Postdoctoral Position At C3M, Nice, France

Universities and Institutes of France

France

September 30, 2022

Description

  • Organisation/Company: Centre Méditerranéen de Médecine Moléculaire (C3M, Inserm U1065) - Team MicroCan
  • Research Field: Biological sciences › Biology Chemistry › Biochemistry Medical sciences
  • Researcher Profile: Recognised Researcher (R2) Established Researcher (R3)
  • Application Deadline: 30/09/2022 00:00 - Europe/Brussels
  • Location: France › Nice
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Offer Starting Date: 03/10/2022
  • Position

    Using a multidisciplinary approach, our laboratory has identified an original role of mechanical signals from the extracellular matrix of collagen in melanoma therapy resistance (Girard et al. Cancer Res 2020; Diazzi et al. Cancers 2020; Berestjuk et al. EMBO Mol Med 2022; Diazzi et al. EMBO Mol Med 2022). The accumulation of many oncogenic factors is modulated by the ubiquitin-proteasome system (UPS) and deubiquitinating enzymes (DUBs), a set of ubiquitin-specific proteases involved in most cellular processes, including melanoma cell survival (Didier et al. Mol Cancer Ther 2018; Ohanna et al. Cancers 2022). However, the contribution of DUBs in mechanobiology is still unexplored. Addressing both fundamental and translational questions, the objectives of the project is to better understand the molecular mechanisms linking DUBs to melanoma mechanotransduction and therapeutic response. The work will benefit from the team's expertise in melanoma biology, state-of-the- art technologies, pre-clinical mouse models as well as strong collaborations with clinicians, with the goal to identify new potential therapeutic targets.

    Offer Requirements Specific Requirements

    Applicant profile

    Applicants should have previous experience in Cell biology and/or Immunology. Prior experience in the analysis of tumor microenvironment in mouse models will be valuable. Expertise in the study of melanoma and/or the ubiquitin system would be appreciated. We are looking for a hard-working and highly motivated candidate.

    Contact Information
  • Organisation/Company: Centre Méditerranéen de Médecine Moléculaire (C3M, Inserm U1065) - Team MicroCan
  • Organisation Type: Large Company
  • Website: https:// www. c3m-nice.fr/en/Teams/en-equipe-11/
  • Country: France