Postdoctoral Position in Neuroproteomics
A three-year postdoctoral position is available on our large Neurobiology
project, DEVELOPNOID, aiming at characterizing neurological diseases using
stem-cell derived brain organoids. Application deadline: 3 February 2022.
Recently, the possibility to differentiate hiPSCs into organized 3D
structures, brain organoids or mini-brains, has provided an efficient tool to
study neuronal development using more mature neurons. Brain organoids are
formed by cellular self-organization of neurons and astrocytes, resulting in
the formation of distinct and interdependent brain regions ex vivo.
Moreover, cerebral organoids developed over extended periods exhibit active
neuronal networks, including the formation of organized and active synapses.
The cellular diversity and 3D organization observed in brain organoids
represent an advantage for modelling complex interactions observed in the
neural microenvironment, including synaptic transmission in synaptosomes.
The project aims at characterizing molecular processes underlying disease
development in developing brain organoids using quantitative proteomics,
modification specific proteomics (PTMomics), metabolomics, bioinformatics
Location of the project:
The project is located in the research group of Professor Martin R. Larsen,
Department of Biochemistry and Molecular Biology at the University of Southern
The Larsen research group is part of the Protein Research Group (PRG) at the
University of Southern Denmark (SDU) in Odense, Denmark. Odense is located
only one hour from the main capital of Denmark, Copenhagen. The PRG was
founded 45 years ago by the recognized protein and biological mass
spectrometry researcher Professor Peter Roepstorff and is internationally
recognized for their contributions within biological mass spectrometry,
proteomics, biomedical research and clinical proteomics. The PRG consist today
of a large research environment with nine individual research groups and more
than 60 scientists, postdocs and students who share laboratory facilities and
research environment. The PRG has a fantastic research environment with many
The PRG has the newest mass spectrometers for biological mass spectrometry
applications including one Orbitrap Fusion Lumos Tribrid, one Orbitrap Eclipse
Tribrid, two Orbitrap Exploris, two Q-Exactive HFs and one TIMS-TOF pro
(Bruker). In addition, the PRG has a large fully equipped protein
chemistry/proteomics laboratory, cell laboratory facilities and bioinformatics
that will be available for the present project.
The Larsen group has for the past 20 years developed a large number of methods
for assessment of PTMs in proteomics, including the Titanium Dioxide method
(Larsen MR et al., Mol. Cell. Proteomics 2005) used by many research groups
worldwide for isolation of phosphorylated peptides for characterization of
signal transduction pathways in mammalian systems. The Larsen group research
focus is centered on investigation of the role of PTMs in system biology and
biomedicine and development of new innovative methods for assessment of PTMs
in biological samples. The Larsen group has a significant amount of national
and international collaborations and is publishing in higher ranging journals.
A successful candidate would have a PhD degree in biochemistry, cell
biology, molecular biology, proteomics or a related field and is highly
motivated and innovative. A candidate with significant experience in stem cell
differentiation, generation of 3D cultures (brain organoids), functional
proteomics, post-translational modification analysis, LC-based mass
spectrometry and bioinformatics is preferable. Excellent communication and
writing skills and an ability to interact socially and scientifically with
other laboratory members and collaborators are essential. Previous postdoc
experience and a strong publication record are also strong merits.
For further information please contact Professor Martin R. Larsen, PhD,
Application, salary etc.
The successful applicant will be employed in accordance with the agreement
between the Ministry of Finance and AC (the Danish Confederation of
Professional Associations). Please check links for more information on salary
The application must include the following:
• A curriculum vitae including information on previous employment.
• A full list of publications stating the scientific publications on which the
applicant wishes to rely.
Shortlisting may be used in the assessment process.
Incomplete applications and applications received after the deadline will
neither be considered nor evaluated.
To qualify you must have passed a PhD or equivalent. Applications will be
assessed by an expert assessor/committee. Applicants will be informed of their
assessment by the university.
The University wishes our staff to reflect the diversity of society and thus
welcomes applications from all qualified candidates regardless of personal
Applications must be submitted electronically using the link "Apply online".
Attached files must be in Adobe PDF or Word format. Each box can only contain
a single file of max. 10 Mb. We strongly recommend that you read How to apply
before you apply.
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