Postdoc in gene regulatory variability

Copenhagen University

Denmark

December 9, 2021

Description

Department of Biology, Faculty of Science at University of Copenhagen is offering a Postdoc position commencing 1st of March 2022, or as soon as possible thereafter.

Description of the scientific environment

The lab of Robin Andersson focuses on genomics and computational/statistical modeling of transcriptional regulation based on large-scale sequencing data, including experimental data generated from within the lab. We aim to characterize and better understand the architectures and complexities of transcriptional regulation (see e.g. Andersson et al. 2014, Nature) and gain insights into the mechanisms of regulation. We further focus on the fundamental properties of enhancers and promoters (see e.g. Andersson and Sandelin 2020, Nat Rev Genet, 2020). For more information, see https:// anderssonlab.org.

The Andersson lab is based in a highly collaborative environment at the Bioinformatics Centre in the Section for Computational and RNA Biology, which is currently composed of 11 strong research groups. The Department of Biology is located at the Biocenter in central Copenhagen, Denmark.

Project description

The successful candidate is expected to work on a project aiming to investigate the variability of promoter and enhancer activities and how such variability influences responsiveness and robustness of transcriptional output (see https: // www. biorxiv.org/content/10.1101/2021.10.29.466407v1). Focus of the project will be on the association between regulatory variability and gene responsiveness. The project will consider analyses of data both from bulk assays (e.g., CAGE, ATAC-seq, ChIP-seq, STARR-seq) and single cell assays (e.g., snATAC-seq, scRNA-seq).

Principal supervisor is Associate Professor Robin Andersson , Department of Biology, robin@bio.ku.dk.

Formal requirements We are seeking a highly motivated individual with a PhD in Bioinformatics or Computational Biology with extensive experience in transcriptomics and computational analysis of regulatory elements. Practical experiences with eQTL analysis, analysis of CAGE data, and single cell data analysis are considered a plus.

In particular, we are looking for candidates with the following background:

  • A PhD in Bioinformatics, Computational Biology, or in a related quantitative field
  • Strong programming and data analytical skills
  • Documented experience in analyzing high-throughput sequencing data
  • Documented experiences in transcriptomics
  • Documented experiences in computational analysis of regulatory elements
  • A high proficiency in spoken and written English
  • Terms of employment

    Duration is for max 36 months.

    The position is covered by the Memorandum on Job Structure for Academic Staff.

    Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

    Negotiation for salary supplement is possible.

    Application Procedure

    The application, in English , must be submitted electronically by clicking APPLY NOW below.

    Please include

  • Cover letter
  • Curriculum vitae
  • Diplomas (Master and PhD degree or equivalent)
  • Complete publication list
  • The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

    The deadline for applications is December 9th 2021, 23:59 GMT+1.

    After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.

    You can read about the recruitment process at https: // employment.ku.dk/faculty/recruitment-process/ .

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