Postdoctor In Cancer Research

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The Institute of Clinical Sciences is one of six Institutes within Sahlgrenska Academy at the University of Gothenburg. We conduct research and education that puts people's health and quality of life in focus. We represent 16 different research areas and are divided into four sections. Through a fruitful collaboration with the healthcare and Sahlgrenska University Hospital, we have developed joint projects and meeting places that benefits both health care and research

The Department of Surgery at the Sahlgrenska Academy at the University of Gothenburg invites applications for a postdoctoral position in cancer research, with placement at the Sahlgrenska Center for Cancer Research. The research group has a strong desire to generate novel targets for cancer therapy and translate basic research findings into new and innovative clinical trials.

The project will be conducted at the Sayin lab which is positioned in the intersection between lung cancer therapeutics, cancer metabolism and redox biology. We are building a precision medicine platform combining the latest technologies in lung cancer research and metabolomics to establish an extensive translational lung cancer group at Sahlgrenska Center for Cancer Research.

Cancer research with a focus on neurobiology and immunology

The purpose of the project is to identify therapeutic targets for treatment of brain metastasis in patients diagnosed with lung cancer. Most deaths in lung cancer patients are due to lung cancer metastasis, in which case the brain is the most common target organ, with brain metastasis happening in about half of all cases as the disease progresses, where BM are detected in 21% of patients with lung cancer at the time of diagnosis. While there have been great advances in the treatment of the primary lung tumors, treatments targeting the secondary brain metastasis tumors are scarce. We have established a model for investigation of non-small cell lung carcinoma lung adenocarcinoma brain metastasis. We aim to study effects of membrane bound proteins on brain metastasis in an in vivo CRISPR/CAS9 screen. Following identified targets for pharmacological modulation of cancer cell blood brain barrier invasion novel modulating compounds will be synthesized. Today, treatment for lung cancer BM is scarce. Patients typically don't survive more than six months. New targets and molecules can significantly improve mortality.

The research project aims mainly at studying molecular mechanisms which underlie lung cancer associated blood brain barrier cell invasions using new animal and cell models. The goal is to improve prevention and treatment of brain metastasis. The position contains a lot of laboratory work, problem solving as well as implementing new techniques in the laboratory. Identifying and setting-up relevant new collaborations is also expected for a successful project. The postdoctoral fellow will also be required to teach and supervise graduate and undergraduate students in the lab.

To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made.

In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area.

The successful candidate should have experience in the field of cancer biology, strong experience of animal and cell model development. Other requirements are extensive practical laboratory experience, experience with molecular biology techniques such as cloning, Western blot, primary culturing and cancer-related assays, experience in working with therapeutic drugs, rodent in vivo experience. Having experience of microscopy techniques such as live cell imaging is beneficial and strong experience using in vivo models for investigation of peripheral and central nervous system interactions and documented knowledge of sensory neuroscience is highly meriting. Besides being able to drive the project, the candidate should also be able to work in close collaboration with other lab members and have experience in teaching graduate and under-graduate students. Meriting is strong self-discipline, problem- solution oriented workstyle, organizational skills and good communicative and interpersonal team skills. It is understood that the applicant masters scientific writing in English and has good general communication skills in English.

Following the qualitative overall assessment of skills and proficiency, applicants will be selected who are expected to have the best prerequisites for implementing and developing current tasks as well as contributing to a positive development of the scientific group.

The employment is limited (temporary) for 24 months, 100 % of full-time and is placed at Department of Surgery at Institute of Clinical Sciences. Starting date; As soon as possible.

If you have any questions about the position, please contact Senior Lecturer Volkan Sayin; phone: +46 31-7866971 or e-mail: [email protected] or Researcher Clotilde Wiel; phone: +46 736 966 545 or e-mail: [email protected]

Union representatives at the University of Gothenburg can be found here: https: // www. gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande

Application

Submit your application via the University of Gothenburg's recruitment portal by clicking the “Apply” button. The applicant is asked to provide:

1. Detailed CV 2. List of publications / manuscripts 3. A letter describing why the position has been applied for, future research plans and qualifications in relation to the advertised position 4. Two references with names and addresses

It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.

Applications must be received by: 2024-09-12

Information for International Applicants

Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit:

https: // www. gu.se/en/about-the-university/welcome-services https: // www. movetogothenburg.com/

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden's regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.