New York University: NYU - NY: College of Dentistry: Molecular
Sep 24, 2019
We are looking to recruit a Postdoctoral Associate candidate for our newly
initiated research program centered around compartmentalized G protein
signaling by internalized G protein-coupled receptors (GPCRs) in Thomsen
lab, New York University. The main objective of the research program is to
understand the mechanistic basis behind compartmentalized GPCR signaling at a
near-atomic level, and to study its direct implications on a variety of
physiological and pathophysiological conditions including cancer metastasis,
nociception, and salt/water homeostasis.
The primary project of the successful candidate will be to investigate the
mechanism and contribution of compartmentalized chemokine receptor signaling
to cell migration and metastasis of melanoma cells. The project will involve
work with primary metastatic tissue isolated from patients as well as melanoma
cell lines where an in-depth mechanism of cell migration is sought through
usage of proteomics approaches as well as cutting-edge cryo-electron
microscopy. The insights learned from this project will be used to design
future drug candidates to combat metastatic melanoma.
In addition, it is also expected that the applicant will participate in
related secondary projects and collaborative projects within and/or
outside our laboratory.
We are looking for candidates with a Ph.D. and/or M.D. degree and experience
in cell biology, proteomics, and/or electron microscopy . Prior
knowledge of GPCR signal transduction is preferred but not essential. We are
looking for motivated and creative individuals with a commitment to
academic research who can work independently as well as in team-based
projects. Good oral and written communication skills are musts.
PhD and/or MD in Biomedical Research required
Cellular and Molecular Biology: Cell culture, molecular cloning, cell
migration assays, cell-based signaling assays, confocal and live cell
fluorescence microscopy, genetic manipulation of cell lines by CRISPR and
Proteomics: Mass spectroscopy, APEX2, data processing.
Electron Microscopy: Grid preparation, cryo-EM, cryo-electron tomography,
negative stain EM, data processing.
Please submit a resume/CV and at least three reference letters addressed to
Dr. Alex Thomsen, PhD, Assistant Professor, Department of Basic Science &
Craniofacial Biology, New York University College of Dentistry, 345 East 24th
Street, Room 902A, New York, NY 10010.
This institution is using Interfolio's Faculty Search to conduct this search.
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