Postdoctoral Fellow in Host-Microbe Interaction

Indiana University East

United States

October 14, 2021

Description

Posting Details

Indiana University is an equal employment and affirmative action employer and a provider of ADA services. All qualified applicants will receive consideration for employment without regard to age, ethnicity, color, race, religion, sex, sexual orientation or identity, marital status, national origin, disability status or protected veteran status. Indiana University does not discriminate on the basis of sex in its educational programs and activities, including employment and admission, as required by Title IX. Indiana University's non-discrimination statement is found in policy UA-01 at https:// www. policies.iu.edu. Questions or complaints regarding Title IX may be referred to the U.S. Department of Education Office for Civil Rights or the university Title IX Coordinator. The address for Indiana University's Title IX Coordinator is: 400 E. 7th Street, Poplars 833, Bloomington, IN 47405. The Annual Security and Fire Safety Report, containing policy statements, crime and fire statistics for all Indiana University campuses, is available online at https: // protect.iu.edu/police-safety/annual-reports/index.html You may also request a physical copy by emailing IU Public Safety at iups@iu.edu or by visiting IUPD

Title Postdoctoral Fellow in Host-Microbe Interaction

Appointment Status Non-Tenure Track Department IU Bloomington Biology Position Summary

A postdoctoral position is available as part of a collaborative project between the Newton (https: // discogenome.wordpress.com/) and Hardy (https:// thehardylab.mystrikingly.com/) laboratories, in the Department of Biology, Indiana University, Bloomington.

This position is part of an NSF Rules of Life: Microbiome Theory and Mechanisms award focused on identifying how microbes alter the epitranscriptome.

Successful host-associated microbes sculpt host cell biology in ways that are useful to them. Often, these changes in host biology alter the ability of other microbes to colonize, protecting the host niche for the first microbe. For example, colonization of insects with Wolbachia endosymbionts can preclude infection by viruses. This fact has led to the deployment of Wolbachia- infected mosquitos across the globe to limit the transmission of vectored diseases. We have identified RNA modifications induced by Wolbachia that directly alter Drosophila cell biology and affect the ability of viruses to colonize. Wolbachia upregulates a host methyltransferase to limit virus replication and our preliminary data suggest that the virus genome itself is modified in a Wolbachia infected cell, altering mRNA stability. These data lead us to ask “How does a microbial symbiont alter the epitranscriptomic landscape of host cells?”

The ideal candidate will have experience in Drosophila, molecular virology, and/or bioinformatics. The candidate will be trained in molecular virology, and the use of direct sequencing approaches (PacBio and ONT) to identify modified nucleotides.

The position will be funded for up to three years, with the potential to extend for an additional year.

Basic Qualifications

A Ph.D. in microbiology, virology, bioinformatics, entomology, or a related field is required at time of appointment.

Department Contact for Questions

Inquiries about the position can be directed to Irene Newton (irnewton@indiana.edu).

All other inquiries can be directed to Jeremy Bennett (jebennet@indiana.edu).

Additional Qualifications Salary and Rank Salary will be commensurate with experience, and full benefits are included. Special Instructions

To apply, please submit (i) a letter of application, (ii) a full CV, (iii) a statement of research interests, and (iv) contact information for three references electronically to https:// indiana.peopleadmin.com/postings/10897.

The College of Arts and Sciences is committed to building and supporting a diverse, inclusive, and equitable community of students and scholars.

For Best Consideration Date 06/18/2021 Expected Start Date 11/01/2021 OAA # 22105-03

Supplemental Questions

Required fields are indicated with an asterisk ().

Applicant Documents

Required Documents

  • Letter of Application
  • Curriculum Vitae
  • Research Agenda
  • Optional Documents

  • List Of References
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