Postdoc position: Investigating mechanisms of brain aging through in vivo CRISPR screens

ETH Zurich


February 26, 2022


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  • Postdoc position: Investigating mechanisms of brain aging through in vivo

    CRISPR screens

    100%, Basel, fixed-term

    The Laboratory for Biological Engineering (Prof. Randall J Platt) at ETH Zurich in Basel develops genome engineering technologies and applies them to a range of fundamental and disease-focused areas (www. To advance these efforts we are seeking a full-time postdoc with expertise in molecular and cellular biology, mouse models of neurodegeneration, viral vectors, and deep sequencing library preparation.

    Job description

    We are looking for a researcher to join our multidisciplinary team of scientists and work on a new collaborative project focused on gaining insight into the molecular mechanisms of brain aging and neurodegeneration through the use of in vivo CRISPR screens. The candidate will be passionate about science, technology, collaboration, communication, and translatable research.

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  • The ideal candidate should have a Ph.D. or equivalent in Molecular and Cellular Biology, Biochemistry, Neuroscience, Molecular Medicine, or a related field.
  • The candidate must have extensive experience working with a range of molecular and cellular methods, including standard molecular biology techniques (molecular cloning, RT-qPCR/ddPCR, western blot etc.), mouse handling and tail vein injection, tissue processing for DNA/RNA extraction, histology, and preparation of deep sequencing libraries for functional genomics experiments.
  • Expertise with stereotaxic surgery or molecular and behavioral characterization of neurodegenerative mouse models are major advantages.
  • Other valued skills include prior experience with mammalian cell culture, virus production, flow cytometry, or single-cell RNA-sequencing, and knowledge in bioinformatics, statistics, or programming.
  • The candidate must have a strong track record and interest in collaboration with multi-disciplinary scientists.
  • Mastery of oral and written English and the ability to communicate effectively in a highly interdisciplinary and international environment are required.
  • ETH Zurich

    ETH Zurich is one of the world's leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.

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    We look forward to receiving your application including, as a single PDF:

  • Cover letter that mentions your scientific interests and why you are interested in the group
  • CV
  • Diplomas and course transcripts
  • Contact details of three referees
  • Please submit your applications online. Applications via email will not be considered. For questions about the position, please contact Prof. Platt ( (no applications please).

    In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

    Apply online now

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