Post Doctoral

Universities and Institutes of France

France

August 31, 2022

Description

  • Organisation/Company: INSERM DR Grand Ouest
  • Research Field: Biological sciences
  • Researcher Profile: Recognised Researcher (R2)
  • Application Deadline: 31/08/2022 23:00 - Europe/Athens
  • Location: France › RENNES
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 38.5
  • Offer Starting Date: 01/10/2022
  • B-cell acute lymphoblastic leukemia (B-ALL), malignant counterpart of BM differentiating B cells, represents the most common cancer in childhood and, although less frequent, corresponds to a similar number of cases in adults. New combinations of chemotherapeutic agents, have dramatically improved disease outcome in children, but the overall survival of adults at diagnosis and after relapse remains low. Resistance to treatment in B-ALL partially relies on protective cues provided by BM stromal cells.

    Using state-of-the-art technologies, our research focus on deciphering the interactions between leukemic cells and the different constituents of the bone marrow microenvironment. Our team has a special interest on the cell-non- autonomous cues influencing leukemogenesis and B-ALL progression. Genetic mouse models available in the lab and strong relationships with the clinical hematology department allow us to address both fundamental and translational questions with the goal of identifying new potential therapeutic targets. The post-doc candidate will have in charge the investigation of elements affecting niche homeostasis and having a potential influence on B-ALL development using transgenic mouse models and patient-derived xenografts.

    Rennes is located in Brittany in the west of France. In addition to its Celtic heritage, Rennes is at 1h from St Malo on the Channel, 1b5 from the Mont St Michel, 1b0 from Vannes on the Atlantic Ocean and 1b0 from Paris.

    Located in the medical campus of Rennes University, our group belongs to the academic INSERM U1236 research team. Our lab has a major expertise in the pathophysiology and microenvironment of B-cell lymphoproliferation with a special interest in the crosstalk between tumor cells and their supportive niches. The team works together with the clinicians of the service of clinical hematology in Rennes hospital and has a facilitated access to patient samples.

    As a post-doc, you will have a full access to several facilities available in the lab and within the BIOSIT core facilities (https: // biosit.univ- rennes1.fr) including confocal microscopes, flow cytometry/cell sorter facility, single cell qPCR and scRNAseq plateform…

    Main Activities
  • Bench work
  • Data analysis
  • Master and PhD student supervision
  • Manuscript writing
  • Contract

    Type : Post Doctoral

    Duration : 2-year contract with a possible 1-year reconduction

    Salary : 30'500€ to 35'000€/year before tax, depending on experience

    Envisaged Start Date : October 2022

    Selection process Application

    Applicants must send a CV and a cover letter to:

    Contact for further information (name, telephone/mail):

    Dr Stéphane MANCINI

    stephane.mancini@univ-rennes1.fr

    and

    Dr Tony MARCHAND

    tony.marchand@univ-rennes1.fr

    Web site for additional job details

    https: // mobidic.univ-rennes1.fr/project-4-bone-marrow-supportive-niches-b-all

    Required Research Experiences
  • RESEARCH FIELD
  • Biological sciences

  • YEARS OF RESEARCH EXPERIENCE
  • 1 - 4

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: PhD or equivalent

  • REQUIRED LANGUAGES
  • ENGLISH: Good

    FRENCH: Basic

    Skills/Qualifications

    We are looking for a highly dynamic, flexible and proactive post doc. Strong experience in mouse models, flow cytometry, confocal microscopy and cell culture. An expertise in hematopoiesis, tumor microenvironment and bioinformatics would be welcome.

    Contact Information
  • Organisation/Company: INSERM DR Grand Ouest
  • Organisation Type: Public Research Institution
  • Website: https: // grand-ouest.inserm.fr/
  • Country: France
  • City: NANTES
  • Postal Code: 44200
  • Street: 24 Boulevard Vincent Gâche
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