Post-Doctoral Research Position "Electrochemistry Of Human Cells"

Universities and Institutes of France

France

November 12, 2021

Description

  • Organisation/Company: Université Paul Sabatier, Toulouse
  • Research Field: Biological sciences › Biological engineering Biological sciences › Biology Chemistry
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2) Established Researcher (R3) Leading Researcher (R4)
  • Application Deadline: 12/11/2021 00:00 - Europe/Athens
  • Location: France › Toulouse
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • For the last two decades, the electrochemistry of bacteria has taken a considerable importance in the design of new biotechnological processes. The number of scientific papers devoted to this topic is continuously increasing, revealing more and more sophisticated mechanisms of cell/electrode electron transfers 1-3. Until now, most of the works have been carried out with prokaryotic cells. However, several research groups have started to demonstrate the existence of electron transfers between electrodes and eukaryotic cells 4.

    The objective of the TECH project, which is the framework for the postdoc topic, is to extend the field of cellular electrochemistry to human cells. A thesis, defended in May 2021 as part of the project, has yielded promising results on the ability of some human and animal cells to perform extracellular electron transfers. The objective of the post-doctoral work is to extend these studies to progenitor cells from human adipose tissue.

    The aim will be to define the experimental conditions allowing to enhance or inhibit the electron transfers and to characterize these processes by combining electrochemical and biological analyses. The post-doctoral fellow will benefit from the experience of the LGC and I2MC teams, one expert in the design of electrode/bacteria interfaces and the other in the culture and characterization of human progenitor cells. In the long term, the research may have some impact on the understanding of metabolic dysfunctions such as overweight and obesity.

    References

  • Electroactive biofilms: Current status and future research needs, Borole et al., 2011, Energy and Environmental Science 4, 4813-4834; DOI 10.1039/c1ee02511b
  • The ins and outs of microorganism-electrode electron transfer reactions, Kumar et al., 2017, Nature Reviews Chemistry 1, 0024; DOI 10.1038/s41570-017-0024
  • Electroactive microorganisms in bioelectrochemical systems, Logan et al., 2019, Nature Reviews Microbiology 17, 307-319; DOI 10.1038/s41579-019-0173-x
  • Extracellular electron transfer in yeast-based biofuel cells: A review, Hubenova et al., 2015, Bioelectrochemistry 106, 177-185; DOI 10.1016/j.bioelechem.2015.0001
  • Offer Requirements Specific Requirements

    Given the multidisciplinary nature of the subject, it is not necessary for the candidate to master all the disciplinary fields addressed. Ideally, the candidate will have a background in biotechnology and some experience in animal or human cell culture.

    Competence in cellular redox systems (mitochondria, cell membrane, redox enzymes...) would be an additional asset.

    The subject is scientifically ambitious; the candidate must be motivated by a challenging research both on the conceptual level and on the care to be taken in the experimental achievements. He/she will have to be able to continuously confront his/her results with the researchers involved in the project in order to take full advantage of his/her multidisciplinary scientific environment.

    Contact Information
  • Organisation/Company: Université Paul Sabatier, Toulouse
  • Organisation Type: Public Research Institution
  • Country: France