atthe Department of biochemistry and biophysics. Closing date: 5 September
SciLifeLab is a national center for molecular biosciences with focus on health
and environmental research. The center combines frontline technical expertise
with advanced knowledge of translational medicine and molecular bioscience.
SciLifeLab is a national resource hosted by Karolinska Institutet, KTH Royal
Institute of Technology, Stockholm University and Uppsala University. The
center also collaborates with several other universities.
Mats Nilsson's research group at the Department of Biochemistry and Biophysics
(DBB) is located at SciLifeLab in Solna, and is now seeking a postdoctoral
fellow to perform and optimize spatial single-cell multi-omics technology.
The field of spatially resolved omics is emerging to provide new insights
into the spatial organization of tissues and organs at the molecular level.
The Targeted Spatial Omics (TSO) units within the SciLifeLab Spatial and
Single Cell Biology platform has been launched this year with the mission to
provide in situ sequencing (ISS, PI: Mats Nilsson/Chika Yokota), single-
molecule fluorescence in situ hybridization (smFISH, PI: Magda Bienko/Xiaoze
Li Wang) and multiplexed immunofluorescence (CODEX, PI: Emma
Lundberg/Charlotte Stadler) service to scientists across the country. The
platform has also a mission to develop new capabilities, and that is the main
objective of the postdoc. The position is closely linked to the platform units
and to the research groups at SciLifeLab, pioneering these spatial omics
With the support of a dedicated grant from Vetenskapsrådet, there is an
opening for a postdoctoral fellow at the Mats Nilsson's group in spatial
single-cell multi-omics. The aim of the project is to establish integrated
protocols of TSO technologies, in order to make these state-of-the-art
technologies to be effectively deployed by a wide research community,
particularly in biotech/pharma and hospitals. The project will focus on
developing useful analysis pipelines for clinical oncology research.
Currently, there is no protocol for integrating ISS/FISH/CODEX on the same
sample. However, multi-modal data collection from the same tissue section is
desirable especially in the case of precious samples, such as small biopsies.
A particular focus will be, therefore, on identifying optimal conditions that
allow performing different types of sequential assays on the same sample.
The postdoc will participate in the project and contribute to general
reseach group activities and responsibilities. The postdoc will be responsible
for establishing the protocols for sequential assays, such as (i) DNA/RNA
FISH followed by CODEX; (ii) ISS followed by CODEX; (iii) mutation
detection by ISS followed by CODEX. As such, the successful candidate will
operate closely with the TSO research groups and the platform to jointly
develop laboratory research protocols, including handling tissue, performing
TSO technologies, handling sensitive instruments such as fluorescence
microscopes and liquid handling robots, and storing, sharing and tracking
samples and data. The role also includes setting up pipe lines for integrated
analysis of the data, mainly in collaboration with bioinformaticians from the
Bioinformatics platform at SciLifeLab.
Postdoctoral positions are appointed primarily for purposes of research.
Applicants are expected to hold a Swedish doctoral degree or an equivalent
degree from another country.
The degree should have been completed no more than three years before the
deadline for applications. An older degree may be acceptable under special
circumstances, which may involve sick leave, parental leave, clinical
attachment, elected positions in trade unions, or similar.
In the appointment process, special attention will be given to research
skills. Doctoral degree should be from a relevant field e.g. Cell Biology,
Molecular Biology, Biochemistry, Biomedical Science, Biotechnology or similar
discipline and the applicant should have experience with standard molecular
and cellular biological techniques. The applicant should also have previous
experience with microscopy. The applicant should be fluent enough in Python
and/or R to be an advanced user of different open-source analysis packages.
Experience in in situ hybridization, immunohistochemistry or similar
techniques is highly desirable. Good knowledge and experience in bioimage
analysis will be highly valued. The successful candidate should enjoy learning
new methods, and should be able to demonstrate an ability to complete projects
within a defined time frame. Previous work in the field of cancer research is
an advantage. Excellent interpersonal, organizational skills, communication
skills and good knowledge of English are essential. Emphasis will be placed on
qualities of responsibility, flexibility, teamwork and ability to solve
Terms of employment
The position involves full-time employment for a maximum of two years, with
the possibility of extension under special circumstances. Start date as per
Stockholm University strives to be a workplace free from discrimination and
with equal opportunities for all.
Further information about the position can be obtained from Professor Mats
Nilsson, telephone: +46 73 053 78 76, firstname.lastname@example.org.
Ingrid Lander (Saco-S), telephone: +46 708 16 26 64, email@example.com,
Alejandra Pizarro Carrasco (Fackförbundet ST/Lärarförbundet), telephone: +46
8 16 34 89, firstname.lastname@example.org, and email@example.com (SEKO).
Apply for the position at Stockholm University's recruitment system. It is the
responsibility of the applicant to ensure that the application is complete in
accordance with the instructions in the job advertisement, and that it is
submitted before the deadline.
Please include the following information with your application
Your contact details and personal data
Your highest degree
Your language skills
Contact details for 2–3 references
and, in addition, please include the following documents
Cover letter that also describes (max 2 pages):
– why you are interested in the field/project described in the advertisement
– why and how you wish to complete the project
– what makes you suitable for the project in question
CV – degrees and other completed courses, work experience and a list of
Copy of PhD diploma
Letters of recommendation (no more than 3 files)
Publications in support of your application (no more than 3 files).
The instructions for applicants are available at: How to apply for a position.
You are welcome to apply!
Stockholm University contributes to the development of sustainable democratic
society through knowledge, enlightenment and the pursuit of truth.
Closing date: 05/09/2021