Postdoc For The Execution Of Opus Scientific Project

Universities and Institutes of Poland

Poland

October 30, 2022

Description

  • Organisation/Company: Institute of Hematology and Transfusion Medicine
  • Research Field: Biological sciences Computer science
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2)
  • Application Deadline: 30/10/2022 12:00 - Europe/Brussels
  • Location: Poland › Warszawa
  • Type Of Contract: Permanent
  • Job Status: Full-time
  • Hours Per Week: 40
  • Offer Starting Date: 01/11/2022
  • Project description:

    AML is the most common form of acute leukaemia in adults: it is responsible for 62% of all leukaemia deaths and it has the fifth worst five-year survival by cancer type, after pancreatic, lung, liver and oesophageal cancers. Unfortunately, it is recognised that there is a population of leukemic stem cells (LSCs) which are more resistant to chemotherapy and can survive the consolidation phase leading to a recurrence of the disease.

    APE1 is an essential enzyme in the DNA base excision repair (BER) pathway, which is responsible for repairing both nuclear and mitochondrial oxidative DNA lesions. APE1 is imported into mitochondria under oxidative stress conditions and the pathway responsible for the entrance of APE1 into the mitochondrial intermembrane space (IMS) is the Mitochondrial Intermembrane Space Assembly (MIA) pathway. Mia40 and ALR represent the central components of the MIA import machinery that uses a redox system to drive cysteine- enriched proteins into the mitochondrial compartment.

    This project proposes to develop an innovative strategy to selectively target therapy-resistant LSCs by inhibiting the MIA pathway. To achieve this goal, we intend to use two parallel strategies to inhibit the MIA pathway: a Mia40 inhibitory peptide-based approach and a in silico drug screening approach for the development of small-molecule modulators.

    This project will extend our understanding of the role of the MIA pathway in cancer cells' behaviour and its role in the metabolic reprogramming of AML therapy-resistant cells, setting the basis for the development of alternative or adjuvant approaches for cancer treatment.

    Scope of work:

    The successful candidate will be dealing with all of the screening and molecular modeling tasks including/beside direct experimental testing. Special emphasis will be placed on data molecular modeling skills, preparation and wrangling techniques (data acquisition and filtering). She/he will make use of computational techniques such as molecular docking, molecular mechanics and dynamics simulations. Finally she/he will be training and testing ML/DL models.

    Required professional qualifications:

    For this position a senior post-doc with previous experience acquired during the PhD and/or post-doc in bioinformatics and structural studies is required. Additional required skills:

    1. Programming skills (Python and/or R)

    2. Knowledge of basic chemistry and/or computational chemistry.

    3. Cheminformatics skills (rdkit, openbabel, knime, etc) will be a bonus.

    4. Basic knowledge of ML/DL frameworks (Tensorflow and/or PyTorch) will be a bonus.

    The anticipated average fellowship: 10 000 PLN/month (brutto/brutto) for 18 months with possible extension.

    Deadline for submitting offers: October 30, 2022, 23:59

    Applications should be sent by e-mail to the project manager: dr hab.

    Carlo Vascotto carlo.vascotto@uniud.it , and to dr hab. Paweł Siedlecki pawel@ibb.waw.pl

    NCN call for proposals type: OPUS – ND

    Required documents:

  • CV
  • Motivation letter with justification of the matching to the project
  • Copy of PhD degree diploma
  • Letter of support from the PhD thesis supervisor
  • Additional comments The application documents should include the following statement: „I hereby give consent to process my personal data included in my offer,

    for the purposes of the recruitment procedure, and to disclose my name and surname in the "recruitment results" section of the IHT website, by the Institute of Hematology and Transfusion Medicine, address: I. Gandhi 14 Str, Warsaw, Poland ; REGON 000849327, NIP 777-00-02-062 (further referred to as the Institute). I acknowledge that the Institute hereby becomes the administrator of my data. I have been acquainted with all the consequences resulting thereof, in particular with the following facts:

    1. For more details with regard to processing my personal data, I can

    contact the Data Protection Officer: iod@ihit.waw.pl

    2. My personal data are processed for the purposes of the recruitment

    procedure.

    3. Members of the relevant recruitment committees are recipients of my

    personal data.

    4. My personal data shall not be transferred to any Third Party. 5. My personal data will be processed for the period of 28 days upon the

    date when the recruitment procedure is concluded. Following this period, they will be irretrievably and effectively destroyed, so that they can no longer be accessed or reconstructed by any means.

    At the same time, I acknowledge that I have the right to request from the

    Institute access to my personal data and the right to amend them or withdraw my consent to process them. I also declare that I have been informed about my right to file complaint to the President of the Office for Personal Data Protection, in the case when the Institute breaches the principles of processing my personal data, stipulated in the Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC”.

    Contact Information
  • Organisation/Company: Institute of Hematology and Transfusion Medicine
  • Organisation Type: Other
  • Website: https:// www. ihit.waw.pl
  • Country: Poland
  • City: Warsaw
  • Postal Code: 02-766
  • Street: Indity Gandhi 14
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