Postdoctoral Fellowship position in Innate Immune Regulation and Autoinflammatory Disease Mechanisms

Indiana University East

United States

October 12, 2021

Description

Posting Details

Indiana University is an equal employment and affirmative action employer and a provider of ADA services. All qualified applicants will receive consideration for employment without regard to age, ethnicity, color, race, religion, sex, sexual orientation or identity, marital status, national origin, disability status or protected veteran status. Indiana University does not discriminate on the basis of sex in its educational programs and activities, including employment and admission, as required by Title IX. Indiana University's non-discrimination statement is found in policy UA-01 at https:// www. policies.iu.edu. Questions or complaints regarding Title IX may be referred to the U.S. Department of Education Office for Civil Rights or the university Title IX Coordinator. The address for Indiana University's Title IX Coordinator is: 400 E. 7th Street, Poplars 833, Bloomington, IN 47405. The Annual Security and Fire Safety Report, containing policy statements, crime and fire statistics for all Indiana University campuses, is available online at https: // protect.iu.edu/police-safety/annual-reports/index.html You may also request a physical copy by emailing IU Public Safety at iups@iu.edu or by visiting IUPD

Title Postdoctoral Fellowship position in Innate Immune Regulation and Autoinflammatory Disease Mechanisms

Specific Title Appointment Type Postdoctoral Fellow Department IUSM - Pediatrics Campus IU School of Medicine Indianapolis Position Summary

A postdoctoral position to study innate immune signaling pathways and immune regulation is available immediately in the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine.

The research project is aimed at understanding the regulation of signaling by innate pattern recognition receptors and sensors that activate the NF-kB family of transcription factors and type I IFN responses. In previous work we identified key domains in the NF-kB essential modulator, NEMO, that regulate inflammatory responses and immunity. (PNAS 2016 PMID: 26802121, JCI 2020 PMID: 31874111). The goal of this project is to learn how the biochemical mechanisms that control NF-kB and type I IFN responses are regulated by these domains and the role these mechanisms play in genetic immune deficiency and immune dysregulation. These findings will guide the development of novel therapies to treat and prevent more common autoimmune and autoinflammatory diseases.

Responsibilities The postdoctoral fellow will learn to employ an array of techniques utilizing advanced cell biology, biochemistry and molecular biology assays. The project involves characterizing mouse models of disease in genetically modified mice, and elucidating molecular mechanisms of protein regulation in primary patient samples, pluripotent stem cells, and engineered cancer cell lines.

As the nation's largest medical school, IUSM is committed to being an institution that not only reflects the diversity of the learners we teach and the patient populations we serve, but also pursues the values of diversity, equity and inclusion that inform academic excellence. We desire candidates who enhance our representational diversity, as well as those whose work contributes to equitable and inclusive learning and working environments for our students, staff, and faculty. IUSM strives to take an anti-racist stance, regularly evaluating and updating its policies, procedures, and practices to confer equitable opportunities for contribution and advancement for all members of our community. We invite individuals who will join us in our mission to advance racial equity to transform health and wellbeing for all throughout the state of Indiana.

Basic Qualifications

Doctorate or terminal degree required. PhD in Biochemistry, Molecular or Cell Biology, Immunology, or a related field and/or MD with an interest in Immunology and Genetics. The candidate will work closely with others in a team setting as well as independently. Experience working with mice and human patient samples is desirable.

Department Contact for Questions

Dr. Eric Hanson, M.D. Associate Professor in Pediatrics, Microbiology and Immunology, and Medical and Molecular Genetics Division Chief, Pediatric Rheumatology at erichans@iu.edu

Additional Qualifications Special Instructions

Position #00048815 IN-PRHR

Priority Application Review Deadline Expected Start Date OAA # IUSM011702016

Supplemental Questions

Required fields are indicated with an asterisk ().

  • How did you hear about this position?
  • Personal Contact: At Professional Meeting or Conference
  • Personal Contact: Direct Contact by Search Committee
  • Personal Contact: Referred by colleague or advisor
  • Personal Contact: School of Medicine recruiter
  • Personal Contact: IUHP Physician Recruiter
  • Announcement: Other Journal or Magazine
  • Announcement: Other Website
  • Are you a dual career partner (your partner or spouse is already being recruited)?
  • Yes
  • No
  • Applicant Documents

    Required Documents

  • Curriculum Vitae
  • Letter of Application
  • Optional Documents

  • List Of References
  • Letter of Reference 1
  • Letter of Reference 2
  • Letter of Reference 3
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