Postdoctoral Position In Protein Design In The Hebrew University Of Jerusalem

Universities and Institutes of Israel

Israel

October 1, 2022

Description

  • Organisation/Company: The Hebrew University of Jerusalem
  • Research Field: Biological sciences › Biological engineering Biological sciences › Biology Chemistry › Biochemistry Physics › Biophysics
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2)
  • Application Deadline: 01/10/2022 00:00 - Europe/Athens
  • Location: Israel › Jerusalem
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 40
  • Offer Starting Date: 01/12/2022
  • Postdoctoral position in Protein Engineering

    If you are an enthusiastic, committed and responsible student with a love for science and if you are looking for an opportunity to develop novel therapeutic proteins to battle cancer, then our team is looking for you. The Shifman lab in the Hebrew University of Jerusalem is an international and interdisciplinary group located at the in the Givat Ram campus of the Hebrew University as part of the Biological Chemistry Department. (https: // openscholar.huji.ac.il/shifmanlab/). We offer a 3-year fully funded postdoctoral position in our lab.

    Project description

    The goal of this project is to engineer high-affinity specific binders to a known oncogene Ras, whose mutations are found in 30% of all human cancers. Such proteins will be constructed starting from a natural human protein that is able not only to inhibit Ras pro-cancer activities and but also exhibits anticancer activity of its own. Furthermore, the protein will be engineered with capabilities to penetrate tumor environment and to enter cancer cells, where mutated Ras is located. All our projects are interdisciplinary and utilize a combination of structural modeling, experimental directed evolution, biophysical and structural methods for protein characterization, and cellular biology.

    Requirements

    Ph. D. in Biochemistry, Biophysics, Biotechnology or Biology. Experience in molecular biology, protein expression/purification and cellular biology. Computational biology experience is a plus.

    Benefits

    Postdoctoral fellowship is available for the duration of the project (3 years). The fellowship is tax exempt.

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: PhD or equivalent

    Skills/Qualifications

    Experience in molecular biology, protein expression/purification, cell cultures and protein transfection. Computational biology experience is a plus.

    Contact Information
  • Organisation/Company: The Hebrew University of Jerusalem
  • Department: Department of Biological Chemistry - Protein Design and Engineering
  • Organisation Type: Research Laboratory
  • Website: https: // openscholar.huji.ac.il/shifmanlab/
  • E-Mail: jshifman@mail.huji.ac.il
  • Country: Israel
  • City: Jerusalem
  • State/Province: Jerusalem
  • Street: Givat Ram Campus
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