Postdoctoral Research Associate in the evolution of epigenetic gene regulation in cancer

University of Oxford

United Kingdom

January 7, 2022


Postdoctoral Research Associate in the evolution of epigenetic gene regulation in cancer

Department of Biochemistry, South Parks Road, Oxford Grade 7: £33,309 - £40,927 per annum

We are seeking to appoint a Postdoctoral Research Associate to work in the laboratory of Associate Prof Peter Sarkies on the evolution of epigenetic mechanisms in cancer. This project builds on the discovery made by the Sarkies lab that DNA methyltransferases, key epigenetic regulators conserved across eukaryotes, have a side reaction that introduces alkylation damage into DNA (Rosic et al., Nature Genetics, 2018). The enzyme ALKB2 is required to repair the alkylation damage induced by DNMT off-target activity and thus co- evolves with DNMTs across eukaryotic species. In this project we aim to explore the possibility that the toxic effect of DNMT activity might be responsible for the evolution of reduced methylation levels in cancer (DNA hypomethylation). Additionally, we will investigate whether the balance between DNMT and ALKB2 levels affects the sensitivity of cells to DNA damaging agents, potentially opening up new angles for treating cancer.

Applicants should hold a PhD/DPhil, or be near completion of a PhD/DPhil in a relevant subject area and possess sufficient specialist knowledge in order to work within established research programmes. You will have the ability to manage your own academic research and associated activities and have experience of contributing to publications and presentations. Experience with mammalian cell culture and knowledge of epigenetic gene regulatory mechanisms is essential. You will have the ability to contribute ideas for new research projects and research income generation, together with excellent communication skills including the ability to write for publication, present research proposals and results and representing the research group at meetings.

This full-time fixed-term post is funded by Worldwide Cancer Research for up to 2.5 years in the first instance and is based at the Department of Biochemistry, South Parks Road, Oxford.

This position is graded on the University's Grade 7 scale. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available.

To apply for this role and for further details including the job description and selection criteria, please see the document below. You will be required to upload a supporting statement and CV as part of your application.

The closing date for applications is 12.00 noon on Friday 7th January 2022 , with interviews for shortlisted candidates to be held as soon as possible thereafter.

Contact Person : HR Officer Vacancy ID : 154718 Contact Phone : 01865 613204 Closing Date & Time : 07-Jan-2022 12:00 Contact Email :

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The University of Oxford is the oldest university in the English-speaking world, and is actually so ancient that its founding date is unknown – though it is thought that teaching took place there as early as the 11th century. It’s...