Postdoctoral Biochemist & Molecular Pharmacologist

University of Oxford

United Kingdom

October 10, 2022


Postdoctoral Biochemist & Molecular Pharmacologist

Centre for Medicines Discovery, NDM Research Building, Old Road Campus, Headington, Oxford, OX3 7FZ

We are seeking to appoint a Postdoctoral Biochemist & Molecular Pharmacologist to join our Centre for Medicines Discovery, University of Oxford.

You will be responsible for designing and performing experiments with the expectation that you will be able to write protocols, design experimental plans and develop new scientific techniques. You will work closely with protein expression & purification scientists, chemists and neurobiologists to research the molecular mechanisms at play in the pathogenesis of neurodegenerative disease, particularly the role of ApoE and the relationship between it, its receptors and Tauopathy. You will develop biochemical, biophysical and target engagement assays, and utilise them to identify and evaluate ligands. You will independently use and manage specialist scientific equipment in a laboratory environment, such as Labcyte Echo (automated liquid handling), Pherastar and FLIPR plate readers, Biacore (SPR), ITC, Octet (BLI), RapidFire mass spectrometry. As part of your responsibilities, you will manage your own research on a number of dementia projects and administrative activities, such as data entry into data bases and maintaining electronic lab notebooks. Carefully analyse data, report the results and devise plans to progress.

It is essential that you hold a PhD or DPhil (or close to competition) in biochemistry, pharmacology, or other similar subject; together with previous experience of in vitro assay development including one or more of: biochemical, biophysical assays, protein-protein interaction assays and/or cellular target engagement assays. You will be reliable, well organised and be able to show meticulous attention to detail, including at the practical level of statistical analysis and scientific controls; together with the interest in studying the molecular pathology of neurodegenerative diseases. You will have background in protein biochemistry/enzymology with experience of determination of drug mechanism of action and past research applicable to molecular pharmacology and the understanding of structure/function and the modulating effects of disease mutations or of ligands with pharmacological effects.

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

This position is offered full time on a fixed term contract until 31 July 2024 and is funded by the Rainwater Charitable Foundation.

Only applications received before 12 midday on Monday 10 October 2022 will be considered. Please quote 159732 on all correspondence.

Contact Person : Margarita Monroy Vazquez Vacancy ID : 159732 Contact Phone : Closing Date & Time : 10-Oct-2022 12:00 Pay Scale : STANDARD GRADE 7 Contact Email : Salary (£) : £34,308 - £42,155 with a discretionary range to £46,047 per annum

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The University of Oxford is the oldest university in the English-speaking world, and is actually so ancient that its founding date is unknown – though it is thought that teaching took place there as early as the 11th century. It’s...