Post-Doctoral Researcher Position (Postdoc): Developing A New Anti-Tuberculosis Candidate Into A...

Universities and Institutes of France

France

September 30, 2022

Description

  • Organisation/Company: Institut Pasteur de Lille
  • Research Field: Biological sciences › Other
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2)
  • Application Deadline: 30/09/2022 21:00 - Europe/Brussels
  • Location: France › Lille
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 36
  • Offer Starting Date: 01/01/2023
  • Reference Number: Application ACDC2022
  • Passionate about fighting tuberculosis and antibiotic discovery?

    A post-doctoral research position is now open in the Hartkoorn Lab aimed at rationally optimizing a combination therapy for a novel class of anti- tuberculosis molecules. The Hartkoorn lab is located at the Institut Pasteur of Lille and is focused on innovation in antibiotic drug discovery and development.

    Current multi-drug combination therapy for the treatment of tuberculosis remains lengthy and is threatened by substantial prevalence of multidrug and extensively drug resistant tuberculosis. Recent advances in tuberculosis drug development have defined novel promising drug combination (BPaL, combination of Bedaquiline, Pretomanid and Linezolid), though unavoidable resistance to the BPaL antibiotics is already emerging. It therefore remains important that novel anti-tuberculosis molecules are discovered and developed into next generation combinations. In this context, a novel class of potent anti- tuberculosis molecules (named TriSLa) has been developed that act on a new protein target of the bacterial electron transport chain. This work was done in collaboration with the team of medicinal chemists (Pr Nicolas Willand and Dr Baptiste Villemagne) from the Deprez Lab. In light of these promising data, the aim of this project is to rationally define the therapeutic potential of these TriSla molecules and optimise they efficacy in a combination therapy for the treatment of Mtb infections.

    Applicants should hold a PhD in a relevant biology field (molecular biology, pharmacology, pharmacy, microbiology etc). Applicants must have experience working with M. tuberculosis, preferably in the context of drug discovery. Experience in metabolomics, protein purification and biochemistry is a major bonus. The candidate will need to work as part of a multidisciplinary team and communicate effectively in English or French with excellent written English.

    Starting date

    As soon as possible

    Contact

    Interested applicant should contact Ruben Hartkoorn (ruben.hartkoorn@inserm.fr), with the subject: Postdoc Application ACDC2022, and provide a CV and a cover letter (English).

    Contact Information
  • Organisation/Company: Institut Pasteur de Lille
  • Department: The Center for Infection and Immunity of Lille
  • Organisation Type: Higher Education Institute
  • Website: https: // www. ciil.fr/
  • Country: France
  • City: Lille
  • Street: 1, rue du professeur Calmette
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