Postdoctoral Research Associate in Structure-informed studies of the
extracellular region of the human notch receptor in health & disease
Department of Biochemistry, South Parks Road, Oxford
Grade 7: £32,817 - £40,322 p.a.
We are seeking to appoint a Postdoctoral Research Associate to join Prof Penny
Handford's group working on Notch signalling in health and disease. The
project aims to investigate structure/function relationships in Notch
extracellular domains and determine how intra- and inter-molecular
interactions may regulate receptor activity. You will use a combination of
molecular and cell-based assays to probe the effects of structure-informed
mutations on Notch activation.
Applicants should possess a PhD/DPhil, or be near completion of a PhD/DPhil in
Biochemistry, Cell Biology or a related area, with experience of working in
the area of molecular and cellular characterisation of mammalian cell
surface/extracellular proteins. You will be familiar with mammalian cell
culture and creation of stable and/or CRISPR/Cas9-edited cell lines, FACS, as
well as recombinant protein expression (prokaryotic and eukaryotic systems)
and chromatography methods and have applied these methods in your research.
Knowledge of biophysical and biochemical analytical techniques such as SPR,
mass spectrometry, NMR, ELISA-type plate assays would also be useful.
Excellent written and oral communication skills are required, as you will need
to keep detailed laboratory records to meet publication standards, as well as
give verbal updates on research progress. You will be required to demonstrate
considerable self-motivation, independence, competence and success in your
thesis and/or postdoctoral work, and have the ability to work collaboratively
and supportively in a laboratory environment, as well as contributing to
This full time fixed term post is funded by the MRC for up to 3 years in the
first instance and is based at the Department of Biochemistry, South Parks
Road, Oxford, OX1 3QU.
This position is graded on the University's Grade 7 scale. The actual starting
salary offered will be based on qualifications and relevant skills acquired
and will also be determined by the funding available.
To apply for this role and for further details including the job description
and selection criteria, please see the document below. You will be required to
upload a supporting statement and CV as part of your application.
The closing date for applications is 12.00 noon on Monday 5th July
2021 , with interviews for shortlisted candidates to be held as soon as
Contact Person : HR Officer Vacancy ID : 151502
Contact Phone : 01865 613204 Closing Date & Time : 05-Jul-2021 12:00
Contact Email : email@example.com