Postdoctor in Kidney Cancer Reaearch

Lund University

Sweden

September 26, 2021

Description

Lund University, Faculty of Medicine, Dept of Laboratory Medicine, Lund

Lund University was founded in 1666 and is repeatedly ranked among the world's top 100 universities. The University has around 44 000 students and more than 8 000 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.

The Faculty of Medicine is a part of Lund University, and is responsible for education and research within medicine and healthcare. Our academic programs are closely linked with the healthcare system and are firmly anchored in the faculty's strong research tradition. Our research spans a broad field within experimental preclinical research, near-patient clinical research and health sciences research. The Faculty of Medicine, with its 1,800 employees and 2,700 students in Lund and Malmö, is a knowledge-intensive meeting place for students, teachers and researchers from all over the world.

The Department of Laboratory Medicine is one of six departments at Lund University's Faculty of Medicine. We conduct leading research, both broad and specialised, within the field of laboratory medicine, focusing on the onset of disease and how we can improve diagnostics and treatment for patients. Some of our strongest areas with world-class research deal with cancer, genetics and blood.

The Research Group

The Division of Translational Cancer Research (TCR) was founded 2013 in conjunction with the formation of Lund University Cancer Center (LUCC) at Medicon Village. TCR consists of ten research groups with different areas of expertise, but together working on projects with the common goal of improving cancer diagnostics and cancer therapy. Our multidisciplinary experimental settings include human genetics, mouse genetics, human tissue platform, stem cell biology and advanced imaging, aiming at creating novel diagnostic tools and therapeutic modalities. The overarching goal at TCR is to open up new horizons that will give the opportunities for novel diagnostic and treatment modalities for cancer treatment. The kidney cancer group at TCR has for a long time been focusing on studies of renal malignancies, with particular focus on kidney cancer genetics in relation to the normal function of the many different cell types in the kidney. Key biological processes in the transformation process are studied using a variety of model systems and techniques with the aim to identify targetable biomarkers for the disease. Please read more about our research here.

Within the group, we aim to maintain a good working environment based on mutual respect and consideration. We constantly strive to improve the conditions for work, development and participation for all employees.

The employment is a full time position, time limited to two years, regulated by central agreements regarding post-doctoral employments, with the desired access date on November 15, 2021, or according to agreement.

Work assignments and area of expertise

In this postdoctoral project the main aim is to explore the links between loss of the tumor suppressor gene VHL and transformation of normal proximal tubule cells of the kidney. The task includes experimental studies on the transcriptional cues activated by hypoxia. Different experimental models of normal and malignant kidney cells will be subjected to treatment with a variety of modulators of the hypoxic response and the treated cells will be analysed with functional and genomic approaches. The obtained results will be explored by using different bioinformatic tools.

The work will be highly team-oriented, both through internal and external collaborations, which necessitates excellent collaboration and communication skills to successfully fill this position. External collaborations may for example involve local researchers from Lund University.

The main work duties are:

  • Studies of the hypoxic response in normal and malignant kidney cells
  • Application of both DNA- and RNA-based methods (WES, RNA-seq, single cell seq etc.) for characterization of the model system
  • Providing expertise in bioinformatic analyses, in particular RNA-seq
  • Various types of analyses of patient cohorts with respect to disease progression etc in relation to given biomarkers
  • Computational analyses of TMA based immunohistochemistry from large patient cohorts and of proteomics data
  • Assessment criteria and other qualifications

    This is a career development position primarily focused on research. The position is intended as an initial step in a career, and the assessment of the applicants will primarily be based on their research qualifications and potential as researchers.

    Particular emphasis will be placed on research skills within the subject.

    For appointments to a post-doctoral position, the ability to develop and conduct high quality research and also teaching skills will be evaluated as part of the assessment criteria.

    Qualifications

    Appointment to a post-doctoral position requires that the applicant has a PhD, or an international degree equivalent to a PhD, within a subject related to the position, completed no more than three years before the last date for applications. Under special circumstances, the doctoral degree can have been completed earlier.

    Qualifications required:

  • Doctoral degree in a relevant research field (e.g. kidney biology or equivalent)
  • Very good knowledge about, and documented practical experience of work with model systems of normal and malignant kidney cells
  • Excellent knowledge in analyses of drug treatment response in vitro
  • Knowledge in transcriptomic analyses and visualisation
  • A good ability to master complex model systems in relation to normal function of the kidney
  • At least 4 years of practical experience of working with cell biology in general and kidney biology in particular
  • Very good oral and written communication skills in English
  • Great emphasis will be placed on personal suitability. You must have excellent communication and collaboration skills as well as be able to conduct your work independently and with high quality. Finally, you must demonstrate good planning, structural and prioritization skills.

    The following are merits for the position:

  • Experience of laboratory work, based on model systems of normal and malignant tissues
  • Experience from high through-put drug screening
  • Previous project management experience
  • Terms of employment

    This is a full-time, fixed-term employment of a maximum of 2 years. The period of employment is determined in accordance with the agreement “Avtal om tidsbegränsad anställning som postdoktor” (“Agreement on fixed-term employment as a post-doctoral fellow”) between Lund University, SACO-S, OFR/S and SEKO, dated 4 September 2008.

    Instructions for your application

    The application must contain a personal letter describing how you fulfill the desired qualifications, a CV and diploma.

    Other

    The university applies individual salary setting. Please indicate your salary claim in your application.

    Lund University welcomes applicants with diverse backgrounds and experiences. We regard gender equality and diversity as a strength and an asset. We kindly decline all sales and marketing contacts.

    To apply, please click the button "Login and apply"

    Type of employment Temporary position longer than 6 months

    Contract type Full time First day of employment November 15, 2021, or according to agreement Salary Monthly salary Number of positions 1 Working hours 100 City Lund County Skåne län Country Sweden Reference number PA2021/2865 Contact

  • Håkan Axelson, recruiting manager, +46462226434
  • Emelie Falck, HR coordinator, 046-2220000
  • Published 10.Sep.2021 Last application date 26.Sep.2021 11:59 PM CEST

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