Description
Umeå University, Medicinska fakulteten
Umeå University is one of Sweden's largest institutions of higher
education with over 35,000 students and 4,200 faculty and staff. We are
characterised by world-leading research in several scientific fields and a
multitude of educations ranked highly in international comparison. Umeå
University is also the site of the pioneering discovery of the CRISPR-Cas9
genetic scissors - a revolution in genetic engineering that has been awarded
the Nobel Prize in Chemistry.
At Umeå University, everything is nearby. Our cohesive campus environment
makes it easy to meet, collaborate and exchange knowledge, which promotes a
dynamic and open culture where we rejoice in each other's successes.
Are you interested in knowing more about Umeå University as a workplace read
more at:Work with us.
The Faculty of Medicine, which consists of 13 departments, is responsible for
biomedical research and courses in the field of nursing and health care and
has an extensive research and graduate education in more than 80 subjects.
Postdoctoral position in a project on Cancer Biology: From Cellular Imaging
to Structural Biology
This position is part of the Faculty of Medicine's strategic investment in
innovative and cross-border research. We are looking for a full-time
postdoctoral fellow for two years for a research project where studies of
oncogenic signaling pathways that control cancer cells' ability to divide
cells and metastasize for prostate cancer take place in a translational
project group. Last application date is 13 June 2022.
Project description
The project is part of a multidisciplinary collaboration between four
research groups that aims to understand at the molecular level how two kinases
control tumor progression and metastasis of prostate cancer. The project
includes investigating how the Transforming Growth Factor β Type I receptor
(TβRI) and Aurora kinase B (AURKB) interact during cell division in cancer
cells. The significance of these kinases for tumor growth in preclinical and
clinical cancer models, will be studied. The project is translational and
includes studies of recombinant proteins using structural biology, in vitro
cell cultures using preclinical cancer models, real-time imaging using
Sartorius IncuCyte S5 technology, artificial intelligence and data-driven life
science, confocal microscopy and studies in human tumor materials. The project
aims to develop better predictive biomarkers for early detection of advanced
prostate cancer but also to develop improved treatment strategies for
aggressive prostate cancer.
Work duties and respoonsibilities
The work duties and respobsibilities include laboratory work with studies
of how TβRI and AURKB affect each other and thereby the ability of cancer
cells to cell division and invasiveness using preclinical cancer models and
advanced imaging technology of cells using Sartorius IncuCyte S5 and other
methods. The work is complemented by in vitro studies for interaction, which
includes the production of recombinant proteins for structural biology,
transient transfections of cell lines with mutated genes such as using CRISPR-
Cas9 technology for a molecular understanding to understand the function of
these kinases. In the long term, we want to understand how the oncogenic
signaling pathways they activate in cancer cells can be inhibited. The work
therefore requires close collaboration between different subject areas, see
below.
Eligibility
To qualify for this postdoctoral position, applicants must have a doctoral
degree, or a foreign degree that is deemed to correspond to a doctoral degree,
in cell biology, molecular biology, molecular pathology, structural biology or
biochemistry. This qualification requirement must be fulfilled no later than
at the time when the appointment decision is made.
Applicants who have defended their dissertations in one of the following two
defined areas will be considered for the position:
1) Cellular imaging in real time. For this specialization, the candidate is
expected to have a solid competence in data analysis and to either possess or
want to develop competence in AI-driven data analysis.
2) Structural biology and biochemistry. Within this competence orientation, a
candidate is expected to have a PhD in structural biology (either X-ray
crystallography or cryo electron microscopy) and possess a strong competence
in biochemistry.
The applicant must have solid knowledge and deep experience of traditional
biological laboratory methods in any of the fields of cell biology, molecular
biology, biochemistry or structural biology.
Additional desirable qualifications
Since employment as a postdoctoral fellow constitutes a merit-based
employment for junior researchers, we are primarily interested in applicants
who have completed their doctorate degree no more than three (3) years from
last application date. Applicants who have completed their degree prior to
this, may be considered if special circumstances exist. Special reasons
include absence due to illness, parental leave, clinical practice,
appointments of trust for a trade union organisation or other similar
circumstances, and for relevant duties/assignments within the subject area.
It is very meritorious if you have experience of independent work with cell
biology such as live-cell imaging and AI-driven data analysis, molecular
pathology, tumor biology, structural biology. In addition, it is desired that
one has worked with structural biological methods and issues. Knowledge of
genetic experimental methods such as transfections, cloning and the ability to
produce recombinant proteins is desirable. Knowledge of how kinases are
activated is also meritorious or experience of studies of predictive
biomarkers in human tumor materials is meritorious. It is also important if
you have previous experience of confocal microscopy or, for example, flow
cytometry to study cell cycle and genetic stability.
More about the employment
The employment is a fixed-term employment full-time for two years in
accordance with the terms of the agreement on fixed-term employment as a
postdoctoral fellow starting as soon as possible or by agreement.
More information about the groups' research can be read on our website:
The project is run in Landström's research group at the Department of Medical
Biosciences,
https: // www. umu.se/forskning/grupper/tgf-beta-signaling--tumor-biology-in-
prostate-cancer/ and in close collaboration between research groups at
Department of Chemistry:
Wolf-Watz research group https: // www. umu.se/nyheter/vetenskapligt-samfund-
intervjuar-professor-magnus-wolf-watz10846542/,
https: // www. umu.se/personal/magnus-wolf-watz/
Sauer Erikssons research group https: // www. umu.se/forskning/grupper/elisabeth-
sauer-eriksson-lab/
Tryggs research group https: // www. umu.se/personal/johan-trygg/
https: // www. umu.se/forskning/grupper/johan-trygg-lab/
Application
The application must contain :
A short description of the research interests and motivation for why you
are interested in the position.
Curriculum vitae (CV).
List of publications.
Diplomas from postgraduate education and other relevant degrees.
Contact information for two reference persons.
The application, written in Swedish or English must be submitted via our
e-recruitment system, Varbi. Deadline for submission of application for this
position is 13 June 2022.
We look forward to receiving your application!
Umeå University strives to offer an equal environment where open dialogue
between people with different backgrounds and perspectives lay the foundation
for learning, creativity and development. We welcome people with different
backgrounds and experiences to apply for the current employment.
We kindly decline offers of recruitment and advertising help.
Type of employment Temporary position longer than 6 months
Contract type Full time
Number of positions 1
Working hours 100%
City Umeå
County Västerbottens län
Country Sweden
Reference number AN 2.2.1-885-22
Contact
Maréne Landström, 090-7852458
Published 18.May.2022
Last application date 13.Jun.2022 11:59 PM CEST
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