Postdoctoral Position In Immunometabolism / 2 To 3 Years

Universities and Institutes of France

France

October 19, 2022

Description

  • Organisation/Company: INSERM / SORBONNE UNIVERSITY / UMR S 1166 ICAN
  • Research Field: Biological sciences › Biology
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2)
  • Application Deadline: 19/10/2022 21:00 - Europe/Athens
  • Location: France › PARIS
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 37
  • Offer Starting Date: 01/11/2022
  • Is The Job Related To Staff Position Within A Research Infrastructure?: Yes
  • Postdoctoral position in immunometabolism

    We seek to hire a highly motivated candidate to investigate the role of macrophages in metabolic diseases.

    The candidate will work with research assistants and scientists to study how macrophage homeostasis and

    functions are altered in metabolic diseases and how this in turn impact metabolic diseases-associated

    comorbidities. To this aim transgenic mice and pre-clinical mouse models of metabolic diseases will be used

    as well as patient clinical samples.

    Highly motivated scientists with a strong interest in immunometabolism are encouraged to apply. The

    candidate should have a PhD in Life Sciences with a strong knowledge in immunology and/or metabolism as

    well as in molecular and cellular biology. Solid experience with animal experimentation is mandatory.

    Experience in flow cytometry, imaging and molecular biology would also be appreciated. Strong writing and

    oral communication skills will be needed. The candidate should have demonstrated innovation, initiative,

    problem-solving attitude, and ability to work well both independently and as a member of a team. Working

    languages will be French and English.

    The position offers creative and stimulating working conditions in a dynamic and international research

    environment. Salary will be in accordance with the Sorbonne University scale, depending on experience.

    Benefits

    The UMRS 1166 (Research unit on cardiovascular and metabolic diseases) is a dynamic research center

    located in Paris that comprises internationally recognized groups focusing on cardiovascular and metabolic

    diseases (https: // recherche-cardiovasculaire-metabolique.fr/).

    Eligibility criteria

    candidate should have a PhD in Life Sciences with a strong knowledge in immunology and/or metabolism as

    well as in molecular and cellular biology. Solid experience with animal experimentation is mandatory.

    Experience in flow cytometry, imaging and molecular biology would also be appreciated. Strong writing and

    oral communication skills will be needed. The candidate should have demonstrated innovation, initiative,

    problem-solving attitude, and ability to work well both independently and as a member of a team. Working

    languages will be French and English.

    Selection process

    CV, list of publications, short description of previous research projects and experience, and contact

    information for (at least) two referees should be sent by email to: emmanuel-laurent.gautier@inserm.fr

    Additional comments

    The position offers creative and stimulating working conditions in a dynamic and international research

    environment. Salary will be in accordance with the Sorbonne University scale, depending on experience.

    Publications related to the project:

    • Tran S, Baba I, Poupel L, Dussaud S, Moreau M, Gélineau A, Marcelin G, Magréau-Davy E, Ouhachi M, Lesnik P,

    Boissonnas A, Le Goff W, Clausen BE, Yvan-Charvet L, Sennlaub F, Huby T, Gautier EL. Impaired Kupffer cell selfrenewal

    alters the liver response to lipid overload during non-alcoholic steatohepatitis. Immunity. 2020 Sep

    15;53(3):627-640.

    • Huby T, Gautier EL. Immune cell-mediated features of non-alcoholic steatohepatitis. Nat Rev Immunol. 2022

    Jul;22(7):429-443.

    • Marcelin M, Ferreirra A, Liu Y, Atlan M, Aron-Wisnewsky J, Pelloux V, Botbol Y, Ambrosini M, Fradet M, Rouault C,

    Hénégar C, Mutel S, Hulot JS, Poitou C, Torcivia A, Nail Barthelemy R, Bichet JC, Gautier EL, Clement K. PDGFRamediated

    switch to CD9high progenitors controls fibrotic adipose tissue alteration in obesity. Cell Metabolism. 2017

    Mar 7;25(3):673-685.

    • Calippe B, Augustin S, Beguier F, Messance HC, Poupel L, Conart JB, Hu S, Lavalette S, Fauvet A, Rayes J, Levy O,

    Raoul W, Fitting C, Denèfle T, Pickering MC, Harris C, Jorieux S, Sullivan PM, Sahel JA, Karoyan P, Paques M, Sapieha

    P, Guillonneau X, Gautier EL, Sennlaub F. Complement factor H inhibits CD47-mediated resolution of inflammation.

    Immunity. 2017 Feb 21;46(2):261-272

    Offer Requirements Skills/Qualifications

    We seek to hire a highly motivated candidate to investigate the role of macrophages in metabolic diseases.

    The candidate will work with research assistants and scientists to study how macrophage homeostasis and

    functions are altered in metabolic diseases and how this in turn impact metabolic diseases-associated

    comorbidities. To this aim transgenic mice and pre-clinical mouse models of metabolic diseases will be used

    as well as patient clinical samples.

    Highly motivated scientists with a strong interest in immunometabolism are encouraged to apply. The

    candidate should have a PhD in Life Sciences with a strong knowledge in immunology and/or metabolism as

    well as in molecular and cellular biology. Solid experience with animal experimentation is mandatory.

    Experience in flow cytometry, imaging and molecular biology would also be appreciated. Strong writing and

    oral communication skills will be needed. The candidate should have demonstrated innovation, initiative,

    problem-solving attitude, and ability to work well both independently and as a member of a team. Working

    languages will be French and English.

    Specific Requirements

    Working languages will be French and English

    Contact Information
  • Organisation/Company: INSERM / SORBONNE UNIVERSITY / UMR S 1166 ICAN
  • Department: UMR 1166 S ICAN
  • Organisation Type: Public Research Institution
  • Website: https: // recherche-cardiovasculaire-metabolique.fr/?lang=fr
  • E-Mail: emmanuel-laurent.gautier@inserm.fr
  • Country: France
  • City: Paris
  • State/Province: France
  • Postal Code: 75013
  • Street: 91 BD DE L'HOPITAL