Postdoc position: Intestinal microbiota and lifelong immunity
We are recruiting a postdoctoral fellow to study the immune-microbial
relationship early in life and consequences of their perturbation on lifelong
The symbiotic microorganisms colonize all mucosal body surfaces of newborns
and play a key role in shaping the development and maturation of immune
system. In the intestine, the first vigorous immune response to colonizing
bacteria after birth occurs at weaning. This response termed "weaning
reaction" is critical for generating an immune memory that dictate the
tolerance or the susceptibility to multiple inflammatory pathologies later in
life (Al Nabhani et al., Immunity 2019, Nature Metabolism 2019). In the
framework of ERC starting project, we are seeking to gain knowledge regarding
the immunological and microbiological mechanisms behind the weaning reaction.
We aim to assess the dietary and microbial components that influence immune
memory generation and impact the susceptibility to develop both metabolic
disorders and immune-mediated diseases. The successful candidate will work on
the project using different transgenic germ-free and gnotobiotics mouse models
and acquiring variety of techniques including flow cytometry, scRNAseq, mass
spectrometry and shotgun metagenomic sequencing.
The post-holder will be supported by a well-funded interdisciplinary research
program in a young and dynamic environment at the Department for BioMedical
Research (DBMR), University of Bern, and at the Hospital University of Bern
(Inselspital), Switzerland. We work closely with groups of Prof. Andrew
Macpherson and Prof. Stephanie Ganal-Vonarburg, and we are involved in joint
lab meetings and journal clubs. We are now developing an international
collaborative network in which the postdoc will be involved.
The applicant must have a doctorate (PhD) degree obtained after January 2019
or will defend his/her PhD within the next six months. The candidate should
have a strong interest in mucosal immunology and microbiota and must be highly
experienced in working with mouse models and multicolor flow cytometry.
Expertise in epigenetic, molecular biology, or analysis of microbiome datasets
are advantages. Demonstrated competence to independently conduct experiments
and analyses, and willingness to collaborate internally and externally are
mandatory. The applicant needs to have at least one first author publication
in a peer reviewed journal.
We provide excellent scientific opportunities in a highly motivating
environment with a multidisciplinary approach to immunology and microbiology
discussions as well as seminars with wide-range topics. The project offers a
special opportunity to be trained on experimental mucosal immunology using
germ-free and gnotobiotic mouse models. We offer close supervision with ample
support and encourage the postdoc participation in international research
conferences and courses. We assist postdoc for an independent global
scientific career through and after the project.
Starting date: December 2021 or on agreement
Duration: 3 years
Salary: according to the University of Bern guidelines
Please send your application including a short letter of interest, curriculum
vitae with description of your professional experience, a list of
publications, a list of 2 contact referees or their references letter as a
single pdf-file by email to:
Prof. Ziad Al Nabhani: firstname.lastname@example.org
Applications will be considered on an on-going basis. A first contact is
usually established through an informal Skype/Zoom interview (~15 minutes).