4 and the key interacting partners using ChIP-Seq

Percentage of time 30 Duties/Responsibilities

Inactivate key Dppa2/4 interacting partners in ESCs and test the ability of these KO cells to form germ layers

Percentage of time 30 Duties/Responsibilities

Generate Dppa2/4 knockout and overexpression ES cell lines and charactere their differentiation capacity using single-cell RNA-seq

Percentage of time 20 Duties/Responsibilities

Prepare oral or written reports, write manuscripts, and maintain records of the research carried out as part of this project

Percentage of time 10 Duties/Responsibilities

Purify Dppa2/4 associated proteins using immunoprecipitation and mass- spectrometry

Percentage of time 10

Position Details Classification Title Post-Doctoral Associate AD

FLSA Exempt UGA Job Code Job Family FTE 1.00 Minimum Qualifications Position Summary

The postdoctoral research associate will work on a new project to elucidate the mechanism that maintains permissive chromatin in embryonic stem cells which is required for stem cell self-renewal and differentiation. The Ivanova lab has recently identified two novel proteins, Dppa2 and Dppa4, that play a key role in resetting the chromatin to a pluripotent configuration during cellular reprogramming (PMID: 30146411). Our new unpublished data indicate that Dppa2/4 are also required during stem cell differentiation to ensure correct execution of lineage-specific programs. The candidate will be leading efforts to define the mechanism of action for these two genes using genetic, biochemical and bioinformatics approaches including human embryonic stem cell culture, CRISPR/Cas9 genome editing, single-cell RNA-Seq, ChIP-Seq, mass- spectrometry and immunofluorescence studies. The candidate will be expected to prepare oral and written reports, write manuscripts and maintain detailed records of the research. The candidate will travel to one relevant scientific meeting per year to present the results to a broader stem cell research community.

Relevant/Preferred Education, Experience, Licensure, Certification in Position

Ph.D. in genetics, biochemistry, biology or a related discipline.

Knowledge, Skills, Abilities and/or Competencies

Preference will be given to candidates who have hands-on experience with human embryonic stem cell culture, genome engineering, genomics and/or purification of protein complexes. Strong communication skills and fluency in written and spoken English are essential as is the ability to work in a collaborative scientific environment.

Physical Demands

Normal for laboratory work

Is this a Position of Trust? Does this position have operation, access, or control of financial resources? No Does this position require a P-Card? No Is having a P-Card an essential function of this position? No Is driving a requirement of this position? Does this position have direct interaction or care of children under the age of 18 or direct patient care? No Does this position have Security Access (e.g., public safety, IT security, personnel records, patient records, or access to chemicals and medications) No

Contact Information Contact Details

Recruitment Contact Name Recruitment Contact Email Recruitment Contact Phone

Posting Specific Questions

Required fields are indicated with an asterisk ().

Applicant Documents

Required Documents

  • Resume/CV
  • Optional Documents

  • Cover Letter
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