Post-Doctoral Researcher (Postdoc) On An Erc-Cog Research Program Investigating The Molecular...

Universities and Institutes of France

France

September 30, 2022

Description

  • Organisation/Company: Institut Pasteur de Lille
  • Research Field: Biological sciences › Other
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2)
  • Application Deadline: 30/09/2022 23:00 - Europe/Brussels
  • Location: France › Lille
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 36
  • Offer Starting Date: 01/11/2022
  • Eu Research Framework Programme: H2020 / ERC
  • Reference Number: 864832
  • Passionate about fighting bacteria and antibiotic discovery?

    A post-doctoral research position investigating the molecular biology and potential of novel siderophore conjugates (ERC-COG research project ANTBIOCLICKS), is now open in the Hartkoorn Lab located at the Institut Pasteur of Lille. The Hartkoorn lab's primary focus is on innovation in antibiotic drug discovery and development.

    The frightening increase in antibiotic drug resistance is threatening global healthcare as we know it. To this extent, the World Health Organisation that has classes M. tuberculosis and a number of Gram-negative infections as the highest priority for novel R&D strategies. A major obstacle to drug discovery programs is to design inhibitors that can efficiently enter into bacteria. One such strategy is by coupling antibiotic molecules to siderophores that are taken up by the bacteria for iron acquisition. In this project, ANTIBIOCLICKS, new bioinspired siderophore conjugates are being developed for such a stealth delivery system targeting M. tuberculosis, A. baumannii, E. coli, P. aeruginosa and K. pneumonia. The particular focus for this research project will be to define the potential of new bioinspired siderophore conjugates for antibiotic delivery into A. baumannii and P. aeruginosa, and to clearly define the mechanisms of sideromycin uptake and intracellular decoupling.

    Applicants should hold a PhD in a relevant biology field (molecular biology, pharmacology, pharmacy, microbiology etc). Applicants are expected to have a strong background in bacterial research including specific experience with A. baumannii and P. aeruginosa. Candidates need be competent in bacterial genetic engineering, understand of how antibiotics function, and have experience with imaging techniques for bacteria. Previous experience in siderophores research is a bonus. The candidate will need to work as part of a multidisciplinary team and communicate in English. Written English and manuscript writing must be excellent.

    Starting date

    As soon as possible

    Contact

    Interested applicant should contact Ruben Hartkoorn (ruben.hartkoorn@inserm.fr), with the subject: Postdoc Application AntiBioClicksBio2022, and provide a CV and a cover letter (English).

    Contact Information
  • Organisation/Company: Institut Pasteur de Lille
  • Department: The Center for Infection and Immunity of Lille
  • Organisation Type: Higher Education Institute
  • Website: https: // www. ciil.fr/
  • Country: France
  • City: Lille
  • Street: 1, rue du professeur Calmette
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