1 Nov 2023
Job InformationOrganisation/Company
CNRS
Department
Institut des matériaux de Nantes Jean Rouxel
Research Field
Chemistry » Physical chemistry
Physics » Chemical physics
Physics » Biophysics
Researcher Profile
First Stage Researcher (R1)
Country
France
Application Deadline
21 Nov 2023 - 23:59 (UTC)
Type of Contract
Temporary
Job Status
Full-time
Hours Per Week
35
Offer Starting Date
1 Jan 2024
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?
No
Offer DescriptionInjectable polymers sensitive to temperature changes are particularly well adapted for applications in tissue engineering due to their injectability at room temperature, allowing a mini-invasive treatment and in situ sol-gel transition at physiological temperature, enabling a rapid gel formation after injection. Although hydrogels based on natural or synthetic polymers already exist, injectable, thermoresponsive and biologically active hydrogels are still highly required. In this context, in the frame of national ANR grant “Smarties” (ANR-22-CE52-0005-01), the main objective is to develop a new thermosensitive and injectable hydrogel based on marine bacterial exopolysaccharide (EPS) endowed with biological properties able to repair an osteochondral defect. In this context, the candidate will work to covalently graft a termoresponsive polymer onto the EPS chains, before to fully characterize the gelling properties of the obtained hydrogels by determining their injectability, mechanical properties and relaxation times. The structure-mechanical properties relationship of hydrogels will be also investigated by microscopies (SEM, AFM).
The candidate should : - functionalize EPS with a thermo-sensistive polymer by covalent grafting - characterize the chemical grafting - elaborate hydrogels from the functionalized EPS - characterize the structural and mechanical properties of hydrogels (SEM, rheology, AFM)
The candidate will join the "Physique des Matériaux et des Nanostructures (PMN)" team at the Institute of materials of Nantes Jean Rouxel (https: // www. cnrs-imn.fr/).
RequirementsResearch Field
Chemistry
Education Level
PhD or equivalent
Research Field
Physics
Education Level
PhD or equivalent
Research Field
Physics
Education Level
PhD or equivalent
Languages
FRENCH
Level
Basic
Research Field
Chemistry » Physical chemistry
Years of Research Experience
None
Research Field
Physics » Chemical physics
Years of Research Experience
None
Research Field
Physics » Biophysics
Years of Research Experience
None
Eligibility criteria
The candidate must have a strong background in the synthesis related to polysaccharides, as well as in the material characterization, especially using SEM, rheology and AFM techniques.
Website for additional job details
https: // emploi.cnrs.fr/Offres/CDD/UMR6502-STECUE-001/Default.aspx
Work Location(s)Number of offers available
1
Company/Institute
Institut des matériaux de Nantes Jean Rouxel
Country
France
City
NANTES
Website
https: // emploi.cnrs.fr/Candidat/Offre/UMR6502-STECUE-001/Candidater.aspx
ContactCity
NANTES
Website
https:// www. cnrs-imn.fr
STATUS: EXPIRED