We are seeking to recruit a postdoctoral fellow for our newly tenured
laboratory at the Institut Pasteur in Paris.
In the laboratory we study how epigenetics contribute to establishing the
delicate balance that exists between homeostatic responses to commensal
bacteria and virulence processes to pathogenic bacteria. Uncovering the
mechanisms at the root of this balance is crucial for understanding how
invasive infections begin, how asymptomatic colonizations are maintained, and
for potential designing of treatment.
We have integrated histone modifications in phenotypic responses to bacteria
to show important mechanisms exploited by bacteria to subvert the host and
impose an efficient infection 1–4, but have also demonstrated that chromatin
modifiers can be critical regulators of homeostasis and bacterial containment
5. To all of our projects we bring our multidisciplinary expertise, mixing
molecular genetics to microbiology, ensuring a balance between mechanistic
studies and physiology.
The field of bacteria mediated histone modifications is in its infancy and
offers a large margin of discovery in multiple different avenues. We are
currently using Streptococcus pneumoniae as a model bacterium for our
studies. This Gram Positive, on the WHO list of priority pathogens, is
particularly Interestingly for our work, as depending on the strain, it has
the dual nature of being an asymptomatic colonizer as well as causing severe
A variety of different projects both on the host side or the bacterial side
are currently available, for example:
We have shown that the histone demethylase KDM6B is required to control
homeostatic responses 5, but the mechanisms of regulation and action is On
the bacterial side, we know that bacterial factors differentially present
on a colonizing S. pneumoniae strain versus an invasive strain is
driving the KDM6B response, these need to be uncovered.
Our previous work identified H3S10 dephosphorylation as being important
for infection with pneumoniae 1. However, what this modification
provides for infection is unknown.
The applicant must hold a PhD in microbiology, cell biology or some related
field, and have a strong track record of accomplishments.
We are looking for a creative, motivated, rigorous candidate that can work
with and integrate into a dynamic team and an outstanding scientific
environment. Previous experience with cell culture, molecular biology, or
microbiology is a plus.
The working language is English, and knowledge of French is not a requirement.
The Institut Pasteur is situated in the center of Paris and benefits from a
multidisciplinary, and international campus. It is a vibrant, dynamic and
truly collaborative workplace.
On site we have access to many technological platforms (proteomics,
microscopy, flow cytometry, etc.) and the possibility to carry out cutting
edge techniques (single cell studies, multiomics analyses, etc.).
Interested candidates should submit a one page personal statement exposing
their previous track record of accomplishments and justification for interest
in the laboratory. A detailed CV, with bibliography and contact information
for 3 references is also required.
Applicants should send these documents to email@example.com, and be
expected to start beginning of 2023.