Information about the project and the research groups
This postdoc position is a collaboration between the groups of
Professor Fredrik Westerlund and Professor Marcus Wilhelmsson.
The postdoctoral fellow will investigate DNA and RNA using single-molecule
biophysical techniques and in particular an optical tweezers setup
specifically designed to stretch short DNA/RNA molecules. More specifically
the fellow will utilize base-modified nucleic acids to increase the
understanding regarding the intramolecular forces of nucleic acids (pi-
stacking, hydrogen bonding, hydrophobicity). Secondary structures of DNA and
RNA (B- and A-form duplexes) to the more complex tertiary structures of RNA
will be investigated. Moreover, interactions between nucleic acids and
proteins, in particular proteins involved in DNA repair, will be monitored
using the same mini-tweezer setup. Complementary single molecule and bulk
techniques will also be used.
Two recent papers are:
https: // pubs.rsc.org/en/content/articlelanding/2021/cp/d1cp01985f
https: // www. mdpi.com/1422-0067/22/16/9008
The Westerlund group at the Department of Biology and Biological Engineering,
Division of Chemical Biology at Chalmers uses nanofluidic devices to study
biomolecules in general and DNA in particular. The group's projects range from
fundamental biophysics of DNA-protein interactions to analysis of clinical
DNA, for example diagnostics of antibiotic resistance. For more information
see homepage of the Westerlund group and recent publications listed there:
The specific goals of the Wilhelmsson research group are to develop novel
probe molecules for DNA/RNA systems, new improved fluorescence methods for
biochemical investigations and use fluorescent probes and techniques to study
DNA/RNA-protein/ligand interactions both structurally and dynamically. The
research is partly performed in close collaboration with pharmaceutical
industry (AstraZeneca). For more information see homepage of the Wilhelmsson
group and recent publications listed there:
The postdoctoral fellow is expected to provide state-of-the-art knowledge
in the single-molecule nucleic acid biophysics research area and to take a
lead at the division in the utilization and methodology development of the
nucleic acid mini-tweezer equipment.
To qualify for the position you must have a PhD degree in a relevant field
such as biophysical chemistry or equivalent area. If you have experience in
single molecule biophysics focused on nucleic acids, or optical tweezers, this
is seen as meritorious. To be successful you also need to be energetic, have a
problem-solving attitude and enjoy working both by yourself as well as closely
together with others.
Full-time temporary employment. The position is limited to a maximum of two
We offer Chalmers offers a cultivating and inspiring working environment in the
coastal city of Gothenburg.
Read more about working at Chalmers and our benefits for employees.
Chalmers aims to actively improve our gender balance. We work broadly with
equality projects, for example the GENIE Initiative on gender equality for
excellence. Equality and diversity are substantial foundations in all
activities at Chalmers.
The application should be marked with Ref 20210552 and written in English.
The application should be sent electronically and be attached as pdf-files, as
CV: (Please name the document as: CV, Surname, Ref. number)
• CV, include complete list of publications
• Previous teaching and pedagogical experiences
• Two references that we can contact.
Personal letter: (Please name the document as: Personal letter, Family
name, Ref. number)
1-3 pages where you: • Introduce yourself • Describe your previous research fields and main research results • Describe your future goals and future research focus
• Attested copies of completed education, grades and other certificates.
Please use the button at the foot of the page to reach the application form.
The files may be compressed (zipped).
Application deadline: 31 December, 2021
For questions, please contact:
Professor Marcus Wilhelmsson, Dept of Chemistry & Chemical Engineering
Professor Fredrik Westerlund, Dept of Biology and Biological Engineering
Chalmers declines to consider all offers of further announcement
publishing or other types of support for the recruiting process in connection
with this position.
Chalmers University of Technology conducts research and education in
engineering sciences, architecture, technology-related mathematical sciences,
natural and nautical sciences, working in close collaboration with industry
and society. The strategy for scientific excellence focuses on our six Areas
of Advance; Energy, Health Engineering, Information and Communication
Technology, Materials Science, Production and Transport. The aim is to make an
active contribution to a sustainable future using the basic sciences as a
foundation and innovation and entrepreneurship as the central driving forces.
Chalmers has around 11,000 students and 3,000 employees. New knowledge and
improved technology have characterised Chalmers since its foundation in 1829,
completely in accordance with the will of William Chalmers and his motto: