Postdoc (f/m/d) – Cell biology of ubiquitin ligase complexes –
Job Code: 26-21
Job Offer from January 01, 2022
The Max Planck Institutes for Biophysical Chemistry and Experimental Medicine
in Göttingen are internationally leading research institutes of exceptional
scientific breadth, which will merge in 2022 to become the largest institute
of the Max Planck Society. The new institute will comprise more than 40
research groups and employ around 1,000 people from over 50 nations.
The research group Ubiquitin Signaling Specificity (Dr. Sonja Lorenz)
invites applications for a position as
– Cell biology of ubiquitin ligase complexes –
Our lab aims to understand how ubiquitin − a single, small protein −
achieves specificity in regulating virtually all aspects of eukaryotic cell
biology. A major key lies in the action of ubiquitin ligases, the most
diversified class of enzymes of the ubiquitin system. The immense potential of
ubiquitin ligases as therapeutic targets is illustrated by the clinical
efficacy of thalidomide and derivatives in the treatment of hematologic
malignancies. However, progress towards rationally manipulating these enzymes
has been impeded largely by our insufficient understanding of their
integration into macromolecular complexes and the associated structural and
functional consequences. We aim to identify and characterize macromolecular
complexes of ubiquitin ligases to decipher the molecular basis of their
specificities in substrate recognition and ubiquitin chain formation. To
this end, we combine chemical-biological, biochemical, cell biological, and
structural approaches with a particular focus on cryo-electron microscopy.
We have a fully-funded postdoc position available for a talented individual
to uncover cellular ubiquitin ligase assemblies implicated in
You have a PhD or equivalent degree in a relevant subject area, such as
cell and molecular biology, biochemistry or biomedicine.
You have a proven track record in molecular cloning and cell biology,
specifically in one or more of the following techniques:
Crispr/Cas9-mediated gene editing, RNA interference, cell fractionation,
co-IP, immunofluorescence, and live-cell imaging.
Additional experience in neuronal cell culture and/or proteomics will be
You are curiosity-driven and eager to interact with biochemists and
You are passionate about science and keen to establish creative new
approaches to tackle challenging protein complexes.
You are self-motivated and independent, and enjoy being part of an
international, multidisciplinary team.
We are an independent research group at the Max Planck Institute for
Biophysical Chemistry, one of Germany's premier research campuses with
leading-edge infracture in all fields of structural and cell biology. We are a
highly international and interdisciplinary team, funded by the Max Planck
Society, the German Research foundation, and the EMBO YIP. The historic city
of Goettingen, located in the center of Germany, offers great outdoor and
cultural opportunities, a bustling student scene, and an impressive scientific
The position should be filled as soon as possible, but the exact start date is
flexible. The position is initially for 2 years with the possibility of
extension. Payment and benefits are based on the TVöD guidelines.
The Max Planck Society is committed to increasing the number of individuals
with disabilities in its workforce and therefore encourages applications from
such qualified individuals. The Max Planck Society strives for gender and
diversity equality. We welcome applications from all backgrounds.
Please submit your application including cover letter (explaining background
and motivation), CV, transcripts, and publication record by e-mail as a
single PDF file to the email address below. Review of applications will begin
immediate. Informal inquiries are also welcome.
Max Planck Institute for Biophysical Chemistry
Research Group „ Ubiquitin Signaling Specificity “
Am Fassberg 11