For the last two decades, the electrochemistry of bacteria has taken a
considerable importance in the design of new biotechnological processes. The
number of scientific papers devoted to this topic is continuously increasing,
revealing more and more sophisticated mechanisms of cell/electrode electron
transfers 1-3. Until now, most of the works have been carried out with
prokaryotic cells. However, several research groups have started to
demonstrate the existence of electron transfers between electrodes and
eukaryotic cells 4.
The objective of the TECH project, which is the framework for the postdoc
topic, is to extend the field of cellular electrochemistry to human cells. A
thesis, defended in May 2021 as part of the project, has yielded promising
results on the ability of some human and animal cells to perform extracellular
electron transfers. The objective of the post-doctoral work is to extend these
studies to progenitor cells from human adipose tissue.
The aim will be to define the experimental conditions allowing to enhance or
inhibit the electron transfers and to characterize these processes by
combining electrochemical and biological analyses. The post-doctoral fellow
will benefit from the experience of the LGC and I2MC teams, one expert in the
design of electrode/bacteria interfaces and the other in the culture and
characterization of human progenitor cells. In the long term, the research may
have some impact on the understanding of metabolic dysfunctions such as
overweight and obesity.
Electroactive biofilms: Current status and future research needs, Borole et al., 2011, Energy and Environmental Science 4, 4813-4834; DOI 10.1039/c1ee02511b
The ins and outs of microorganism-electrode electron transfer reactions, Kumar et al., 2017, Nature Reviews Chemistry 1, 0024; DOI 10.1038/s41570-017-0024
Electroactive microorganisms in bioelectrochemical systems, Logan et al., 2019, Nature Reviews Microbiology 17, 307-319; DOI 10.1038/s41579-019-0173-x
Extracellular electron transfer in yeast-based biofuel cells: A review, Hubenova et al., 2015, Bioelectrochemistry 106, 177-185; DOI 10.1016/j.bioelechem.2015.0001
Offer RequirementsSpecific Requirements
Given the multidisciplinary nature of the subject, it is not necessary for the
candidate to master all the disciplinary fields addressed. Ideally, the
candidate will have a background in biotechnology and some experience in
animal or human cell culture.
Competence in cellular redox systems (mitochondria, cell membrane, redox
enzymes...) would be an additional asset.
The subject is scientifically ambitious; the candidate must be motivated by a
challenging research both on the conceptual level and on the care to be taken
in the experimental achievements. He/she will have to be able to continuously
confront his/her results with the researchers involved in the project in order
to take full advantage of his/her multidisciplinary scientific environment.
Organisation/Company: Université Paul Sabatier, Toulouse