Postdoctoral Position In Single Cell Analysis Of Cell Differentiation In Vivo (1.0 Fte)

Utrecht University

Netherlands

October 31, 2021

Description

Postdoctoral position in single cell analysis of cell differentiation in

vivo (1.0 FTE)

Job description

The Van den Heuvel lab invites applications for a postdoctoral research position in Developmental Biology. The focus of the project will be to reveal the regulatory logic of cellular decision making in the context of animal development. Specifically, we seek to better understand how precursor cells commit to a specialized cellular fate, and how this is coordinated with a permanent arrest of cell division. To address these questions, we will perform detailed quantitative analyses of native cells during their differentiation trajectory in the round worm Caenorhabditis elegans ( C. elegans ), in combination with sophisticated genetic manipulation. This project will incorporate the latest technologies in transcriptome, epigenome, and proteome analysis, and will be carried out in close collaboration with specialists in computational modeling (Ten Tusscher lab, Utrecht University), single-cell analysis (Korswagen and Van Oudenaarden labs, Hubrecht Institute), and proteomics techniques (Vermeulen lab, Radboud University Nijmegen).

Qualifications

We are looking for a curious and ambitious junior scientist who:

  • holds a PhD degree in biology, biomedical sciences or a related field;
  • has a strong interest in molecular biology;
  • has previous experience with independent research, and preferably worked with genetic model organisms, advanced microscopy, and/or bioinformatic data analysis;
  • has been trained in scientific writing, communication and presentation in English;
  • has the motivation to work in an ambitious, multidisciplinary and international research team.
  • Offer

  • a full-time position for two years;
  • embedding in a great team of top Life Sciences Researchers;
  • depending on previous qualifications and experience, a gross salary ranging between €2,836 and €5,211 per month (scale 10/11 of the Collective Labour Agreement of Dutch Universities) for a full-time employment;
  • 8% holiday bonus and 8.3% end-of-year bonus;
  • a pension scheme, partially paid parental leave, and flexible employment conditions (based on the Collective Labour Agreement Dutch Universities).
  • About the organization

    Research in the Developmental Biology Division makes use of a multidisciplinary strategy in genetic animal model systems ( C. elegans , zebrafish, organoids) to acquire a deeper fundamental understanding of the processes that determine development and health. Three teams that use the C. elegans model work closely together and share experience in C. elegans genetics and biology, as well as technologies (latest CRISPR knock- in/knockout strategies, live imaging, super-resolution microscopy) on a daily basis. In addition, there are frequent interactions and joint lab meetings with the neighbouring labs (Cell Biology, Neurobiology, Biophysics), the nearby Theoretical Biology and Bioinformatics groups. These groups and a newly started Genome Biology & Epigenetics group form part of the Institute of Biodynamics and Biocomplexity (IBB).

    Additional information

    If you have any questions about this position, please contact Sander van den Heuvel, via S.J.L.vandenHeuvel@uu.nl. Do you have a question about the application procedure? Please send an email to science.recruitment@uu.nl.

    Everyone deserves to feel at home at our university. We welcome employees with a wide variety of backgrounds and perspectives. If you have the expertise and experience to excel in this role, please respond via the “Apply” button!

    Please enclose:

  • a one-page cover letter describing the reasons behind your interest in the position;
  • a curriculum vitae;
  • name, telephone number, and email address of three references.
  • The application deadline is 31/10/2021