Postdoctoral Biochemist & Molecular Pharmacologist
Centre for Medicines Discovery, NDM Research Building, Old Road Campus,
Headington, Oxford, OX3 7FZ
We are seeking to appoint a Postdoctoral Biochemist & Molecular Pharmacologist
to join our Centre for Medicines Discovery, University of Oxford.
You will be responsible for designing and performing experiments with the
expectation that you will be able to write protocols, design experimental
plans and develop new scientific techniques. You will work closely with
protein expression & purification scientists, chemists and neurobiologists to
research the molecular mechanisms at play in the pathogenesis of
neurodegenerative disease, particularly the role of ApoE and the relationship
between it, its receptors and Tauopathy. You will develop biochemical,
biophysical and target engagement assays, and utilise them to identify and
evaluate ligands. You will independently use and manage specialist scientific
equipment in a laboratory environment, such as Labcyte Echo (automated liquid
handling), Pherastar and FLIPR plate readers, Biacore (SPR), ITC, Octet
(BLI), RapidFire mass spectrometry. As part of your responsibilities, you
will manage your own research on a number of dementia projects and
administrative activities, such as data entry into data bases and maintaining
electronic lab notebooks. Carefully analyse data, report the results and
devise plans to progress.
It is essential that you hold a PhD or DPhil (or close to competition) in
biochemistry, pharmacology, or other similar subject; together with previous
experience of in vitro assay development including one or more of:
biochemical, biophysical assays, protein-protein interaction assays and/or
cellular target engagement assays. You will be reliable, well organised and be
able to show meticulous attention to detail, including at the practical level
of statistical analysis and scientific controls; together with the interest in
studying the molecular pathology of neurodegenerative diseases. You will have
background in protein biochemistry/enzymology with experience of determination
of drug mechanism of action and past research applicable to molecular
pharmacology and the understanding of structure/function and the modulating
effects of disease mutations or of ligands with pharmacological effects.
Applications for this vacancy are to be made online and you will be required
to upload a supporting statement and CV as part of your online application.
Your supporting statement must explain how you meet each of the selection
criteria for the post using examples of your skills and experience.
This position is offered full time on a fixed term contract until 31 July 2024
and is funded by the Rainwater Charitable Foundation.
Only applications received before 12 midday on Monday 10 October 2022 will be
considered. Please quote 159732 on all correspondence.
Contact Person : Margarita Monroy Vazquez Vacancy ID : 159732
Contact Phone : Closing Date & Time : 10-Oct-2022 12:00
Pay Scale : STANDARD GRADE 7 Contact Email :
Salary (£) : £34,308 - £42,155 with a discretionary range to £46,047 per