Description
Organisation/Company: INSERM DR Grand Ouest
Research Field: Biological sciences
Researcher Profile: Recognised Researcher (R2)
Application Deadline: 31/08/2022 23:00 - Europe/Athens
Location: France › RENNES
Type Of Contract: Temporary
Job Status: Full-time
Hours Per Week: 38.5
Offer Starting Date: 01/10/2022
B-cell acute lymphoblastic leukemia (B-ALL), malignant counterpart of BM
differentiating B cells, represents the most common cancer in childhood and,
although less frequent, corresponds to a similar number of cases in adults.
New combinations of chemotherapeutic agents, have dramatically improved
disease outcome in children, but the overall survival of adults at diagnosis
and after relapse remains low. Resistance to treatment in B-ALL partially
relies on protective cues provided by BM stromal cells.
Using state-of-the-art technologies, our research focus on deciphering the
interactions between leukemic cells and the different constituents of the bone
marrow microenvironment. Our team has a special interest on the cell-non-
autonomous cues influencing leukemogenesis and B-ALL progression. Genetic
mouse models available in the lab and strong relationships with the clinical
hematology department allow us to address both fundamental and translational
questions with the goal of identifying new potential therapeutic targets. The
post-doc candidate will have in charge the investigation of elements affecting
niche homeostasis and having a potential influence on B-ALL development using
transgenic mouse models and patient-derived xenografts.
Rennes is located in Brittany in the west of France. In addition to its Celtic
heritage, Rennes is at 1h from St Malo on the Channel, 1b5 from the Mont St
Michel, 1b0 from Vannes on the Atlantic Ocean and 1b0 from Paris.
Located in the medical campus of Rennes University, our group belongs to the
academic INSERM U1236 research team. Our lab has a major expertise in the
pathophysiology and microenvironment of B-cell lymphoproliferation with a
special interest in the crosstalk between tumor cells and their supportive
niches. The team works together with the clinicians of the service of clinical
hematology in Rennes hospital and has a facilitated access to patient samples.
As a post-doc, you will have a full access to several facilities available in
the lab and within the BIOSIT core facilities (https: // biosit.univ-
rennes1.fr) including confocal microscopes, flow cytometry/cell sorter
facility, single cell qPCR and scRNAseq plateform…
Main Activities
Bench work
Data analysis
Master and PhD student supervision
Manuscript writing
Contract
Type : Post Doctoral
Duration : 2-year contract with a possible 1-year reconduction
Salary : 30'500€ to 35'000€/year before tax, depending on experience
Envisaged Start Date : October 2022
Selection process
Application
Applicants must send a CV and a cover letter to:
Contact for further information (name, telephone/mail):
Dr Stéphane MANCINI
stephane.mancini@univ-rennes1.fr
and
Dr Tony MARCHAND
tony.marchand@univ-rennes1.fr
Web site for additional job details
https: // mobidic.univ-rennes1.fr/project-4-bone-marrow-supportive-niches-b-all
Required Research Experiences
RESEARCH FIELD
Biological sciences
YEARS OF RESEARCH EXPERIENCE
1 - 4
Offer Requirements
REQUIRED EDUCATION LEVEL
Biological sciences: PhD or equivalent
REQUIRED LANGUAGES
ENGLISH: Good
FRENCH: Basic
Skills/Qualifications
We are looking for a highly dynamic, flexible and proactive post doc. Strong
experience in mouse models, flow cytometry, confocal microscopy and cell
culture. An expertise in hematopoiesis, tumor microenvironment and
bioinformatics would be welcome.
Contact Information
Organisation/Company: INSERM DR Grand Ouest
Organisation Type: Public Research Institution
Website: https: // grand-ouest.inserm.fr/
Country: France
City: NANTES
Postal Code: 44200
Street: 24 Boulevard Vincent Gâche
