Postdoctoral Research Associate in the evolution of epigenetic gene regulation
Department of Biochemistry, South Parks Road, Oxford
Grade 7: £33,309 - £40,927 per annum
We are seeking to appoint a Postdoctoral Research Associate to work in the
laboratory of Associate Prof Peter Sarkies on the evolution of epigenetic
mechanisms in cancer. This project builds on the discovery made by the Sarkies
lab that DNA methyltransferases, key epigenetic regulators conserved across
eukaryotes, have a side reaction that introduces alkylation damage into DNA
(Rosic et al., Nature Genetics, 2018). The enzyme ALKB2 is required to
repair the alkylation damage induced by DNMT off-target activity and thus co-
evolves with DNMTs across eukaryotic species. In this project we aim to
explore the possibility that the toxic effect of DNMT activity might be
responsible for the evolution of reduced methylation levels in cancer (DNA
hypomethylation). Additionally, we will investigate whether the balance
between DNMT and ALKB2 levels affects the sensitivity of cells to DNA damaging
agents, potentially opening up new angles for treating cancer.
Applicants should hold a PhD/DPhil, or be near completion of a PhD/DPhil in a
relevant subject area and possess sufficient specialist knowledge in order to
work within established research programmes. You will have the ability to
manage your own academic research and associated activities and have
experience of contributing to publications and presentations. Experience with
mammalian cell culture and knowledge of epigenetic gene regulatory mechanisms
is essential. You will have the ability to contribute ideas for new research
projects and research income generation, together with excellent communication
skills including the ability to write for publication, present research
proposals and results and representing the research group at meetings.
This full-time fixed-term post is funded by Worldwide Cancer Research for up
to 2.5 years in the first instance and is based at the Department of
Biochemistry, South Parks Road, Oxford.
This position is graded on the University's Grade 7 scale. The actual starting
salary offered will be based on qualifications and relevant skills acquired
and will also be determined by the funding available.
To apply for this role and for further details including the job description
and selection criteria, please see the document below. You will be required to
upload a supporting statement and CV as part of your application.
The closing date for applications is 12.00 noon on Friday 7th January
2022 , with interviews for shortlisted candidates to be held as soon as
Contact Person : HR Officer Vacancy ID : 154718
Contact Phone : 01865 613204 Closing Date & Time : 07-Jan-2022 12:00
Contact Email : firstname.lastname@example.org