Passionate about fighting bacteria and antibiotic discovery?
A post-doctoral research position investigating the molecular biology and
potential of novel siderophore conjugates (ERC-COG research project
ANTBIOCLICKS), is now open in the Hartkoorn Lab located at the Institut
Pasteur of Lille. The Hartkoorn lab's primary focus is on innovation in
antibiotic drug discovery and development.
The frightening increase in antibiotic drug resistance is threatening global
healthcare as we know it. To this extent, the World Health Organisation that
has classes M. tuberculosis and a number of Gram-negative infections as the
highest priority for novel R&D strategies. A major obstacle to drug discovery
programs is to design inhibitors that can efficiently enter into bacteria. One
such strategy is by coupling antibiotic molecules to siderophores that are
taken up by the bacteria for iron acquisition. In this project, ANTIBIOCLICKS,
new bioinspired siderophore conjugates are being developed for such a stealth
delivery system targeting M. tuberculosis, A. baumannii, E. coli, P.
aeruginosa and K. pneumonia. The particular focus for this research project
will be to define the potential of new bioinspired siderophore conjugates for
antibiotic delivery into A. baumannii and P. aeruginosa, and to clearly define
the mechanisms of sideromycin uptake and intracellular decoupling.
Applicants should hold a PhD in a relevant biology field (molecular biology,
pharmacology, pharmacy, microbiology etc). Applicants are expected to have a
strong background in bacterial research including specific experience with A.
baumannii and P. aeruginosa. Candidates need be competent in bacterial genetic
engineering, understand of how antibiotics function, and have experience with
imaging techniques for bacteria. Previous experience in siderophores research
is a bonus. The candidate will need to work as part of a multidisciplinary
team and communicate in English. Written English and manuscript writing must
As soon as possible
Interested applicant should contact Ruben Hartkoorn
(firstname.lastname@example.org), with the subject: Postdoc Application
AntiBioClicksBio2022, and provide a CV and a cover letter (English).
Organisation/Company: Institut Pasteur de Lille
Department: The Center for Infection and Immunity of Lille
rationally optimizing a combination therapy for a novel class of anti-
The Hartkoorn lab is located at the Institut Pasteur
of Lille and is focused on innovation in antibiotic drug discovery and
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