Do you want to contribute to top quality medical research?
The Department of Laboratory of Medicine, located in Flemingsberg, is one of
the Karolinska Institutet's largest departments with 7 research divisions
including Biomolecular and Cellular Medicine (BCM), where the project will
be carried out.
BCM provides the facilities needed for cell- and molecular biology research
and the possibility to perform research in vivo.
We are seeking a highly motivated person to join the group of Associate
Professor Samir El-Andaloussi as a Postdoctoral Researcher to work on the
development of bioengineered extracellular vesicles (EVs).
Our research efforts in the EL Andaloussi´s lab focus on one of the greatest
challenges facing modern therapeutics; delivery of macromolecules to target
cells in vivo. Despite the unprecedented knowledge of diseases and their
mechanisms due to advances in biomedical sciences; many promising therapeutic
approaches are still clinically unavailable. This is simply because there is
no efficient means of delivering these therapeutics to the right organ with
the right dose. Such therapeutics include proteins for replacement therapy as
well as nucleic acids for gene therapy of diseases including muscular
dystrophies and neurodegenerative disorders.
We develop innovative drug delivery technologies that are able to carry
protein and/or gene therapies to the target tissues safely and efficiently. We
have developed a promising technology based on reprogramming exosomes, which
are vesicles that are naturally used by cells to communicate, to carry
therapeutic proteins and nucleic acids. We engineer exosomes with enhanced
delivery and targeting capacities and screen our wide array of exosome designs
in disease-relevant cellular and animal models. To further enhance the
targeted delivery this project aims to develop targeted functional delivery of
macromolecules for both in vitro and in vivo use.
Most of the research will be conducted utilizing cell lines and animal models.
The first part of the work will involve developing a novel targeting platform
for functional uptake in specific cell populations. Here molecular cloning to
generate novel constructs will be essential and later screening of the novel
constructs in relevant reporter cell lines (the reporter cell lines are
already established in the lab). Successful candidate constructs will later
be developed to target disease relevant targets firstly in vitro and later
in vivo. The work will be highly innovative and require extensive knowledge
regarding molecular biology techniques, cell culture and the process of making
stable cells via lentivirus transduction or transposon transfections.
Qualified to be employed as a postdoctor is one who has obtained a doctorate
or has equivalent scientific competence. Applicants who have not completed a
doctorate at the end of the application period may also apply, provided that
all requirements for a completed degree are met before the (intended) date
of employment. This must be substantiated by the applicant's main supervisor,
director or equivalent.
The applicant should have a solid background in basic biology and/or drug
delivery. The position requires practical lab experience in the following
areas; foremost experience with molecular cloning and extensive knowledge
regarding cell culture work including generation of stable cell clones for
protein expression. Secondly experience with flow cytometric analysis of
protein expression and experience with PCR related techniques. The ideal
candidate would furthermore have experience within the EV or virus field and
previous work within stem cell biology, but this is not required.
In addition, excellent proficiency in both spoken and written English is
important. We are looking for an energetic and passionate person who fits in,
and actively contributes to our team.
What do we offer?
Karolinska Institutet is one of the world's leading medical universities. Our
vision is to pursue the development of knowledge about life and to promote
better health for all. At Karolinska Institutet, we conduct innovative medical
research and provide the largest range of biomedical education in Sweden.
Karolinska Institutet is a state university, which entitles employees to
several benefits such as extended holiday and a generous occupational pension.
Employees also have free access to our modern gym and receive reimbursements
for medical care.
Location and Links
The position is available at the Division of Biomolecular and Cellular
Medicine (BCM) within the Department of Laboratory Medicine at KI South
Read about the Department of Laboratory Medicine
Read about the Division of Biomolecular and Cellular Medicine BCM
Read about the Research Group of Samir EL Andaloussi
An employment application must contain the following documents, preferably in
A complete resumé, including date of the thesis defence, title of the
thesis, previous academic positions, academic title, current position,
academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)
The application is to be submitted through the Varbi recruitment system.
Want to make a difference? Join us and contribute to better health for
|Type of employment
||Temporary position longer than 6 months
|Number of positions
|Last application date
||13.Jun.2021 11:59 PM CET